Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study

Gu B, Shang X, Yan M, Li X, Wang W, Wang Q, Zhang C. Variations in incidence and mortality rates of endometrial cancer at the global, regional, and national levels, 1990–2019. Gynecol Oncol. 2021;161:573–80.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71:7–33.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48.

Article  PubMed  Google Scholar 

Long B, Lilyquist J, Weaver A, Hu C, Gnanaolivu R, Lee KY, Hart SN, Polley EC, Bakkum-Gamez JN, Couch FJ, Dowdy SC. Cancer susceptibility gene mutations in type I and II endometrial cancer. Gynecol Oncol. 2019;152:20–5.

Article  CAS  PubMed  Google Scholar 

Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983;15:10–7.

Article  CAS  PubMed  Google Scholar 

Urick ME, Bell DW. Clinical actionability of molecular targets in endometrial cancer. Nat Rev Cancer. 2019;19:510–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherman ME, Sturgeon S, Brinton LA, Potischman N, Kurman RJ, Berman ML, Mortel R, Twiggs LB, Barrett RJ, Wilbanks GD. Risk factors and hormone levels in patients with serous and endometrioid uterine carcinomas. Mod Pathol. 1997;10:963–8.

CAS  PubMed  Google Scholar 

Mendivil A, Schuler KM, Gehrig PA. Non-endometrioid adenocarcinoma of the uterine corpus: a review of selected histological subtypes. Cancer Control. 2009;16:46–52.

Article  PubMed  Google Scholar 

Joshi A, Miller C Jr, Baker SJ, Ellenson LH. Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion. Am J Pathol. 2015;185:1104–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

McConechy MK, Hoang LN, Chui MH, Senz J, Yang W, Rozenberg N, Mackenzie R, McAlpine JN, Huntsman DG, Clarke BA, Gilks CB, Lee CH. In-depth molecular profiling of the biphasic components of uterine carcinosarcomas. J Pathol Clin Res. 2015;1:173–85.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jones S, Stransky N, McCord CL, Cerami E, Lagowski J, Kelly D, Angiuoli SV, Sausen M, Kann L, Shukla M, Makar R, Wood LD, Diaz LA Jr, et al. Genomic analyses of gynaecologic carcinosarcomas reveal frequent mutations in chromatin remodelling genes. Nat Commun. 2014;5:5006.

Article  CAS  PubMed  Google Scholar 

Cherniack AD, Shen H, Walter V, Stewart C, Murray BA, Bowlby R, Hu X, Ling S, Soslow RA, Broaddus RR, Zuna RE, Robertson G, Laird PW, et al. Integrated molecular characterization of uterine carcinosarcoma. Cancer Cell. 2017;31:411–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dou Y, Kawaler EA, Cui Zhou D, Gritsenko MA, Huang C, Blumenberg L, Karpova A, Petyuk VA, Savage SR, Satpathy S, Liu W, Wu Y, Tsai CF, et al. Proteogenomic characterization of endometrial carcinoma. Cell. 2020;180:729-48.e26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Santoro A, Angelico G, Travaglino A, Inzani F, Arciuolo D, Valente M, D’Alessandris N, Scaglione G, Fiorentino V, Raffone A, Zannoni GF. New pathological and clinical insights in endometrial cancer in view of the updated ESGO/ESTRO/ESP guidelines. Cancers. 2021;13:2623.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Woude H, Hally KE, Currie MJ, Gasser O, Henry CE. Importance of the endometrial immune environment in endometrial cancer and associated therapies. Front Oncol. 2022;12:975201.

Article  PubMed  PubMed Central  Google Scholar 

Talhouk A, Derocher H, Schmidt P, Leung S, Milne K, Gilks CB, Anglesio MS, Nelson BH, McAlpine JN. Molecular subtype not immune response drives outcomes in endometrial carcinoma. Clin Cancer Res. 2019;25:2537–48.

Article  CAS  PubMed  Google Scholar 

Vanderstraeten A, Tuyaerts S, Amant F. The immune system in the normal endometrium and implications for endometrial cancer development. J Reprod Immunol. 2015;109:7–16.

Article  CAS  PubMed  Google Scholar 

Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366:2455–65.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morice P, Leary A, Creutzberg C, Abu-Rustum N, Darai E. Endometrial cancer. Lancet. 2016;387:1094–108.

Article  PubMed  Google Scholar 

Ren X, Wang MM, Wang G, Sun XM, Xia TT, Yao Y, Wang CC, Jiang AF, Wang H, Cao J, Wei YJ, Sun CG. A nomogram for predicting overall survival in patients with type II endometrial carcinoma: a retrospective analysis and multicenter validation study. Eur Rev Med Pharmacol Sci. 2023;27:233–47.

CAS  PubMed  Google Scholar 

Ebring C, Marlin R, Macni J, Vallard A, Bergerac S, Beaubrun-Renard M, Joachim C, Jean-Laurent M. Type II endometrial cancer: Incidence, overall and disease-free survival in Martinique. PLoS ONE. 2023;18:e0278757.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamilton CA, Cheung MK, Osann K, Chen L, Teng NN, Longacre TA, Powell MA, Hendrickson MR, Kapp DS, Chan JK. Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers. Br J Cancer. 2006;94:642–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suarez AA, Felix AS, Cohn DE. Bokhman Redux: endometrial cancer “types” in the 21st century. Gynecol Oncol. 2017;144:243–9.

Article  PubMed  Google Scholar 

Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE, Heller PB. Surgical pathologic spread patterns of endometrial cancer: a Gynecologic Oncology Group Study. Cancer. 1987;60:2035–41.

Article  CAS  PubMed  Google Scholar 

Slomovitz BM, Burke TW, Eifel PJ, Ramondetta LM, Silva EG, Jhingran A, Oh JC, Atkinson EN, Broaddus RR, Gershenson DM, Lu KH. Uterine papillary serous carcinoma (UPSC): a single institution review of 129 cases. Gynecol Oncol. 2003;91:463–9.

Article  PubMed  Google Scholar 

Saijo M, Nakamura K, Ida N, Nasu A, Yoshino T, Masuyama H, Yanai H. Histologic appearance and immunohistochemistry of DNA mismatch repair protein and p53 in endometrial carcinosarcoma: impact on prognosis and insights into tumorigenesis. Am J Surg Pathol. 2019;43:1493–500.

Article  PubMed  Google Scholar 

Cancer Genome Atlas Research Network. Integrated genomic and molecular characterization of cervical cancer. Nature. 2017;543:378–84.

Article  Google Scholar 

Malik TY, Chishti U, Aziz AB, Sheikh I. Comparison of risk factors and survival of type 1 and type II endometrial cancers. Pak J Med Sci. 2016;32:886–90.

PubMed  PubMed Central  Google Scholar 

Crosbie EJ, Kitson SJ, McAlpine JN, Mukhopadhyay A, Powell ME, Singh N. Endometrial cancer. Lancet. 2022;399:1412–28.

Article  PubMed  Google Scholar 

Ortoft G, Høgdall C, Hansen ES, Dueholm M. Predictive value of the new ESGO-ESTRO-ESP endometrial cancer risk classification on survival and recurrence in the Danish population. Int J Gynecol Cancer. 2021;31:1116–24.

Article  PubMed  Google Scholar 

Kasius JC, Pijnenborg JMA, Lindemann K, Forsse D, van Zwol J, Kristensen GB, Krakstad C, Werner HMJ, Amant F. Risk stratification of endometrial cancer patients: FIGO stage, biomarkers and molecular classification. Cancers. 2021;13:5848.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bussies P, Eta A, Pinto A, George S, Schlumbrecht M. Thrombocytosis as a biomarker in type II, non-endometrioid endometrial cancer. Cancers. 2020;12:2379.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanno M, Yunokawa M, Nakabayashi M, Omi M, Ikki A, Mizusaki M, Nishimura M, Shimizu Y, Okamoto K, Tanaka Y, Fusegi A, Netsu S, Kurita T, et al. Prognosis and adjuvant chemotherapy for patients with positive peritoneal cytology in stage IA endometrial cancer. Sci Rep. 2022;12:166.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sozen H, Çiftçi R, Vatansever D, Topuz S, Iyibozkurt AC, Bozbey HU, Yaşa C, Çali H, Yavuz E, Kucucuk S, Aydiner A, Salihoglu Y. Combination of adjuvant chemotherapy and radiotherapy is associated with improved survival at early stage type II endometrial cancer and carcinosarcoma. Aust N Z J Obstet Gynaecol. 2016;56:199–206.

Article  PubMed  Google Scholar 

Zhang Y, Liu Z, Yu X, Zhang X, Lü S, Chen X, Lü B. The association between metabolic abnormality and endometrial cancer: a large case-control study in China. Gynecol Oncol. 2010;117:41–6.

Article  CAS  PubMed  Google Scholar 

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