Sakamoto K, Yanagisawa R, Ono R, Doi T, Negishi T, Kada A, et al. Risk-stratified phase II clinical trial for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in pediatric, adolescent, and young adult patients in Japan. Pediatr Blood Cancer. 2025. https://doi.org/10.1002/pbc.32166.
Yanagisawa R, Nakazawa Y, Matsuda K, Yasumi T, Kanegane H, Ohga S, et al. Outcomes in children with hemophagocytic lymphohistiocytosis treated using HLH-2004 aprotocol in Japan. Int J Hematol. 2019;109:206–13.
Article CAS PubMed Google Scholar
Henter J-I, Samuelsson-Horne A, Aricò M, Egeler RM, Elinder G, Filipovich AH, et al. Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation. Blood. 2002;100:2367–73.
Article CAS PubMed Google Scholar
Henter J-I, Horne A, Aricó M, Egeler RM, Filipovich AH, Imashuku S, et al. HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2007;48:124–31.
Kimura H, Kwong Y-L. EBV viral loads in diagnosis, monitoring, and response assessment. Front Oncol. 2019;9:62.
Article PubMed PubMed Central Google Scholar
Kanakry JA, Hegde AM, Durand CM, Massie AB, Greer AE, Ambinder RF, et al. The clinical significance of EBV DNA in the plasma and peripheral blood mononuclear cells of patients with or without EBV diseases. Blood. 2016;127:2007–17.
Article CAS PubMed PubMed Central Google Scholar
Zhang P, Zeng C, Cheng J, Zhou J, Gu J, Mao X, et al. Determination of Epstein-Barr virus-infected lymphocyte cell types in peripheral blood mononuclear cells as a valuable diagnostic tool in hematological diseases. Open Forum Infect Dis. 2019;6:ofz171.
Article PubMed PubMed Central Google Scholar
Zhang W, Yin Y, Li Y, Cheng L, Zhao L, Peng Y, et al. Clinical utility of plasma Epstein-Barr virus DNA monitoring in pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a Chinese retrospective observational study. Ital J Pediatr. 2024;50:139.
Article CAS PubMed PubMed Central Google Scholar
Matsuda K, Nakazawa Y, Yanagisawa R, Honda T, Ishii E, Koike K. Detection of T-cell receptor gene rearrangement in children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis using the BIOMED-2 multiplex polymerase chain reaction combined with GeneScan analysis. Clin Chim Acta. 2011;412:1554–8.
Article CAS PubMed Google Scholar
Furui Y, Sakamoto K, Okura E, Hirabayashi K, Saito S, Yanagisawa R, et al. Dynamics of EBV-DNA load across sample types in pediatric EBV-HLH. Int J Hematol. 2025. https://doi.org/10.1007/s12185-025-04026-9.
Furui Y, Sakamoto K, Okura E, Hirabayashi K, Saito S, Yanagisawa R, et al. Persistent low-level EBV-DNA detection in non-plasma compartments during convalescence after pediatric EBV-HLH. Int J Hematol. 2026. https://doi.org/10.1007/s12185-026-04169-3.
Yanagaisawa R, Matsuda K, Ohga S, Kanegane H, Morimoto A, Okamoto Y, et al. Factors predicting the recurrence of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in children after treatment using the HLH-2004 protocol. Int J Hematol. 2004;109:612–7.
Kasahara Y, Yachie A, Takei K, Kanegane C, Okada K, Ohta K, et al. Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infection. Blood. 2001;98:1882–8.
Article CAS PubMed Google Scholar
Chellapandian D, Das R, Zelley K, Wiener SJ, Zhao H, Teachey DT, et al. Treatment of Epstein Barr virus-induced haemophagocytic lymphohistiocytosis with rituximab-containing chemo-immunotherapeutic regimens. Br J Haematol. 2013;162:376–82.
Article CAS PubMed PubMed Central Google Scholar
Meng G-Q, Wang J-S, Wang Y-N, Wei N, Wang Z. Rituximab-containing immuno-chemotherapy regimens are effective for the elimination of EBV for EBV-HLH with only and mainly B lymphocytes of EBV infection. Int Immunopharmacol. 2021;96:107606.
Comments (0)