Arthur LL, Pavlovic-Djuranovic S, Koutmou KS, Green R, Szczesny P, Djuranovic S (2015) Translational control by lysine-encoding A-rich sequences. Sci Adv 1:e1500154

Article  PubMed  PubMed Central  Google Scholar 

Bashir A, Hazari Y, Pal D, Maity D, Bashir S, Singh LR, Shah NN, Fazili KM (2020) Aggregation of M3 (E376D) variant of alpha1- antitrypsin. Sci Rep 10:8290

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cassaignau AME, Cabrita LD, Christodoulou J (2020) How does the ribosome fold the proteome? Annu Rev Biochem 89:389–415

Article  CAS  PubMed  Google Scholar 

Chadani Y, Niwa T, Izumi T, Sugata N, Nagao A, Suzuki T, Chiba S, Ito K, Taguchi H (2017) Intrinsic ribosome destabilization underlies translation and provides an organism with a strategy of environmental sensing. Mol Cell 68:528–539

Article  CAS  PubMed  Google Scholar 

Chandrasekaran V, Juszkiewicz S, Choi J, Puglisi JD, Brown A, Shao S, Ramakrishnan V, Hegde RS (2019) Mechanism of ribosome stalling during translation of a poly(a) tail. Nat Struct Mol Biol 26:1132–1140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deckert A, Cassaignau AME, Wang X, Włodarski T, Chan SHS, Waudby CA, Kirkpatrick JP, Vendruscolo M, Cabrita LD, Christodoulou J (2021) Common sequence motifs of nascent chains engage the ribosome surface and trigger factor. Proc Natl Acad Sci USA 118:e21030151182

Article  Google Scholar 

Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E, Ban N (2004) Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. Nature 431:590–596

Article  CAS  PubMed  Google Scholar 

Ferrari L, Stucchi R, Konstantoulea K, van de Kamp G, Kos R, Geerts WJC, van Bezouwen LS, Förster FG, Altelaar M, Hoogenraad CC, Rüdiger SGD (2020) Arginine π-stacking drives binding to fibrils of the Alzheimer protein tau. Nat Commun 11:571

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujii K, Susanto TT, Saurabh S, Barna M (2018) Decoding the function of expansion segments in ribosomes. Mol Cell 72:1013–1020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gloge F, Becker AH, Kramer G, Bukau B (2014) Co-translational mechanisms of protein maturation. Curr Opin Struct Biol 24:24–33

Article  CAS  PubMed  Google Scholar 

Gomez-Tortosa E, Gallego J, Guerrero-Lopez R, Marcos A, Gil-Neciga E, Sainz MJ, Diaz A, Franco-Macias E, Trujillo-Tiebas MJ, Ayuso C, Perez-Perez J (2013) C9ORF72 hexanucleotide expansions of 20–22 repeats are associated with frontotemporal deterioration. Neurology 80:366–370

Article  CAS  PubMed  Google Scholar 

Gumiero A, Conz C, Gesé GV, Zhang Y, Weyer FA, Lapouge K, Kappes J, von Plehwe U, Schermann G, Fitzke E, Wölfle T, Fischer T, Rospert S, Sinning I (2016) Interaction of the cotranslational Hsp70 Ssb with ribosomal proteins and rRNA depends on its lid domain. Nat Commun 7:13563

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guzman-Luna V, Fuchs AM, Allen AJ, Staikos A, Cavagnero S (2021) An intrinsically disordered nascent protein interacts with specific regions of the ribosomal surface near the exit tunnel. Commun Biol 4:1236

Article  CAS  PubMed  PubMed Central  Google Scholar 

He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S (2022) Insights into the client protein release mechanism of the ATP-independent chaperone spy. Nat Commun 13:2818

Article  CAS  PubMed  PubMed Central  Google Scholar 

He W, Zhang J, Sachsenhauser V, Wang L, Bardwell JCA, Quan S (2020) Increased surface charge in the protein chaperone spy enhances its anti-aggregation activity. J Biol Chem 295:14488–14500

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoffmann A, Bukau B, Kramer G (2020) Structure and function of the molecular chaperone trigger factor. Biochim Biophys Acta (BBA) - Molecular Cell Res 1803:650–661

Article  Google Scholar 

Hughes VA, Meklemburg R, Bottomley SP, Wintrode PL (2014) The Z mutation alters the global structural dynamics of α1-antitrypsin. PLoS One 9:e102617

Article  PubMed  PubMed Central  Google Scholar 

Huntington JA, Carrell RW (2001) The serpins: nature's molecular mousetraps. Sci Prog 84:125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang I, Ahn J-Y (2020) Dysregulation of epigenetic control contributes to schizophrenia-like behavior in Ebp1+/− mice. Int J Mol Sci 21:2609

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hwang I, Kim B-S, Ko HR, Cho S, Lee HY, Cho S-W, Ryu D, Shim S, Ahn J-Y (2022) Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Mol Psychiatry 27:2030–2041

Article  CAS  PubMed  Google Scholar 

Ito Y, Chadani Y, Niwa T, Yamakawa A, Machida K, Imataka H, Taguchi H (2022) Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes. Nat Commun 13:7451

Article  CAS  PubMed  PubMed Central  Google Scholar 

Knight AM, Culviner PH, Kurt-Yilmaz N, Zou T, Ozkan SB, Cavagnero S (2013) Electrostatic effect of the ribosomal surface on nascent polypeptide dynamics. ACS Chem Biol 8:1195–1204

Article  CAS  PubMed  Google Scholar 

Koldewey P, Stull F, Horowitz S, Martin R, Bardwell JCA (2016) Forces driving chaperone action. Cell 166:369–379

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kowalinski E, Bange G, Bradatsch B, Hurt E, Wild K, Sinning I (2007) The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. FEBS Lett 581:4450–4454

Article  CAS  PubMed  Google Scholar 

Kramer G, Shiber A, Bukau B (2019) Mechanisms of Cotranslational maturation of newly synthesized proteins. Annu Rev Biochem 88:337–364

Article  CAS  PubMed  Google Scholar 

Kraushar ML, Krupp F, Harnett D, Turko P, Ambrozkiewicz MC, Sprink T, Selbach M, Spahn CMT (2021) Protein synthesis in the developing neocortex at near-atomic resolution reveals Ebp1-mediated neuronal Proteostasis at the 60S tunnel exit. Mol Cell 81:304–322

Article  CAS  PubMed  Google Scholar 

Kriachkov V, Ormsby AR, Kusnadi EP, McWilliam HEG, Mintern JD, Amarasinghe SL, Ritchie ME, Furic L, Hatters DM (2023) Arginine-rich C9ORF72 ALS proteins stall ribosomes in a manner distinct from a canonical ribosome-associated quality control substrate. J Biol Chem 299:102774

Article  CAS  PubMed  Google Scholar 

Lee C, Kim H, Bardwell JCA (2018) Electrostatic interactions are important for chaperone–client interaction in vivo. Microbiol 164:992–997

Article  CAS  Google Scholar 

Leininger SE, Rodriguez J, Vu QV, Jiang Y, Li MS, Deutsch C, O'Brien EP (2021) Ribosome elongation kinetics of consecutively charged residues are coupled to electrostatic force. Biochemist 60:3223–3235

Article  CAS  Google Scholar 

Li Y, Gu J, Wang C, Hu J, Zhang S, Liu C, Zhang S, Fang Y, Li D (2022) Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation. iScience 25:104356

Article  CAS