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Multi-omic discovery of SCG5 as a shared driver and prognostic biomarker in head-neck and non-small cell lung cancers
Multi-omic discovery of SCG5 as a shared driver and prognostic biomarker in head-neck and non-small cell lung cancers
Patients with head and neck squamous cell carcinoma (HNSC) face a high risk of developing non-small cell lung cancer (NSCL...
Targeting cancer stem cells: advances in small molecules, biologics, and immunotherapies
Targeting cancer stem cells: advances in small molecules, biologics, and immunotherapies
Cancer stem cells are a subpopulation of cancer cells characterized by self-renewal and differentiation potential, as well...
LncRNA HOTAIR down-expression inhibits the invasion and tumorigenicity of epithelial ovarian cancer cells by suppressing TGF-β1 and ZEB1
LncRNA HOTAIR down-expression inhibits the invasion and tumorigenicity of epithelial ovarian cancer cells by suppressing TGF-β1 and ZEB1
Epithelial ovarian cancer (EOC) is a pathological type with a higher mortality rate among gynecological cancers today. Lon...
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
Infection with COVID-19 promotes the progression of pancreatic cancer through the PI3K-AKT signaling pathway
To investigate the effect of COVID-19 infection on pancreatic cancer. Based on the mRNA-Seq data of COVID-19 patients and ...
Increased PAFAH1B3 was associated with poor prognosis and T-cell exhaustion microenvironment in hepatocellular carcinoma
Increased PAFAH1B3 was associated with poor prognosis and T-cell exhaustion microenvironment in hepatocellular carcinoma
The link between T-cell exhaustion (TEX) and PAFAH1B3 in hepatocellular carcinoma (HCC) remains unknown, even though both ...
Treatment outcomes of radiotherapy with concurrent weekly cisplatin in older patients with locally advanced head and neck squamous cell carcinoma
Treatment outcomes of radiotherapy with concurrent weekly cisplatin in older patients with locally advanced head and neck squamous cell carcinoma
Tri-weekly cisplatin and radiotherapy (CDDP + RT) is a standard of care for locally advanced head and neck squ...
Using machine learning-based radiomics to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes
Using machine learning-based radiomics to differentiate between glioma and solitary brain metastasis from lung cancer and its subtypes
To establish a machine learning-based radiomics model to differentiate between glioma and solitary brain metastasis from l...
Deep-learning-based survival prediction of patients with lower limb melanoma
Deep-learning-based survival prediction of patients with lower limb melanoma
For the purpose to examine lower limb melanoma (LLM) and its long-term survival rate, we used data from the Surveillance, ...
Dynamic estimates of survival in oncocytic cell carcinoma of the thyroid
Dynamic estimates of survival in oncocytic cell carcinoma of the thyroid
Little is known about death hazard and conditional survival of oncocytic cell carcinoma of the thyroid (OCC). Patients dia...
Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
Mitophagy genes in ovarian cancer: a comprehensive analysis for improved immunotherapy
Mitophagy is a process of selectively degrading damaged mitochondria, which has been found to be related to immunity, tumo...
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination
Breast cancer stem cells generate immune-suppressive T regulatory cells by secreting TGFβ to evade immune-elimination
Cancer stem cells (CSCs), being the primary contributors in tumor initiation, metastasis, and relapse, ought to have semin...
Clinical application of 192Ir High-Dose-Rate brachytherapy in metastatic lymph nodes of the neck
Clinical application of 192Ir High-Dose-Rate brachytherapy in metastatic lymph nodes of the neck
The objective of this study was to investigate the safety and effectiveness of high-dose-rate brachytherapy as a treatment...
Functional and nonfunctional parathyroid carcinoma: two case reports and literature review
Functional and nonfunctional parathyroid carcinoma: two case reports and literature review
Parathyroid carcinoma (PC) is a rare malignant endocrine tumor. It can be divided into functional and non-functional types...
Pan-cancer analyses of senescence-related genes in extracellular matrix characterization in cancer
Pan-cancer analyses of senescence-related genes in extracellular matrix characterization in cancer
The aged microenvironment plays a crucial role in tumor onset and progression. However, it remains unclear whether and how...
Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments
Effects of HepaSphere microsphere encapsule epirubicin with a new loading method transarterial chemoembolization: in vitro and in vivo experiments
HS microspheres were loaded in a solution of hypertonic saline and contrast medium at different ratios. Morphology, size d...
Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study
Comparison of clinical characteristics and prognosis between type I and type II endometrial cancer: a single-center retrospective study
To explore the differences in clinical characteristics, prognosis, and risk factors between type I and type II endometrial...
Development and validation of a radiomics nomogram for diagnosis of malignant pleural effusion
Development and validation of a radiomics nomogram for diagnosis of malignant pleural effusion
We aimed to develop a radiomics nomogram based on computed tomography (CT) scan features and high-throughput radiomics fea...
Novel diagnostic biomarkers of oxidative stress, immune- infiltration characteristics and experimental validation of SERPINE1 in colon cancer
Novel diagnostic biomarkers of oxidative stress, immune- infiltration characteristics and experimental validation of SERPINE1 in colon cancer
Colon cancer (CC) is a prevalent malignant tumor that affects the colon in the gastrointestinal tract. Its aggressive natu...
Geriatric nutritional risk index as a prognostic marker of first-line immune checkpoint inhibitor combination therapy in patients with renal cell carcinoma: a retrospective multi-center study
Geriatric nutritional risk index as a prognostic marker of first-line immune checkpoint inhibitor combination therapy in patients with renal cell carcinoma: a retrospective multi-center study
This study aimed to investigate the effectiveness of the Geriatric Nutritional Risk Index (GNRI) in predicting the efficac...
A comprehensive prognostic score for head and neck squamous cancer driver genes and phenotype traits
A comprehensive prognostic score for head and neck squamous cancer driver genes and phenotype traits
Head and neck squamous cancer (HNSCC) presents variable phenotype and progression features. Clinically applicable, high-ac...
Posttraumatic growth and illness perception in survivors of adolescent and young adult cancer
Posttraumatic growth and illness perception in survivors of adolescent and young adult cancer
Adolescents and young adults (AYAs) are diagnosed with cancer during a challenging period of life. We aimed to (1) describ...
Down-regulation of DPP4 by TGFβ1/miR29a-3p inhibited proliferation and promoted migration of ovarian cancer cells
Down-regulation of DPP4 by TGFβ1/miR29a-3p inhibited proliferation and promoted migration of ovarian cancer cells
To explore the DPP4 expression changes and functions in ovarian cancer (OV), as well as the regulation mechanism for DDP4....
Molecular pathogenesis, mechanism and therapy of Cav1 in prostate cancer
Molecular pathogenesis, mechanism and therapy of Cav1 in prostate cancer
Prostate cancer is the second incidence of malignant tumors in men worldwide. Its incidence and mortality are increasing y...
Nomogram development and external validation for predicting overall survival and cancer-specific survival in patients with primary retroperitoneal sarcoma: a retrospective cohort study
Nomogram development and external validation for predicting overall survival and cancer-specific survival in patients with primary retroperitoneal sarcoma: a retrospective cohort study
Primary retroperitoneal sarcoma (RPS) comprises over 70 histologic subtypes, yet there are limited studies that have devel...
Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study
Association between testosterone and cancers risk in women: a two-sample Mendelian randomization study
Previous observational studies have explored the correlation between testosterone and cancer risk. However, the causal ass...
The genes regulating sensitivity of tumor cells to T cell-mediated killing: could they be potential personalized immunotherapeutic targets in head and neck squamous cell carcinoma?
The genes regulating sensitivity of tumor cells to T cell-mediated killing: could they be potential personalized immunotherapeutic targets in head and neck squamous cell carcinoma?
To identify the pivotal genes, specifically the STTK genes, that govern the sensitivity of tumor cells to T cell-mediated ...
Prediction and therapeutic targeting of the tumor microenvironment-associated gene CTSK in gastric cancer
Prediction and therapeutic targeting of the tumor microenvironment-associated gene CTSK in gastric cancer
Cathepsin-K (CTSK) is overexpressed in Gastric cancer (GC) and the mechanism of its overexpression in GC is still unclear....
Identification of m6A-associated genes as prognostic and immune-associated biomarkers in Wilms tumor
Identification of m6A-associated genes as prognostic and immune-associated biomarkers in Wilms tumor
Wilms tumor (WT) is a common renal malignant tumor in children. We aimed to investigate the potential prognostic value of ...
Prognostic clinical phenotypes associated with tumor stemness in the immune microenvironment of T-cell exhaustion for hepatocellular carcinoma
Prognostic clinical phenotypes associated with tumor stemness in the immune microenvironment of T-cell exhaustion for hepatocellular carcinoma
T-cell exhaustion (TEX) and high heterogeneity of cancer stem cells (CSCs) are associated with progression, metastasis, an...
A gene signature predicting prognosis of patients with lower-grade gliomas receiving temozolomide therapy
A gene signature predicting prognosis of patients with lower-grade gliomas receiving temozolomide therapy
Temozolomide (TMZ) has been used as a first-line therapy against lower-grade gliomas (LGGs) combined with other chemothera...
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