Global burden. of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;396(10258):1204–22.

Article  Google Scholar 

http://www.who.int/news-room/fact-sheets/detail/asthma.

Fainardi V, Esposito S, Chetta A, Pisi G. Asthma phenotypes and endotypes in childhood. Minerva Med. 2022;113(1):94–105. https://doi.org/10.23736/S0026-4806.21.07332-8.

Article  PubMed  Google Scholar 

Scherzer R, Grayson MH. Heterogeneity and the origins of asthma. Annals allergy asthma immunology: official publication Am Coll Allergy Asthma Immunol. 2018;121(4):400–5. https://doi.org/10.1016/j.anai.2018.06.009.

Article  Google Scholar 

Fuhlbrigge AL, Sharma S. Unraveling the heterogeneity of asthma: decoding subtypes of asthma. J Allergy Clin Immunol. 2025;156(1):41–50.

Porpodis K, Tsiouprou I, Apostolopoulos A, Ntontsi P, Fouka E, Papakosta D, Domvri K. Eosinophilic asthma, phenotypes-endotypes and current biomarkers of choice. J Pers Med. 2022;12(7):1093.

Article  PubMed  PubMed Central  Google Scholar 

Reza MI, Ambhore NS. Inflammation in Asthma: Mechanistic Insights and the Role of Biologics in Therapeutic Frontiers. Biomedicines. 2025;13(6):1342.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo W, Hu J, Xu W, Dong J. Distinct spatial and temporal roles for Th1, Th2, and Th17 cells in asthma. Front Immunol. 2022;13:974066. https://doi.org/10.3389/fimmu.2022.974066.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Olsthoorn SE, van Krimpen A, Hendriks RW, Stadhouders R. Chronic inflammation in asthma: looking beyond the Th2 cell. Immunol Rev. 2025;330(1):e70010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Y, Abel PW, Casale TB, Tu Y. TH17 cells and corticosteroid insensitivity in severe asthma. J Allergy Clin Immunol. 2022;149(2):467–79. https://doi.org/10.1016/j.jaci.2021.12.769.

Article  CAS  PubMed  Google Scholar 

Sun B, Shen K, Zhao R, Li Y, Xiang M, Lin J. Precision medicine for severe asthma–Biological targeted therapy. Int Immunopharmacol. 2024;134:112189.

Article  CAS  PubMed  Google Scholar 

Faria N, Costa MI, Fernandes AL, Fernandes A, Fernandes B, Machado DC, Machado F, Simão L, Ribeiro L, Ferreira L, Boaventura R, Lima R, Ferreira J. Biologic Therapies for Severe Asthma: Current Insights and Future Directions. J Clin Med. 2025;14(9):3153. https://doi.org/10.3390/jcm14093153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamada Y, Thomas D, McDonald VM, Fricker M, Heaney LG, Gibson PG. Clinical remission in severe asthma treated with biologics and macrolides: Definition, prevalence, associated factors, and future perspectives. Allergology Int. 2026;75(1):15–25.

Article  CAS  Google Scholar 

Sinyor B, Perez LC. Pathophysiology of asthma. StatPearls. StatPearls Publishing; 2023.

Hammad H, Lambrecht BN. The basic immunology of asthma. Cell. 2021;184(6):1469–85.

Article  CAS  PubMed  Google Scholar 

Ricciardolo FLM, Sprio AE, Baroso A, Gallo F, Riccardi E, Bertolini F, Carriero V, Arrigo E, Ciprandi G. Characterization of T2-Low and T2-High Asthma Phenotypes in Real-Life. Biomedicines. 2021;9(11):1684. https://doi.org/10.3390/biomedicines9111684.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yamasaki A, Okazaki R, Harada T. Neutrophils and Asthma. Diagnostics (Basel Switzerland). 2022;12(5):1175. https://doi.org/10.3390/diagnostics12051175.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-α and IFN-γ promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019;316(1):L71–81. https://doi.org/10.1152/ajplung.00547.2017.

Article  CAS  PubMed  Google Scholar 

Ray A, Kolls JK. Neutrophilic Inflammation in Asthma and Association with Disease Severity. Trends Immunol. 2017;38(12):942–54. https://doi.org/10.1016/j.it.2017.07.003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ford ML, Reza MI, Ruwanpathirana A, Sathish V, Britt RD Jr. Integrative Roles of Pro-Inflammatory Cytokines on Airway Smooth Muscle Structure and Function in Asthma. Immunol Rev. 2025;330(1):e70007. https://doi.org/10.1111/imr.70007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Volder J, Vereecke L, Joos G, Maes T. Targeting neutrophils in asthma: A therapeutic opportunity? Biochem Pharmacol. 2020;182:114292.

Article  PubMed  Google Scholar 

Fahy JV, Jackson ND, Sajuthi SP, Pruesse E, Moore CM, Everman JL, Rios C, Tang M, Gauthier M, Wenzel SE, Bleecker ER. Asthma severity and corticosteroid response depend on variable type 1 and type 2 inflammation in the airway. medRxiv. 2023-10.

Maspero J, Adir Y, Al-Ahmad M, Celis-Preciado CA, Colodenco FD, Giavina-Bianchi P, Lababidi H, Ledanois O, Mahoub B, Perng DW, Vazquez JC, Yorgancioglu A. Type 2 inflammation in asthma and other airway diseases. ERJ open Res. 2022;8(3):00576–2021. https://doi.org/10.1183/23120541.00576-2021.

Article  PubMed  PubMed Central  Google Scholar 

Coverstone AM, Seibold MA, Peters MC. Diagnosis and management of T2-high asthma. J Allergy Clin Immunology: Pract. 2020;8(2):442–50.

Article  Google Scholar 

Busse WW, Kraft M, Rabe KF, Deniz Y, Rowe PJ, Ruddy M, Castro M. Understanding the key issues in the treatment of uncontrolled persistent asthma with type 2 inflammation. Eur Respir J. 2021;58(2).

Gauvreau GM, Bergeron C, Boulet LP, Cockcroft DW, Côté A, Davis BE, Leigh R, Myers I, O’Byrne PM, Sehmi R. Sounding the alarmins-The role of alarmin cytokines in asthma. Allergy. 2023;78(2):402–17. https://doi.org/10.1111/all.15609.

Article  PubMed  Google Scholar 

Iwata A, Toda Y, Furuya H, Nakajima H. Group 2 innate lymphoid cells in human asthma. Allergology Int. 2023;72(2):194–200.

Article  CAS  Google Scholar 

Novosad J, Krčmová I, Souček O, Drahošová M, Sedlák V, Kulířová M, Králíčková P. Subsets of Eosinophils in Asthma, a Challenge for Precise Treatment. Int J Mol Sci. 2023;24(6):5716. https://doi.org/10.3390/ijms24065716.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuruvilla ME, Lee FE, Lee GB. Understanding Asthma Phenotypes, Endotypes, and Mechanisms of Disease. Clin Rev Allergy Immunol. 2019;56(2):219–33. https://doi.org/10.1007/s12016-018-8712-1.

Article  PubMed  PubMed Central  Google Scholar 

Popović-Grle S, Štajduhar A, Lampalo M, Rnjak D. Biomarkers in Different Asthma Phenotypes. Genes. 2021;12(6):801. https://doi.org/10.3390/genes12060801.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guida G, Bagnasco D, Carriero V, Bertolini F, Ricciardolo FLM, Nicola S, Heffler E. Critical evaluation of asthma biomarkers in clinical practice. Front Med. 2022;9:969243.

Article  Google Scholar 

Wan XC, Woodruff PG. Biomarkers in Severe Asthma. Immunol Allergy Clin North Am. 2016;36(3):547–57. https://doi.org/10.1016/j.iac.2016.03.004.

Article  PubMed  PubMed Central  Google Scholar 

Sim S, Choi Y, Park HS. Update on Inflammatory Biomarkers for Defining Asthma Phenotype. Allergy Asthma Immunol Res. 2024;16(5):462–72. https://doi.org/10.4168/aair.2024.16.5.462.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tiotiu A. Biomarkers in asthma: state of the art. Asthma Res Pract. 2018;4(1):10.

Article  PubMed