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CD8 T Cells You Should Know about in Autoimmunity: Current Paradigms of T Cell Pathogenesis in Autoimmune Disease
CD8 T Cells You Should Know about in Autoimmunity: Current Paradigms of T Cell Pathogenesis in Autoimmune Disease
CD8 T cells comprise a large portion of cells in inflamed tissues in many autoimmune diseases, yet their roles in autoimmu...
Strategies for Tapering the Dosage of Biologics Targeting Type 2 Inflammation: A Systematic Review
Strategies for Tapering the Dosage of Biologics Targeting Type 2 Inflammation: A Systematic Review
This review evaluates current evidence on tapering strategies for anti–type 2 biologics in chronic inflammatory dise...
Traditional Chinese Medicine for Pediatric Allergic Diseases
Traditional Chinese Medicine for Pediatric Allergic Diseases
There is a clinically important and unmet need for long-term safe and effective preventative and therapeutic options for p...
Autoallergy and what the Allergist Needs to know
Autoallergy and what the Allergist Needs to know
This review aims to educate allergists about the concept of autoallergy by addressing five questions: 1) What is autoaller...
Targeting Arginine Metabolism in Immune Cells for the Treatment of Pulmonary Inflammatory Diseases
Targeting Arginine Metabolism in Immune Cells for the Treatment of Pulmonary Inflammatory Diseases
This review aims to provide a comprehensive overview of the role of arginine and its metabolic pathways in regulating immu...
Investigation into the Classification of Cough Sounds for Early Asthma Screening
Investigation into the Classification of Cough Sounds for Early Asthma Screening
This review aims to explore an effective and scalable approach for early asthma detection using cough sounds. The main obj...
The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions
The Roles of Acetylcholine and Muscarinic Receptors in Allergic Rhinitis: Mechanisms, Clinical Insights and Future Directions
Allergic rhinitis (AR) is a very common and troubling disorder that severely affects patients’ quality of life. Ther...
Lymphoproliferative Disorders Mimicking Rheumatologic Disease: A Clinical Reasoning Perspective
Lymphoproliferative Disorders Mimicking Rheumatologic Disease: A Clinical Reasoning Perspective
Lymphoproliferative disorders encompass a variety of hematologic diseases that are increasingly recognized. Patients with ...
The Effect of Exercise on Asthma in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The Effect of Exercise on Asthma in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Asthma is a heterogeneous respiratory condition and a common childhood disease. The effects of exercise on childhood asthm...
4-Week Maintenance ICS-Formoterol versus ICS in Adults Newly Diagnosed Mild Asthma: Effects on Symptoms, Lung Function, and Inflammation
4-Week Maintenance ICS-Formoterol versus ICS in Adults Newly Diagnosed Mild Asthma: Effects on Symptoms, Lung Function, and Inflammation
This study aimed to determine whether patients with newly diagnosed mild asthma benefit more from initiating treatment wit...
Detection of Anaphylaxis Through the Cutaneous Barrier
Detection of Anaphylaxis Through the Cutaneous Barrier
The capacity to rapidly and objectively detect impending anaphylaxis is a crucial unmet need in food allergy, as clinical ...
Sarcoidosis in the Genomic Era: From Genetic Drivers to Tailored Therapies
Sarcoidosis in the Genomic Era: From Genetic Drivers to Tailored Therapies
This review aims to synthesize existing literature on the genetics of sarcoidosis, including the genetic architectures ass...
Phenotypic Features of Central Compartment Atopic Disease Compared with Other Types of Chronic Rhinosinusitis: A Systematic Review
Phenotypic Features of Central Compartment Atopic Disease Compared with Other Types of Chronic Rhinosinusitis: A Systematic Review
Central Compartment Atopic Disease (CCAD) is an emerging phenotype of chronic rhinosinusitis. The absence of a standardize...
Microneedles in Allergy Immunotherapy: the Present and Future
Microneedles in Allergy Immunotherapy: the Present and Future
This review highlights current limitations of allergen-specific immunotherapy (AIT) methods and introduces microneedles (M...
Organotypic Airway Models Derived from Primary Human Nasal Epithelial Cells
Organotypic Airway Models Derived from Primary Human Nasal Epithelial Cells
The respiratory system is essential for gas exchange and immune defense but is highly susceptible to pathogens and harmful...
What is New in Contact Allergy To Cosmetics for Physicians, Cosmetologists, and Cosmetic Users?
What is New in Contact Allergy To Cosmetics for Physicians, Cosmetologists, and Cosmetic Users?
This paper aims to evaluate the burden of contact allergy caused by cosmetic products, identifying the key allergens invol...
Using the Electronic Health Record to Facilitate Drug Allergy Delabeling
Using the Electronic Health Record to Facilitate Drug Allergy Delabeling
There is a growing number of allergy delabeling programs across diverse clinical specialties and care settings. The electr...
Dendritic Cells: at the Crossroads between Oral Tolerance and Food Allergy
Dendritic Cells: at the Crossroads between Oral Tolerance and Food Allergy
Dendritic cells are specialized antigen presenting cells that bridge innate and adaptive immune responses. Here, we focus ...
Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 1 – Aeroallergen Protein Families
Can Physicochemical Properties Alter the Potency of Aeroallergens? Part 1 – Aeroallergen Protein Families
Respiratory allergies are non-communicable diseases caused by the hypersensitivity of the immune system to environmental a...
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases
Bone morphogenetic protein 2 (BMP2) belongs to the transforming growth factor-β (TGF-β) superfamily and plays an...
Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review
Treatment of COVID-19 Associated Olfactory Dysfunction: A Systematic Review
COVID -19 associated olfactory dysfunction is widespread, yet effective treatment strategies remain unclear. This article ...
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Mast Cells and Mas-related G Protein-coupled Receptor X2: Itching for Novel Pathophysiological Insights to Clinical Relevance
Clinical interest in non-IgE activation of mast cells has been growing since the description of the human MRGPRX2 receptor...
Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Effect of Treatment with Emphasis on Biological Therapy
Olfactory Dysfunction in Chronic Rhinosinusitis with Nasal Polyps: Effect of Treatment with Emphasis on Biological Therapy
Olfactory dysfunction significantly impacts quality of life that affects a majority of the patients with chronic rhinosinu...
Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps
Thymic Stromal Lymphopoietin (TSLP): Evidence in Respiratory Epithelial-driven Diseases Including Chronic Rhinosinusitis with Nasal Polyps
Thymic stromal lymphopoietin (TSLP) is increasingly recognized for its pivotal role in the pathogenesis of various epithel...
Effects of Food Processing on Allergenicity
Effects of Food Processing on Allergenicity
There is an increasing awareness among clinicians that industrial and household food processing methods can increase or de...
Parosmia: Pathophysiology and Management
Parosmia: Pathophysiology and Management
Parosmia is a qualitative olfactory disorder in which there is a mismatch between the memory of an odor and the actual exp...
The Impact of the Indoor Environment on Childhood Asthma
The Impact of the Indoor Environment on Childhood Asthma
This manuscript reviews the impact of important indoor environmental exposures on pediatric asthma, with a focus on recent...
Hypersensitivity Reactions to Anticonvulsants
Hypersensitivity Reactions to Anticonvulsants
Antiepileptics are the mainstay of treatment for seizure management. Immediate and delayed hypersensitivity reactions asso...
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis
Effect of Dupilumab in CRSwNP Sinonasal Outcomes from Real Life Studies: A Systematic Review with Meta-analysis
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory condition that significantly impacts qual...
Burden of Respiratory Syncytial Virus Disease in Adults with Asthma and Chronic Obstructive Pulmonary Disease: A Systematic Literature Review
Burden of Respiratory Syncytial Virus Disease in Adults with Asthma and Chronic Obstructive Pulmonary Disease: A Systematic Literature Review
Accumulating data indicate that asthma and chronic obstructive pulmonary disease (COPD) increase the risk of severe respir...
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