Identifying natural products for gastric cancer treatment through pharmacophore creation, 3D QSAR, virtual screening, and molecular dynamics studies

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2018;68(6):394–424.

Article  Google Scholar 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A, et al. Cancer statistics for the year 2020: an overview. Int J Cancer. 2021;149(4):778–89.

Article  CAS  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49.

Article  Google Scholar 

Zaafouri H, Jouini R, Khedhiri N, Khanchel F, Cherif M, Mesbahi M, et al. Comparison between signet-ring cell carcinoma and non-signet-ring cell carcinoma of the stomach: clinicopathological parameters, epidemiological data, outcome, and prognosis—a cohort study of 123 patients from a non-endemic country. World J Surg Oncol. 2022;20(1):1–12.

Article  Google Scholar 

Liu D, Zhang R, Chen S, Sun B, Zhang K. Analysis of gastric microbiome reveals three distinctive microbial communities associated with the occurrence of gastric cancer. BMC Microbiol. 2022;22(1):1–13.

Article  CAS  Google Scholar 

Jiang X-j, Lin J, Cai Q-h, Zhao J-f, Zhang H-j. CDH17 alters MMP-2 expression via canonical NF-κB signalling in human gastric cancer. Gene. 2019;682:92–100.

Article  CAS  PubMed  Google Scholar 

Yang Y, Chen Y, Hu Y, Feng Y, Mao Q, Xue W. Outcomes of laparoscopic versus open total gastrectomy with D2 lymphadenectomy for gastric cancer: a systematic review and meta-analysis. Eur J Med Res. 2022;27(1):1–9.

Article  Google Scholar 

Shi J, Li N, Tang Y, Jiang L, Yang L, Wang S, et al. Total neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial. BMC Gastroenterol. 2022;22(1):1–9.

Article  CAS  Google Scholar 

Lee HJ, Venkatarame Gowda Saralamma V, Kim SM, Ha SE, Vetrivel P, Kim EH, et al. Comparative proteomic profiling of tumor-associated proteins in human gastric cancer cells treated with pectolinarigenin. Nutrients. 2018;10(11): 1596.

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Zhi Q, Liu S, Xue S-L, Shen C, Li Y, et al. Identification of specific biomarkers for gastric adenocarcinoma by ITRAQ proteomic approach. Sci Rep. 2016;6(1):1–15.

Google Scholar 

Zhu AK, Shan YQ, Zhang J, Liu XC, Ying RC, Kong WC. Exosomal NNMT from peritoneum lavage fluid promotes peritoneal metastasis in gastric cancer. Kaohsiung J Med Sci. 2021;37(4):305–13.

Article  PubMed  Google Scholar 

Chen Y, Ye B, Wang C, Nie Y, Qin J, Shen Z. PLOD3 contributes to HER-2 therapy resistance in gastric cancer through FoxO3/Survivin pathway. Cell Death Discovery. 2022;8(1):1–12.

Article  Google Scholar 

Zhao S, Bi Y, Wang Z, Zhang F, Zhang Y, Xu Y. Accuracy evaluation of combining gastroscopy, multi-slice spiral CT, Her-2, and tumor markers in gastric cancer staging diagnosis. World J Surg Oncol. 2022;20(1):1–10.

Article  Google Scholar 

Lordick F, Kang Y-K, Chung H-C, Salman P, Oh SC, Bodoky G, et al. Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. Lancet Oncol. 2013;14(6):490–9.

Article  CAS  PubMed  Google Scholar 

Wang Y, Yin X, Chen L, Yin Z, Zuo Z. Discovery and evaluation of cytisine N-isoflavones as novel EGFR/HER2 dual inhibitors. Bioorg Chem. 2022;127: 105868.

Article  CAS  PubMed  Google Scholar 

Xu S, Chen W, Wang Y, Zhang Y, Xia R, Shen J, et al. N6-methyladenosine-related lncRNAs identified as potential biomarkers for predicting the overall survival of asian gastric cancer patients. BMC Cancer. 2022;22(1):1–18.

Article  CAS  Google Scholar 

Ohtsu A, Shah MA, Van Cutsem E, Rha SY, Sawaki A, Park SR, et al. Bevacizumab in combination with chemotherapy as first-line therapy in advanced gastric cancer: a randomized, double-blind, placebo-controlled phase III study. J Clin Oncol. 2011;29(30):3968–76.

Article  CAS  PubMed  Google Scholar 

Chu X-d, Lin Z-b, Huang T, Ding H, Zhang Y-r, Zhao Z, et al. Thrombospondin-2 holds prognostic value and is associated with metastasis and the mismatch repair process in gastric cancer. BMC Cancer. 2022;22(1):1–13.

Article  Google Scholar 

Iveson T, Donehower RC, Davidenko I, Tjulandin S, Deptala A, Harrison M, et al. Rilotumumab in combination with epirubicin, cisplatin, and capecitabine as first-line treatment for gastric or oesophagogastric junction adenocarcinoma: an open-label, dose de-escalation phase 1b study and a double-blind, randomised phase 2 study. Lancet Oncol. 2014;15(9):1007–18.

Article  CAS  PubMed  Google Scholar 

Anestis A, Zoi I, Karamouzis MV. Current advances of targeting HGF/c-Met pathway in gastric cancer. Ann Transl Med. 2018;6(12):247.

Yuan J, Tan L, Yin Z, Tao K, Wang G, Shi W, et al. Glis2 redundancy causes chemoresistance and poor prognosis of gastric cancer based on co–expression network analysis. Oncol Rep. 2019;41(1):191–201.

CAS  PubMed  Google Scholar 

Kim HK, Reyzer ML, Choi IJ, Kim CG, Kim HS, Oshima A, et al. Gastric cancer-specific protein profile identified using endoscopic biopsy samples via MALDI mass spectrometry. J Proteome Res. 2010;9(8):4123–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Chen J, Zuo Q, Wu C, Yu T, Zheng P, et al. Calreticulin enhances gastric cancer metastasis by dimethylating H3K9 in the E-cadherin promoter region mediating by G9a. Oncogenesis. 2022;11(1):1–11.

Article  Google Scholar 

Zhang L, Song M, Zhang F, Yuan H, Chang W, Yu G, et al. Accumulation of nicotinamide N-methyltransferase (NNMT) in cancer-associated fibroblasts: a potential prognostic and predictive biomarker for gastric carcinoma. J Histochem Cytochem. 2021;69(3):165–76.

Article  CAS  PubMed  Google Scholar 

Pozzi V, Campagna R, Sartini D, Emanuelli M. Nicotinamide N-methyltransferase as promising tool for management of gastrointestinal neoplasms. Biomolecules. 2022;12(9): 1173.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Okamoto W, Okamoto I, Yoshida T, Okamoto K, Takezawa K, Hatashita E, et al. Identification of c-Src as a potential therapeutic target for gastric Cancer and of MET activation as a cause of resistance to c-Src inhibitionc-src as a therapeutic target for gastric Cancer. Mol Cancer Ther. 2010;9(5):1188–97.

Article  CAS  PubMed  Google Scholar 

Nam H-J, Im S-A, Oh D-Y, Elvin P, Kim H-P, Yoon Y-K, et al. Antitumor Activity of Saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancerantitumor effects of saracatinib in gastric Cancer. Mol Cancer Ther. 2013;12(1):16–26.

Article  CAS  PubMed  Google Scholar 

Malpeli G, Barbi S, Innamorati G, Alloggio M, Filippini F, Decimo I, et al. Landscape of druggable molecular pathways downstream of genomic CDH1/Cadherin-1 alterations in gastric Cancer. J Personalized Med. 2022;12(12): 2006.

Article  Google Scholar 

Yan Q, Wu Y, Li D, Li Y. A-Kinase anchoring protein 9 promotes gastric cancer progression as a downstream effector of cadherin 1. J Oncology 2022:2830634.

Wanga X-z, Gu J-l, Gao M, Bian Y, Liang J-y, Wen H-m, et al. Peperomin E induces promoter hypomethylation of metastatic-suppressor genes and attenuates metastasis in poorly differentiated gastric Cancer. Cell Physiol. 2018;50(6):2341–64.

CAS  Google Scholar 

Ngabire D, Seong Y, Patil MP, Niyonizigiye I, Seo YB, Kim G-D. Induction of apoptosis and G1 phase cell cycle arrest by Aster incisus in AGS gastric adenocarcinoma cells. Int J Oncol. 2018;53(5):2300–8.

CAS  PubMed  Google Scholar 

Trinh TA, Lee D, Park S, Kim SH, Park JG, Kim JH, et al. Stilbenes contribute to the anticancer effects of Rheum undulatum L. through activation of apoptosis. Oncol Lett. 2019;17(3):2953–9.

CAS  PubMed  PubMed Central  Google Scholar 

Shukla S, Mehta A. Anticancer potential of medicinal plants and their phytochemicals: a review. Brazilian J Bot. 2015;38(2):199–210.

Article  Google Scholar 

Ashktorab H, Soleimani A, Singh G, Amin A, Tabtabaei S, Latella G, et al. Saffron: the golden spice with therapeutic properties on digestive diseases. Nutr Cancer. 2019;11(5):943.

CAS  Google Scholar 

Alibeiki F, Jafari N, Karimi M, Peeri Dogaheh H. Potent anti-cancer effects of less polar curcumin analogues on gastric adenocarcinoma and esophageal squamous cell carcinoma cells. Sci Rep. 2017;7(1):1–9.

Article  CAS  Google Scholar 

Ham I-H, Wang L, Lee D, Woo J, Kim TH, Jeong HY, et al. Curcumin inhibits the cancer–associated fibroblast–derived chemoresistance of gastric cancer through the suppression of the JAK/STAT3 signaling pathway. Int J Oncol. 2022;61(1):1–12.

Article  Google Scholar 

Mohammadi A, Khanbabaei H, Zandi F, Ahmadi A, Haftcheshmeh SM, Johnston TP et al. Curcumin: a therapeutic strategy for targeting the Helicobacter pylori-related diseases. Microb Pathog. 2022:105552.

Shang HS, Lu HF, Lee CH, Chiang HS, Chu YL, Chen A, et al. Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018;33(11):1168–81.

Article  CAS  PubMed  Google Scholar 

Sathianarayanan S, Aparna V, Biswas R, Anita B, Sukumaran S, Venkidasamy B. A new approach against Helicobacter pylori using plants and its constituents: a review study. Microb Pathog. 2022:168:105594.

Zhang Q, Wang X, Cao S, Sun Y, He X, Jiang B, et al. Berberine represses human gastric cancer cell growth in vitro and in vivo by inducing cytostatic autophagy via inhibition of MAPK/mTOR/p70S6K and akt signaling pathways. Biomed Pharmacother. 2020;128: 110245.

Article  CAS  PubMed  Google Scholar 

Li L-L, Peng Z, Hu Q, Xu L-J, Zou X, Huang D-M, et al. Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α. World J Gastrointest Oncol. 2022;14(4): 842.

Article  PubMed  PubMed Central  Google Scholar 

Tsai C-L, Chiu Y-M, Ho T-Y, Hsieh C-T, Shieh D-C, Lee Y-J, et al. Gallic acid induces apoptosis in human gastric adenocarcinoma cells. Anticancer Res. 2018;38(4):2057–67.

CAS  PubMed  Google Scholar 

Kim S, Kim W, Kim D-H, Jang J-H, Kim S-J, Park S-A, et al. Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition of PIM-1 kinase activity. Arch Biochem. 2020;689: 108413.

Comments (0)

No login
gif