Systemic Autoimmune Rheumatic Disease-Associated Interstitial Lung Disease: A Pulmonary Perspective on Recent Guidelines

Panagopoulos P, Goules A, Hoffmann-Vold AM, Matteson EL, Tzioufas A. Natural history and screening of interstitial lung disease in systemic autoimmune rheumatic disorders. Ther Adv Musculoskelet Dis. 2021;13:1759720X211037519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeganathan N, Sathananthan M. Connective tissue disease-related interstitial lung disease: prevalence, patterns, predictors, prognosis, and treatment. Lung. 2020;198(5):735–59.

Article  PubMed  Google Scholar 

Palmucci S, Galioto F, Fazio G, et al. Clinical and radiological features of lung disorders related to connective-tissue diseases: a pictorial essay. Insights Imag. 2022;13(1):108.

Article  Google Scholar 

Johnson SR, Bernstein EJ, Bolster MB, et al. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) guideline for the treatment of interstitial lung disease in people with systemic autoimmune rheumatic diseases. Arthr Rheumatol. 2024;76(8):1182–200.

Article  Google Scholar 

Atzeni F, Gerardi MC, Barilaro G, Masala IF, Benucci M, Sarzi-Puttini P. Interstitial lung disease in systemic autoimmune rheumatic diseases: a comprehensive review. Expert Rev Clin Immunol. 2018;14(1):69–82.

Article  CAS  PubMed  Google Scholar 

Atienza-Mateo B, Remuzgo-Martínez S, Mora Cuesta VM, et al. The spectrum of interstitial lung disease associated with autoimmune diseases: data of a 3.6-year prospective study from a referral center of interstitial lung disease and lung transplantation. J Clin Med. 2020;9(6):1606.

Article  PubMed  PubMed Central  Google Scholar 

Fischer A, Distler J. Progressive fibrosing interstitial lung disease associated with systemic autoimmune diseases. Clin Rheumatol. 2019;38(10):2673–81.

Article  PubMed  Google Scholar 

Ng K-H, Chen D-Y, Lin C-H, et al. Risk of interstitial lung disease in patients with newly diagnosed systemic autoimmune rheumatic disease: a nationwide, population-based cohort study. Semin Arthritis Rheum; 2020: Elsevier; 2020. p. 840–5.

Hoffmann-Vold A-M, Maher TM, Philpot EE, et al. The identification and management of interstitial lung disease in systemic sclerosis: evidence-based European consensus statements. The Lancet Rheumatol. 2020;2(2):e71–83.

Article  CAS  PubMed  Google Scholar 

Perelas A, Silver RM, Arrossi AV, Highland KB. Systemic sclerosis-associated interstitial lung disease. Lancet Respir Med. 2020;8(3):304–20.

Article  CAS  PubMed  Google Scholar 

Jandali B, Salazar GA, Hudson M, et al. The effect of anti‐Scl‐70 antibody determination method on its predictive significance for interstitial lung disease progression in systemic sclerosis. ACR Open Rheumatol. 2022;4(4):345–51.

Article  PubMed  PubMed Central  Google Scholar 

Barba T, Mainbourg S, Nasser M, Lega J-C, Cottin V. Lung diseases in inflammatory myopathies. Seminars in Respiratory and Critical Care Medicine; 2019: Thieme Medical Publishers; 2019. p. 255–70.

Marie I, Josse S, Hatron P, et al. Interstitial lung disease in anti-Jo‐1 patients with antisynthetase syndrome. Arthritis Care Res. 2013;65(5):800–8.

Article  CAS  Google Scholar 

Laria A, Lurati AM, Zizzo G, et al. Interstitial lung disease in rheumatoid arthritis: a practical review. Front Med. 2022;9:837133.

Article  Google Scholar 

Manfredi A, Cassone G, Luppi F, et al. Rheumatoid arthritis related interstitial lung disease. Expert Rev Clin Immunol. 2021;17(5):485–97.

Article  CAS  PubMed  Google Scholar 

Khan T, Jose RJ, Renzoni EA, Mouyis M. A closer look at the role of anti-CCP antibodies in the pathogenesis of rheumatoid arthritis-associated interstitial lung disease and bronchiectasis. Rheumatol Ther. 2021;8(4):1463–75.

Article  PubMed  PubMed Central  Google Scholar 

Reiseter S, Gunnarsson R, Mogens Aaløkken T, et al. Progression and mortality of interstitial lung disease in mixed connective tissue disease: a long-term observational nationwide cohort study. Rheumatology. 2018;57(2):255–62.

Article  CAS  PubMed  Google Scholar 

Luppi F, Sebastiani M, Silva M, et al. Interstitial lung disease in Sjögren’s syndrome: a clinical review. Clin Exp Rheumatol. 2020;38(Suppl 126):291–300.

PubMed  Google Scholar 

Mageau A, Borie R, Crestani B, Timsit JF, Papo T, Sacre K. Epidemiology of interstitial lung disease in systemic lupus erythematosus in France: a nation‐wide population‐based study over 10 years. Respirology. 2022;27(8):630–4.

Article  PubMed  PubMed Central  Google Scholar 

Biciusca V, Rosu A, Stan SI, et al. A practical multidisciplinary approach to identifying interstitial lung disease in systemic autoimmune rheumatic diseases: a clinician’s narrative review. Diagnostics. 2024;14(23):2674.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Distler JH, Gabrielli A, Mayes MD. Guidance for the management of SARD-ILDs in clinical practice—impact of the ERS/EULAR recommendations. Ann Rheum Dis. 2026;85(2):219–22.

Article  PubMed  Google Scholar 

Li X, Liu Y, Cheng L, et al. Roles of biomarkers in anti‐MDA5‐positive dermatomyositis, associated interstitial lung disease, and rapidly progressive interstitial lung disease. J Clin Lab Anal. 2022;36(11):e24726.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rajan SK, Cottin V, Dhar R, et al. Progressive pulmonary fibrosis: an expert group consensus statement. Eur Respir J. 2023. https://doi.org/10.1183/13993003.03187-2021.

Article  PubMed  PubMed Central  Google Scholar 

Sethi PP, Gupta AK, Sudan A, et al. Efficacy and safety of nintedanib in interstitial lung disease associated with systemic autoimmune rheumatic diseases: a systematic review and meta-analysis. Indian J Rheumatol. 2026. https://doi.org/10.1177/09733698251403238.

Article  Google Scholar 

Cottin V, Crestani B, Valeyre D, et al. Diagnosis and management of idiopathic pulmonary fibrosis: french practical guidelines. Eur Respir Rev. 2014;23(132):193–214.

Article  PubMed  PubMed Central  Google Scholar 

Drimus JC, Duma RC, Trăilă D, Mogoșan CD, Manolescu DL, Fira-Mladinescu O. High-resolution CT findings in interstitial lung disease associated with connective tissue diseases: differentiating patterns for clinical practice—a systematic review with meta-analysis. J Clin Med. 2025;14(17):6164.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laporte A, Mariampillai K, Allenbach Y, et al. Idiopathic inflammatory myopathies: CT characteristics of interstitial lung disease and their association(s) with myositis-specific auto-antibodies. Eur Radiol. 2022. https://doi.org/10.1007/s00330-021-08411-w.

Article  PubMed  Google Scholar 

Flament T, Bigot A, Chaigne B, Henique H, Diot E, Marchand-Adam S. Pulmonary manifestations of Sjögren’s syndrome. Eur Respir Rev. 2016. https://doi.org/10.1183/16000617.0011-2016.

Article  PubMed  PubMed Central  Google Scholar 

Martinez FJ. Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia. Proc Am Thorac Soc. 2006;3(1):81–95.

Article  CAS  PubMed  Google Scholar 

Travis WD, Costabel U, Hansell DM, et al. An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med. 2013;188(6):733–48.

Article  PubMed  PubMed Central  Google Scholar 

Boyle N, Miller J, Quinn S, et al. Systemic autoimmune rheumatic diseases-associated interstitial lung disease: a pulmonologist’s perspective. Breathe. 2025. https://doi.org/10.1183/20734735.0171-2024.

Article  PubMed  PubMed Central  Google Scholar 

Sweis JJG, Sweis NWG, Alnaimat F, et al. Immune-mediated lung diseases: a narrative review. Front Med (Lausanne). 2023;10:1160755.

Article  PubMed  PubMed Central  Google Scholar 

De Zorzi E, Spagnolo P, Cocconcelli E, et al. Thoracic involvement in systemic autoimmune rheumatic diseases: pathogenesis and management. Clin Rev Allergy Immunol. 2022;63(3):472–89.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif