Hybrid procedures in cardiovascular medicine represent a rapidly evolving paradigm that bridges conventional open surgery with transcatheter and minimally invasive interventions. This Collection is dedicated to evaluating how these hybrid strategies can improve outcomes in patients with complex coronary, vascular, structural, and congenital heart disease. It also includes selected transcatheter interventions in which hybrid approaches may be particularly promising or clinically advantageous.

By combining surgical and endovascular techniques within single-stage or staged strategies, hybrid interventions enable individualized treatment tailored to anatomical complexity and clinical risk, with the potential to improve safety, reduce procedural burden, and accelerate recovery. The Collection aims to consolidate evidence on indications, procedural techniques, perioperative management, complications, and patient selection across the full spectrum of hybrid cardiovascular therapies.

The growing importance of hybrid cardiovascular interventions reflects major advances in imaging, device technology, and procedural planning, which have expanded the feasibility of treating increasingly complex disease. In parallel, structured collaboration between interventional cardiologists, cardiac surgeons, imaging specialists, and anesthesiologists has become central to optimizing procedural planning and outcomes. These multidisciplinary frameworks are essential to defining best practices and ensuring reproducibility across centres. Further research in this field may refine these collaborative models and contribute to the standardization of hybrid strategies in routine clinical practice.

Looking ahead, continued innovation is expected to further transform the field, with emerging roles for robotics, advanced imaging integration, computational modelling, and artificial intelligence–assisted decision-making. These developments may enhance procedural precision, expand indications for hybrid approaches, and support broader clinical dissemination. In addition, structured training pathways will be essential to equip the next generation of cardiovascular specialists with the skills required to safely and effectively perform hybrid interventions.

We welcome submissions across the full spectrum of hybrid cardiovascular medicine, including but not limited to:

Advances in endovascular and combined surgical–transcatheter procedures Multidisciplinary heart team approaches in hybrid interventions Challenges and innovations in congenital and structural heart defect repair Hybrid strategies in electrophysiology and ablation techniques Transcatheter interventions where hybrid strategies may offer particular promise or added value

All manuscripts submitted to this journal, including those submitted to collections and special issues, are assessed in line with our editorial policies and the journal’s peer review process. Reviewers and editors are required to declare competing interests and can be excluded from the peer review process if a competing interest exists.