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Eugenol mitigates schizophrenia-like behavioral deficits, oxidative stress, apoptosis, neuroinflammation, and cholinergic dysfunction in ketamine-induced mice
Eugenol mitigates schizophrenia-like behavioral deficits, oxidative stress, apoptosis, neuroinflammation, and cholinergic dysfunction in ketamine-induced mice
Schizophrenia, a severe neurodevelopmental disorder, is influenced by oxidative stress, neuroinflammation, apoptosis, and ...
The NLRP3 inflammasome in osteoarthritis: a systematic review of traditional, complementary, and integrative medicine efficacy and underlying mechanisms
The NLRP3 inflammasome in osteoarthritis: a systematic review of traditional, complementary, and integrative medicine efficacy and underlying mechanisms
Osteoarthritis (OA) is a degenerative joint condition mostly affecting the knees characterized by cartilage degradation, s...
Engineering microspheres for breast cancer: integrating tumor modeling, diagnostics, and targeted treatment
Engineering microspheres for breast cancer: integrating tumor modeling, diagnostics, and targeted treatment
Microsphere-based technologies have increasingly gained attention as adaptable and multifunctional tools in breast cancer ...
Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance
Tableting of nanoparticle-based formulations for oral delivery: Enhancing biopharmaceutical performance
This review critically examines the integration of nanocarriers into oral tablet formulations, focusing on compaction stra...
Pharmaceutically engineered olfactory-masking agents: Innovating oral drug delivery through multisensory excipient design
Pharmaceutically engineered olfactory-masking agents: Innovating oral drug delivery through multisensory excipient design
Enhancing patient adherence to oral medication administration is still exceedingly difficult, especially for sensitive, el...
ALKBH5 promotes the progression of cisplatin-resistant oral squamous cell carcinoma by regulating FOXA1 expression via mA RNA methylation
ALKBH5 promotes the progression of cisplatin-resistant oral squamous cell carcinoma by regulating FOXA1 expression via mA RNA methylation
Oral squamous cell carcinoma (OSCC) accounts for the vast majority of oral cancer cases. Accumulating evidence has implica...
Gastrodin as a nephroprotective agent: Molecular docking–based modulation of oxidative stress, fibrosis, and inflammation
Gastrodin as a nephroprotective agent: Molecular docking–based modulation of oxidative stress, fibrosis, and inflammation
Kidney diseases are a heterogeneous group of disorders characterised by progressive structural and functional impairment o...
The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis
The effects of resveratrol on glycemic indices and lipid profile in patients with type 2 diabetes: an umbrella review and meta-analysis
Growing evidence supports the therapeutic role of nutraceuticals as complementary and alternative therapies in patients wi...
The paradoxical protective effect of malnutrition in acetaminophen-induced liver injury
The paradoxical protective effect of malnutrition in acetaminophen-induced liver injury
Malnutrition is believed to aggravate drug-induced liver injury (DILI). However, the relationship between protein malnutri...
Plant-derived exosome-like nanovesicles as programmable bio-organic excipients: a next-generation platform for precision and immuno-silent drug delivery
Plant-derived exosome-like nanovesicles as programmable bio-organic excipients: a next-generation platform for precision and immuno-silent drug delivery
There is increasing demand for advanced drug delivery systems that improve therapeutic efficacy while minimizing toxicity....
A cost-efficient internal standard approach for busulfan quantification: MS-based investigation of adduct formation in therapeutic drug monitoring
A cost-efficient internal standard approach for busulfan quantification: MS-based investigation of adduct formation in therapeutic drug monitoring
Busulfan plays a central role in conditioning regimens for hematopoietic stem cell transplantation (HSCT). However, its na...
Cephaeline promotes ferroptosis in breast cancer via p53/SLC7A11/GPX4 axis
Cephaeline promotes ferroptosis in breast cancer via p53/SLC7A11/GPX4 axis
Cephaeline (CPL), a bioactive compound derived from the medicinal plant Ipecacuanha, has demonstrated inhibitory effects o...
Bio-guided identification of novel antiparasitic natural products from K. Schum (Rubiaceae)
Bio-guided identification of novel antiparasitic natural products from K. Schum (Rubiaceae)
Gardenia imperialis K. Schum. is a medicinal plant used in traditional medicine to treat malaria and related symptoms. Thi...
Aprepitant’s neuroprotective effects on methylphenidate-induced biochemical/mitochondrial dysfunction, neuroinflammation, and mood-related behavior alterations
Aprepitant’s neuroprotective effects on methylphenidate-induced biochemical/mitochondrial dysfunction, neuroinflammation, and mood-related behavior alterations
Chronic methylphenidate (MPH) use causes neurological and behavioral problems. Aprepitant (APR) has demonstrated neuroprot...
Chitosan-carboxymethyl tara gum polyelectrolyte complex matrix tablets for sustained gastrointestinal drug dissolution using paracetamol as a model drug
Chitosan-carboxymethyl tara gum polyelectrolyte complex matrix tablets for sustained gastrointestinal drug dissolution using paracetamol as a model drug
Natural polysaccharides are extensively used for delivery of bioactives because of its eco-friendly, biocompatible and bio...
Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives
Therapeutic targeting of COX-2 in head and neck cancer: Mechanistic and clinical perspectives
Cyclooxygenase-2 (COX-2) is a key player in inflammation; it is often over-activated in HNSCC, which consequently increase...
Bridging solubility, stability, and translation: advances in carbon nanotube–based drug delivery systems
Bridging solubility, stability, and translation: advances in carbon nanotube–based drug delivery systems
Poor aqueous solubility and physicochemical instability remain major barriers in pharmaceutical development, limiting the ...
Wistar rat model experiments for increasing intraocular pressure: a systematic review
Wistar rat model experiments for increasing intraocular pressure: a systematic review
Glaucoma is a leading cause of irreversible vision loss, with elevated intraocular pressure (IOP) being the primary modifi...
Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system
Relieving postherpetic neuralgia pain via gabapentin-loaded bigels as an auspicious topical drug delivery system
Over the past decades, a substantial portion of the population worldwide has been infected with varicella zoster and most ...
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
Rhinovirus (RV) infection is a major cause of common colds and asthma exacerbations, with no antiviral drug available. Cur...
Pharmacogenetic DPYD allele variant frequencies: A comprehensive analysis across an ancestrally diverse Iranian population
Pharmacogenetic DPYD allele variant frequencies: A comprehensive analysis across an ancestrally diverse Iranian population
Cancer treatment has improved over the past decades, but many cancer patients still experience adverse drug reactions (ADR...
Therapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review
Therapeutic role of erythropoietin in methanol induced optic neuropathy: a systematic review
Despite various therapeutic attempts, an approved treatment for Methanol-induced optic neuropathy (MION), a sight-threaten...
Advances in artificial intelligence-based technologies for increasing the quality of medical products
Advances in artificial intelligence-based technologies for increasing the quality of medical products
Artificial intelligence (AI) is a technology that combines machine learning (ML) and deep learning. It has numerous usages...
Cellular and molecular aspects of drug resistance in cancers
Cellular and molecular aspects of drug resistance in cancers
Cancer drug resistance is a multifaceted phenomenon. The present review article aims to comprehensively analyze the cellul...
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Development of amphotericin B inclusion complex formulation in dissolvable microarray patches for intravaginal delivery
Amphotericin B (AMB) is a drug used to treat vulvovaginal candidiasis (VVC), which is a fungal infection affecting the vag...
Trends analysis and future study of the pharmaceutical industry field: a scoping review
Trends analysis and future study of the pharmaceutical industry field: a scoping review
The main aim of this study was to explore and understand the emerging developments, changes, and patterns shaping the futu...
Electroceuticals: Unlocking the promise of therapies
Electroceuticals: Unlocking the promise of therapies
Electroceuticals refers to the constantly growing disciplines of bioelectric and bioelectronic medication. These include a...
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography method for measuring Captopril: an empirical study on hydrogel film permeability test
High-performance liquid chromatography (HPLC) has emerged as a highly sensitive and versatile analytical technique for qua...
and assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery
and assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery
Bile salts enriched nanovesicles (bilosomes) have been attention worthy in the past few years due to their distinctive eff...
Evaluation of the consumption pattern and efficacy of Linezolid in COVID-19 hospitalized patients in a hospital in Tehran-Iran
Evaluation of the consumption pattern and efficacy of Linezolid in COVID-19 hospitalized patients in a hospital in Tehran-Iran
The inappropriate use of antibiotics increases the costs of treatment, antibiotic resistance, increased disease length and...
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