Spatial Changes in Hippocampal Transcriptomic Profiles Following Limbic Non-convulsive Status Epilepticus: Insights into Long-Term Inflammation and Cognitive Deficits

Smith DM, McGinnis EL, Walleigh DJ, Abend NS (2016) Management of status epilepticus in children. J Clin Med. https://doi.org/10.3390/jcm5040047

Article  PubMed  PubMed Central  Google Scholar 

Maganti R, Gerber P, Drees C, Chung S (2008) Nonconvulsive status epilepticus. Epilepsy Behav 12(4):572–586. https://doi.org/10.1016/j.yebeh.2007.12.002

Article  PubMed  Google Scholar 

Sutter R, Ruegg S, Kaplan PW (2012) Epidemiology, diagnosis, and management of nonconvulsive status epilepticus: opening Pandora’s box. Neurol Clin Pract 2(4):275–286. https://doi.org/10.1212/CPJ.0b013e318278be75

Article  PubMed  PubMed Central  Google Scholar 

Jaafar F, Abboud MR, Obeid M (2022). Causes of New-Onset Seizures and Their Treatment in Children With Non-CNS Malignancies: A Retrospective Study in a Tertiary Care Center. Pediatr Neurol, 137, 17-21. https://doi.org/10.1016/j.pediatrneurol.2022.08.013

Holtkamp M, Meierkord H (2011) Nonconvulsive status epilepticus: a diagnostic and therapeutic challenge in the intensive care setting. Ther Adv Neurol Disord 4(3):169–181

Article  PubMed  PubMed Central  Google Scholar 

Kaplan PW (2002) Behavioral manifestations of nonconvulsive status epilepticus. Epilepsy Behav 3(2):122–139. https://doi.org/10.1006/ebeh.2002.0336

Article  PubMed  Google Scholar 

Husain A, Horn G, Jacobson M (2003) Non-convulsive status epilepticus: usefulness of clinical features in selecting patients for urgent EEG. J Neurol Neurosurg Psychiatry 74(2):189

Article  CAS  PubMed  PubMed Central  Google Scholar 

Koul R (2000) Non-convulsive status epilepticus in children. A report of 12 cases. Neurosci J 5(1):13–17

Roodsari GS, Chari G, Mera B, Zehtabchi S (2017) Can patients with non-convulsive seizure be identified in the emergency department? World J Emerg Med 8(3):190

Article  PubMed  PubMed Central  Google Scholar 

Drislane FW (2000) Presentation, evaluation, and treatment of nonconvulsive status epilepticus. Epilepsy Behav 1(5):301–314. https://doi.org/10.1006/ebeh.2000.0100

Article  CAS  PubMed  Google Scholar 

Mrad Y, El Jammal R, Hajjar H, Alturk S, Salah H, Chehade HD, Dandash F, Mallah Z et al (2023) Lestaurtinib (CEP-701) reduces the duration of limbic status epilepticus in periadolescent rats. Epilepsy Res 195:107198. https://doi.org/10.1016/j.eplepsyres.2023.107198

Article  CAS  PubMed  Google Scholar 

Obeid M, Frank J, Medina M, Finckbone V, Bliss R, Bista B, Majmudar S, Hurst D et al (2010) Neuroprotective effects of leptin following kainic acid-induced status epilepticus. Epilepsy Behav 19(3):278–283. https://doi.org/10.1016/j.yebeh.2010.07.023

Article  PubMed  Google Scholar 

Medlej Y, Salah H, Wadi L, Saad S, Asdikian R, Karnib N, Ghazal D, Bashir B, et al. (2019) Overview on emotional behavioral testing in rodent models of pediatric epilepsy. Methods Mol Biol 2011:345–367. https://doi.org/10.1007/978-1-4939-9554-7_20

Article  CAS  PubMed  Google Scholar 

Trinka E, Cock H, Hesdorffer D, Rossetti AO, Scheffer IE, Shinnar S, Shorvon S, Lowenstein DH (2015) A definition and classification of status epilepticus–report of the ILAE task force on classification of status epilepticus. Epilepsia 56(10):1515–1523. https://doi.org/10.1111/epi.13121

Article  PubMed  Google Scholar 

Trinka E, Kälviäinen R (2017) 25 years of advances in the definition, classification and treatment of status epilepticus. Seizure 44:65–73. https://doi.org/10.1016/j.seizure.2016.11.001

Article  PubMed  Google Scholar 

Rossetti AO, Hirsch LJ, Drislane FW (2019) Nonconvulsive seizures and nonconvulsive status epilepticus in the neuro ICU should or should not be treated aggressively: a debate. Clin Neurophysiol Pract 4:170–177

Article  PubMed  PubMed Central  Google Scholar 

Tay SK, Hirsch LJ, Leary L, Jette N, Wittman J, Akman CI (2006) Nonconvulsive status epilepticus in children: clinical and EEG characteristics. Epilepsia 47(9):1504–1509. https://doi.org/10.1111/j.1528-1167.2006.00623.x

Article  PubMed  Google Scholar 

Marchi NA, Novy J, Faouzi M, Stähli C, Burnand B, Rossetti AO (2015) Status epilepticus: impact of therapeutic coma on outcome. Crit Care Med 43(5):1003–1009

Article  PubMed  Google Scholar 

Kaplan PW (1999) Assessing the outcomes in patients with nonconvulsive status epilepticus: nonconvulsive status epilepticus is underdiagnosed, potentially overtreated, and confounded by comorbidity. J Clin Neurophysiol 16(4):341–352

Article  CAS  PubMed  Google Scholar 

Engel J Jr, Ludwig BI, Fetell M (1978) Prolonged partial complex status epilepticus: EEG and behavioral observations. Neurology 28(9):863–863

Krumholz A, Sung G, Fisher R, Barry E, Bergey G, Grattan L (1995) Complex partial status epilepticus accompanied by serious morbidity and mortality. Neurology 45(8):1499–1504

Article  CAS  PubMed  Google Scholar 

Asdikian R, Hajjar H, Alturk S, Asdikian JP, Jaafar F, Salah H, Mrad Y, Issa F et al (2021) Hippocampal injury and learning deficits following non-convulsive status epilepticus in periadolescent rats. Epilepsy Behav 125:108415. https://doi.org/10.1016/j.yebeh.2021.108415

Article  PubMed  Google Scholar 

El Jammal R, Tfaily A, Cochran AG, Nguyen T, Miller D, El Ayoubi N, Soluoku T, White FA et al (2024) The long-term effects of limbic non-convulsive status epilepticus in peri-adolescent rats. Epilepsy Behav 161:110086. https://doi.org/10.1016/j.yebeh.2024.110086

Article  PubMed  Google Scholar 

Vespa P, McArthur D, Xu Y, Eliseo M, Etchepare M, Dinov I, Alger J, Glenn T, et al. (2010) Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy. Neurology 75(9):792–798

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greiner HM, Holland K, Leach JL, Horn PS, Hershey AD, Rose DF (2012) Nonconvulsive status epilepticus: the encephalopathic pediatric patient. Pediatrics 129(3):e748–e755

Article  PubMed  Google Scholar 

Jalloul D, Hajjar H, Asdikian R, Maawie M, Nasrallah L, Medlej Y, Darwich M, Karnib N et al (2021) Potentiating hemorrhage in a periadolescent rat model of closed-head traumatic brain injury worsens hyperexcitability but not behavioral deficits. Int J Mol Sci. https://doi.org/10.3390/ijms22126456

Article  PubMed  PubMed Central  Google Scholar 

Danaher P, Kim Y, Nelson B, Griswold M, Yang Z, Piazza E, Beechem JM (2022) Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data. Nat Commun 13(1):385. https://doi.org/10.1038/s41467-022-28020-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rendtorff ND, Lodahl M, Boulahbel H, Johansen IR, Pandya A, Welch KO, Norris VW, Arnos KS et al (2011) Identification of p.A684V missense mutation in the WFS1 gene as a frequent cause of autosomal dominant optic atrophy and hearing impairment. Am J Med Genet A. https://doi.org/10.1002/ajmg.a.33970

Article  PubMed  PubMed Central  Google Scholar 

Hallmann K, Kudin AP, Zsurka G, Kornblum C, Reimann J, Stuve B, Waltz S, Hattingen E et al (2016) Loss of the smallest subunit of cytochrome c oxidase, COX8A, causes Leigh-like syndrome and epilepsy. Brain 139(2):338–345. https://doi.org/10.1093/brain/awv357

Article  PubMed  Google Scholar 

Stolz JR, Foote KM, Veenstra-Knol HE, Pfundt R, Ten Broeke SW, de Leeuw N, Roht L, Pajusalu S et al (2021) Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders. Am J Hum Genet 108(9):1692–1709. https://doi.org/10.1016/j.ajhg.2021.07.007

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cordoba M, Rodriguez S, Gonzalez Moron D, Medina N, Kauffman MA (2015) Expanding the spectrum of Grik2 mutations: intellectual disability, behavioural disorder, epilepsy and dystonia. Clin Genet 87(3):293–295. https://doi.org/10.1111/cge.12423

Article  CAS  PubMed  Google Scholar 

Johannesen KM, Gardella E, Gjerulfsen CE, Bayat A, Rouhl RPW, Reijnders M, Whalen S, Keren B, et al. (2021) PURA-related developmental and epileptic encephalopathy: phenotypic and genotypic spectrum. Neurol Genet 7(6):e613.

Comments (0)

No login
gif