Kadry H, Noorani B, Cucullo L (2020) A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity. Fluids Barriers CNS 17(1):69. https://doi.org/10.1186/s12987-020-00230-3
Article PubMed PubMed Central Google Scholar
Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of the blood-brain barrier. Cell 163(5):1064–1078. https://doi.org/10.1016/j.cell.2015.10.067
Article CAS PubMed PubMed Central Google Scholar
Liddelow SA (2011) Fluids and barriers of the CNS: a historical viewpoint. Fluids Barriers CNS 8(1):2. https://doi.org/10.1186/2045-8118-8-2
Article CAS PubMed PubMed Central Google Scholar
Ridley H (1987) The anatomy of the brain. Classics of Neurology & Neurosurgery
Thakur JD, Sonig A, Chittiboina P, Khan IS, Wadhwa R, Nanda A (2012) Humphrey Ridley (1653–1708): 17th century evolution in neuroanatomy and selective cerebrovascular injections for cadaver dissection. Neurosurg Focus 33(2):E3. https://doi.org/10.3171/2012.6.FOCUS12139
Nilles KL, Williams EI, Betterton RD, Davis TP, Ronaldson PT (2022) Blood-brain barrier transporters: opportunities for therapeutic development in ischemic stroke. Int J Mol Sci 23(3):1898. https://doi.org/10.3390/ijms23031898
Article CAS PubMed PubMed Central Google Scholar
Ronaldson PT, Davis TP (2022) Transport mechanisms at the blood-brain barrier and in cellular compartments of the neurovascular unit: focus on CNS delivery of small molecule drugs. Pharmaceutics 14(7):1501. https://doi.org/10.3390/pharmaceutics14071501
Article CAS PubMed PubMed Central Google Scholar
Kanai Y, Segawa H, Miyamoto KI, Uchino H, Takeda E, Endou H (1998) Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98). J Biol Chem 273(36):23629–23632
Article CAS PubMed Google Scholar
Mastroberardino L, Spindler B, Pfeiffer R et al (1998) Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395(6699):288–291
Article CAS PubMed Google Scholar
Prasad PD, Wang H, Huang W et al (1999) Human LAT1, a subunit of system L amino acid transporter: molecular cloning and transport function. Biochem Biophys Res Commun 255(2):283–288
Article CAS PubMed Google Scholar
Kantipudi S, Jeckelmann JM, Ucurum Z, Bosshart PD, Fotiadis D (2020) The heavy chain 4F2hc modulates the substrate affinity and specificity of the light chains LAT1 and LAT2. Int J Mol Sci 21(20):7573. https://doi.org/10.3390/ijms21207573
Article CAS PubMed PubMed Central Google Scholar
Chiduza GN, Johnson RM, Wright GSA, Antonyuk SV, Muench SP, Hasnain SS (2019) LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM. Acta Crystallogr D Struct Biol 75(Pt 7):660–669. https://doi.org/10.1107/S2059798319009094
Article CAS PubMed PubMed Central Google Scholar
Napolitano L, Scalise M, Galluccio M, Pochini L, Albanese LM, Indiveri C (2015) LAT1 is the transport competent unit of the LAT1/CD98 heterodimeric amino acid transporter. Int J Biochem Cell Biol 67:25–33. https://doi.org/10.1016/j.biocel.2015.08.004
Article CAS PubMed Google Scholar
Campbell WA, Thompson NL (2001) Overexpression of LAT1/CD98 light chain is sufficient to increase system L-amino acid transport activity in mouse hepatocytes but not fibroblasts. J Biol Chem 276(20):16877–16884. https://doi.org/10.1074/jbc.M008248200
Article CAS PubMed Google Scholar
Boado RJ, Li JY, Chu C, Ogoshi F, Wise P, Pardridge WM (2005) Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1. Biochim Biophys Acta 1715(2):104–110. https://doi.org/10.1016/j.bbamem.2005.07.007
Article CAS PubMed Google Scholar
Pfeiffer R, Spindler B, Loffing J, Skelly PJ, Shoemaker CB, Verrey F (1998) Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond. FEBS Lett 439(1–2):157–162. https://doi.org/10.1016/s0014-5793(98)01359-3
Article CAS PubMed Google Scholar
Kantipudi S, Jeckelmann JM, Ucurum Z, Bosshart PD, Fotiadis D (2020) The heavy chain 4F2hc modulates the substrate affinity and specificity of the light chains LAT1 and LAT2. Int J Mol Sci. 21(20):7573. https://doi.org/10.3390/ijms21207573
Article CAS PubMed PubMed Central Google Scholar
Papin-Michault C, Bonnetaud C, Dufour M et al (2016) Study of LAT1 expression in brain metastases: towards a better understanding of the results of positron emission tomography using amino acid tracers. PLoS ONE 11(6):e0157139. https://doi.org/10.1371/journal.pone.0157139
Article CAS PubMed PubMed Central Google Scholar
Yan R, Li Y, Müller J et al (2021) Mechanism of substrate transport and inhibition of the human LAT1-4F2hc amino acid transporter. Cell Discov 7(1):16. https://doi.org/10.1038/s41421-021-00247-4
Article CAS PubMed PubMed Central Google Scholar
Ozgür B, Puris E, Brachner A et al (2023) Characterization of an iPSC-based barrier model for blood-brain barrier investigations using the SBAD0201 stem cell line. Fluids Barriers CNS 20(1):96. https://doi.org/10.1186/s12987-023-00501-9
Article CAS PubMed PubMed Central Google Scholar
Kurosawa T, Sako D, Tega Y et al (2022) Construction and functional evaluation of a three-dimensional blood-brain barrier model equipped with human induced pluripotent stem cell-derived brain microvascular endothelial cells. Pharm Res 39(7):1535–1547. https://doi.org/10.1007/s11095-022-03249-3
Article CAS PubMed PubMed Central Google Scholar
Ruck T, Bittner S, Epping L, Herrmann AM, Meuth SG (2014) Isolation of primary murine brain microvascular endothelial cells. J Vis Exp 93:e52204. https://doi.org/10.3791/52204
Silwedel C, Förster C (2006) Differential susceptibility of cerebral and cerebellar murine brain microvascular endothelial cells to loss of barrier properties in response to inflammatory stimuli. J Neuroimmunol 179(1–2):37–45. https://doi.org/10.1016/j.jneuroim.2006.06.019
Article CAS PubMed Google Scholar
Abbott NJ, Dolman DE, Drndarski S, Fredriksson SM (2012) An improved in vitro blood-brain barrier model: rat brain endothelial cells co-cultured with astrocytes. Methods Mol Biol 814:415–430. https://doi.org/10.1007/978-1-61779-452-0_28
Article CAS PubMed Google Scholar
Gaillard PJ, Voorwinden LH, Nielsen JL et al (2001) Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. Eur J Pharm Sci 12(3):215–222. https://doi.org/10.1016/s0928-0987(00)00123-8
Article CAS PubMed Google Scholar
Hayashi K, Nakao S, Nakaoke R, Nakagawa S, Kitagawa N, Niwa M (2004) Effects of hypoxia on endothelial/pericytic co-culture model of the blood-brain barrier. Regul Pept 123(1–3):77–83. https://doi.org/10.1016/j.regpep.2004.05.023
Article CAS PubMed Google Scholar
Thomsen LB, Burkhart A, Moos T (2015) A Triple culture model of the blood-brain barrier using porcine brain endothelial cells, astrocytes and pericytes. PLoS ONE 10(8):e0134765. https://doi.org/10.1371/journal.pone.0134765
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