Wells SA (2016) Progress in endocrine neoplasia. Clin Cancer Res 22(20):4981–4988
Article CAS PubMed PubMed Central Google Scholar
Morris LGT, Sikora AG, Tosteson TD, Davies L (2013) The increasing incidence of thyroid cancer: the influence of access to care. Thyroid 23(7):885–891
Article PubMed PubMed Central Google Scholar
Tang Z, Zhang J, Zhou Q, Xu S, Cai Z, Jiang G (2020) Thyroid cancer epidemic: a socio-environmental health problem needs collaborative efforts. Environ Sci Technol 54(7):3725–3727
Article CAS PubMed Google Scholar
Kruger E, Toraih EA, Hussein MH, Shehata SA, Waheed A, Fawzy MS, Kandil E (2022) Thyroid carcinoma: a review for 25 years of environmental risk factors studies. Cancers. https://doi.org/10.3390/cancers14246172
Article PubMed PubMed Central Google Scholar
Forma A, Kłodnicka K, Pająk W, Flieger J, Teresińska B, Januszewski J, Baj J (2025) Thyroid cancer: epidemiology, classification, risk factors, diagnostic and prognostic markers, and current treatment strategies. Int J Mol Sci. https://doi.org/10.3390/ijms26115173
Article PubMed PubMed Central Google Scholar
Huang H, Yan D, Liu W, Liu S, Xu Z, Wang X (2022) Isthmectomy is effective and sufficient for selected patients with the isthmus-confined solitary papillary thyroid carcinoma. Asian J Surg 45(9):1678–1681
Su H, Yang F, Wang Z, Ji X, Shao L, Zhu L, Zhang H, Zhang W, Sun W (2025) Meta-analysis of secondary hematologic malignancy risks following radioactive iodine therapy for differentiated thyroid cancer. Int J Surg 111(10):7312–7321
Article PubMed PubMed Central Google Scholar
Boucai L, Zafereo M, Cabanillas, ME (2024) Thyroid Cancer. Jama 331 (5).
Lyu YS, Pyo JS, Cho WJ, Kim SY, Kim JH (2021) Clinicopathological significance of papillary thyroid carcinoma located in the isthmus: a meta-analysis. World J Surg 45(9):2759–2768
Wang B, Zhu C-R, Wen H, Fei Y, Wu Z-J, Liu H, Yao X-M, Wu J (2025) Lobectomy with ipsilateral central lymph node dissection might be an appropriate surgical method for select cases of isthmic papillary thyroid carcinoma: a retrospective study with propensity scores matching analysis. Front Endocrinol. https://doi.org/10.3389/fendo.2025.1588323
Verma H, Shah N, Jain P, Manikantan K, Sharan R, Arun P (2022) Factors predicting contralateral nodal spread in papillary carcinoma of thyroid. Indian J Cancer 59(2):212–217
Feng J-W, Qu Z, Ye J, Hong L-Z, Liu S-Y, Wang F, Jiang Y, Hu J (2021) Nomograms to predict ipsilateral and contralateral central lymph node metastasis in clinically lymph node-negative patients with solitary isthmic classic papillary thyroid carcinoma. Surgery 170(6):1670–1679
Lee S, Kim S-j, Choi JY, Park N, Kim J, Kong Y, Bae HL, Lee JK, Kim W, Yu HW, Chai YJ, Lee KE (2025) Comparative study of clinical outcomes for total thyroidectomy/lobectomy and isthmusectomy in patients with isthmic papillary thyroid carcinoma. Thyroid 35(11):1322–1330
Gui Z, Wang Z, Xiang J, Sun W, He L, Dong W, Huang J, Zhang D, Lv C, Qin Y, Zhang T, Shao L, Zhang P, Zhang H, (2020) Comparison of Outcomes Following Thyroid Isthmusectomy, Unilateral Thyroid Lobectomy, and Total Thyroidectomy in Patients with Papillary Thyroid Microcarcinoma of the Thyroid Isthmus: A Retrospective Study at a Single Center. Medical Science Monitor, 26.
Chai YJ, Kim S, Choi JY, Koo DH, Lee KE, Youn YK (2013) Papillary thyroid carcinoma located in the isthmus or upper third is associated with delphian lymph node metastasis. World J Surg 38(6):1306–1311
Gong H, Jiang Y, Su A (2023) Total thyroidectomy versus less-than-total thyroidectomy for papillary thyroid carcinoma of isthmus: a systematic review and meta-analysis. Gland Surg 12(11):1525–1540
Article PubMed PubMed Central Google Scholar
Erratum to pathological analysis and surgical modalities selection of cT1N0M0 solitary papillary thyroid carcinoma in the isthmus. Gland Surgery 2021, 10 (11), 3167–3168.
Wang J, Sun H, Gao L, Xie L, Cai X, (2015) Evaluation of thyroid isthmusectomy as a potential treatment for papillary thyroid carcinoma limited to the isthmus: A clinical study of 73 patients. Head & Neck 38 (S1).
Vasileiadis I, Boutzios G, Karalaki M, Misiakos E, Karatzas T (2018) Papillary thyroid carcinoma of the isthmus: total thyroidectomy or isthmusectomy? Am J Surg 216(1):135–139
Cao M, Yu T, Miao X, Wu Z, Wang W (2024) The preferred surgical choice for intermediate-risk papillary thyroid cancer: total thyroidectomy or lobectomy? A systematic review and meta-analysis. Int J Surg 110(8):5087–5100
Article PubMed PubMed Central Google Scholar
Wu C-W (2020) Investigation of the role of thyroid isthmusectomy for solitary isthmic papillary thyroid carcinoma. J Investig Surg 34(10):1135–1136
Hemmingsen B, Christensen LL, Wetterslev J, Vaag A, Gluud C, Lund SS, Almdal T (2012) Comparison of metformin and insulin versus insulin alone for type 2 diabetes: systematic review of randomised clinical trials with meta-analyses and trial sequential analyses. BMJ 344:e1771–e1771
Seo HW, Song CM, Ji YB, Jeong JH, Koo HR, Tae K (2020) Surgical outcomes and efficacy of isthmusectomy in single isthmic papillary thyroid carcinoma: a preliminary retrospective study. J Investig Surg 34(10):1129–1134
Yuan Q, Li C, Zhou R, Hou J, Li J, Wu G (2025) Prognosis and postoperative complications of wide-field isthmusectomy for node-negative papillary thyroid carcinoma limited to the isthmus. J Otolaryngol Head Neck Surg. https://doi.org/10.1177/19160216251348423
Article PubMed PubMed Central Google Scholar
Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 339:b2535–b2535
Article PubMed PubMed Central Google Scholar
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2020) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71
Zhu J, Xu J, Qu H, Hao J, Zhang L, Liu J (2025) A preliminary exploration of surgical strategies for solitary papillary thyroid carcinoma on the isthmus. Oral Oncol. https://doi.org/10.1016/j.oraloncology.2025.107511
Zhu J, Lei J, Li Z, Gong R, Wei T (2016) Surgical procedures for papillary thyroid carcinoma located in the thyroid isthmus: an intention-to-treat analysis. OncoTargets Ther 9:5209–5216
Dan J, Tan J, Guo Y, Xu Y, Chen J, Huang J (2024) Isthmusectomy for papillary thyroid carcinoma in the isthmus: the less the better. Asian J Surg 47(1):367–372
Kwon O, Lee S, Bae JS, Jung CK (2021) Thyroid isthmusectomy with prophylactic central compartment neck dissection is a feasible approach for papillary thyroid cancer on the isthmus. Ann Surg Oncol 28(11):6603–6612
Ringel MD, Sosa JA, Baloch Z, Bischoff L, Bloom G, Brent GA, Brock PL, Chou R, Flavell RR, Goldner W, Grubbs EG, Haymart M, Larson SM, Leung AM, Osborne J, Ridge JA, Robinson B, Steward DL, Tufano RP, Wirth LJ (2025) American thyroid association management guidelines for adult patients with differentiated thyroid cancer. Thyroid 35(8):841–985
Article CAS PubMed PubMed Central Google Scholar
Dobrinja C, Samardzic N, Giudici F, Raffaelli M, De Crea C, Sessa L, Docimo G, Ansaldo GL, Minuto M, Varaldo E, Dionigi G, Spiezia S, Boniardi M, Pauna I, De Pasquale L, Testini M, Gurrado A, Pasculli A, Pezzolla A, Lattarulo S, Calò PG, Graceffa G, Massara A, Docimo L, Ruggiero R, Parmeggiani D, Iacobone M, Innaro N, Lombardi CP, de Manzini N (2021) Hemithyroidectomy versus total thyroidectomy in the intermediate-risk differentiated thyroid cancer: the Italian societies of endocrine surgeons and surgical oncology multicentric study. Updates Surg 73(5):1909–1921
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