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Synaptic Physiology Depends on Electrical Forces and Liquid–Liquid Phase Separation
Synaptic Physiology Depends on Electrical Forces and Liquid–Liquid Phase Separation
Pre- and post-synaptic events are regulated by liquid–liquid phase separation and this phenomenon requires multiple ...
Spatially Regulated Electrical Forces for Biological Catalysis
Spatially Regulated Electrical Forces for Biological Catalysis
It is now well-recognized that biological catalysis depends crucially on spatially regulated electrical forces for optimal...
Making Proteins with Electricity
Making Proteins with Electricity
Ribosomes use multiple electrical forces to regulate new protein construction, to ensure efficient protein cotranslation, ...
Long-Distance Electron Transport in Unicellular Organisms and Biofilms
Long-Distance Electron Transport in Unicellular Organisms and Biofilms
Electrical forces are widespread in single-celled organisms and underpin sophisticated communication systems. Bacterial bi...
Appendix
Appendix
Since the first Chapter dealt with the well-known charge-charge interactions familiar to biologists, this concluding Chapt...
Electrical Forces in Biology Across Distances
Electrical Forces in Biology Across Distances
This first chapter covers essentials needed to understand the multiple roles of electrical forces that impinge on biology,...
Multicellularity and Electrical Forces
Multicellularity and Electrical Forces
Multiple single-celled life forms existed for millennia before some individual cells found ways of gathering together to f...
Crucial Roles of Electricity in Virology
Crucial Roles of Electricity in Virology
Packaging of DNA into viruses in some cases involves remarkably sophisticated electrical control mechanisms. One example i...
Electrical Forces in Lumen Formation
Electrical Forces in Lumen Formation
Epithelial sheets evolved the capacity to fold and reform to create a lumen and therefore new environments. For humans, fo...
Nucleic Acids and Electrical Signals
Nucleic Acids and Electrical Signals
Nucleic acids are highly charged, and electrical forces are involved heavily in how our DNA is compacted and packaged into...
Electrical Forces Regulate Single-Cell Wound Healing
Electrical Forces Regulate Single-Cell Wound Healing
Damage to the cell membrane can be life threatening for single-celled organisms. Several mechanisms of single-cell wound h...
Epigenetic Regulation Via Electrical Forces
Epigenetic Regulation Via Electrical Forces
Multiple epigenetic modulations occur to chromatin rather than to DNA itself and these influence gene expression or gene s...
Electric Forces and ATP Synthesis
Electric Forces and ATP Synthesis
ATP synthase is a rotary motor enzyme that drives the formation of ATP from ADP and P and uses multiple electrical forces ...
Neurological Diseases can be Regulated by Phase Separation
Neurological Diseases can be Regulated by Phase Separation
Several neurological diseases arise from abnormal protein aggregation within neurones and this is closely regulated by pha...
SARS-CoV-2 Is an Electricity-Driven Virus
SARS-CoV-2 Is an Electricity-Driven Virus
One of the most important and challenging biological events of recent times has been the pandemic caused by SARS-CoV-2. Si...
The Link between Oxygen and Basement Membranes
The Link between Oxygen and Basement Membranes
Epithelial tissues and the basement membranes they sit on did not appear for billions of years. Their appearance was delay...
Patterns of Ciliation and Ciliary Signaling in Cancer
Patterns of Ciliation and Ciliary Signaling in Cancer
Among the factors that have been strongly implicated in regulating cancerous transformation, the primary monocilium (ciliu...
Endo-Lysosomal Cation Channels and Infectious Diseases
Endo-Lysosomal Cation Channels and Infectious Diseases
Among the infectious diseases caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi, the most...
Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases
Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases
Neurodegenerative disorders are debilitating and largely untreatable conditions that pose a significant burden to affected...
Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs)
Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs)
Endoplasmic reticulum (ER)-mitochondria regions are specialized subdomains called also mitochondria-associated membranes (...
Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function
Autocrine, Paracrine, and Endocrine Signals That Can Alter Alveolar Macrophages Function
Alveolar macrophages (AMs) are extremely versatile cells with complex functions involved in health or diseases such as pne...
Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders
Role of Oxytocin in Different Neuropsychiatric, Neurodegenerative, and Neurodevelopmental Disorders
Oxytocin has recently gained significant attention because of its role in the pathophysiology and management of dominant n...
The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4
The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4
Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which medi...
Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications
People suffering from obesity and associated metabolic disorders including diabetes are increasing exponentially around th...
Roles of Intramolecular Interactions in the Regulation of TRP Channels
Roles of Intramolecular Interactions in the Regulation of TRP Channels
The transient receptor potential (TRP) channels, classified into six (-A, -V, -P, -C, -M, -ML, -N and -Y) subfamilies, are...
Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer
Novel Therapeutic Approaches of Ion Channels and Transporters in Cancer
The expression and function of many ion channels and transporters in cancer cells display major differences in comparison ...
Ion Transport and Radioresistance
Ion Transport and Radioresistance
Neoplastic transformation is associated with alterations of the ion transports across plasma and intracellular membranes. ...
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research
The intracellular Ca2+ concentration is mainly controlled by Ca2+ channels. These channels form complexes with K+ channels...
Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions
Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions
Members of the solute carrier (SLC) family of transporters are responsible for the cellular influx of a broad range of end...
Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer
Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer
Prostate cancer is the fourth most commonly diagnosed cancer, and although it is often a slow-growing malignancy, it is th...
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