Finnerup NB, Kuner R, Jensen TS (2021) Neuropathic pain: from mechanisms to treatment. Physiol Rev 101(1):259–301. https://doi.org/10.1152/physrev.00045.2019

Article  CAS  PubMed  Google Scholar 

Schmid AB, Tampin B, Baron R, Finnerup NB, Hansson P, Hietaharju A, Konstantinou K, Lin CWC et al (2023) Recommendations for terminology and the identification of neuropathic pain in people with spine-related leg pain. Outcomes from the NeuPSIG working group. Pain 164(8):1693–1704. https://doi.org/10.1097/j.pain.0000000000002919

Article  PubMed  PubMed Central  Google Scholar 

Smith BH, Hebert HL, Veluchamy A (2020) Neuropathic pain in the community: prevalence, impact, and risk factors. Pain 161(Suppl 1):S127–S137. https://doi.org/10.1097/j.pain.0000000000001824

Article  PubMed  Google Scholar 

Attal N, Bouhassira D, Colvin L (2023) Advances and challenges in neuropathic pain: a narrative review and future directions. Br J Anaesth 131(1):79–92. https://doi.org/10.1016/j.bja.2023.04.021

Article  PubMed  Google Scholar 

Vieira WF, Coelho DRA, Litwiler ST, McEachern KM, Clancy JA, Morales-Quezada L, Cassano P (2024) Neuropathic pain, mood, and stress-related disorders: a literature review of comorbidity and co-pathogenesis. Neurosci Biobehav Rev 161:105673. https://doi.org/10.1016/j.neubiorev.2024.105673

Article  CAS  PubMed  Google Scholar 

Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A et al (2017) Neuropathic pain Nat Rev Dis Primers 3:17002. https://doi.org/10.1038/nrdp.2017.2

Article  PubMed  Google Scholar 

Gotoh M, Miyamoto Y, Ikeshima-Kataoka H (2023) Astrocytic neuroimmunological roles interacting with microglial cells in neurodegenerative diseases. Int J Mol Sci 24(2):. https://doi.org/10.3390/ijms24021599

Schulte A, Lohner H, Degenbeck J, Segebarth D, Rittner HL, Blum R, Aue A (2023) Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity. Pain 164(4):728–740. https://doi.org/10.1097/j.pain.0000000000002758

Article  CAS  PubMed  Google Scholar 

Kong ER, Li YC, Deng MQ, Hua T, Yang M, Li J, Feng XD, Yuan HB (2022) Glycometabolism reprogramming of glial cells in central nervous system: novel target for neuropathic pain. Front Immunol 13:. https://doi.org/10.3389/fimmu.2022.861290

Butovsky O, Weiner HL (2018) Microglial signatures and their role in health and disease. Nat Rev Neurosci 19(10):622–635. https://doi.org/10.1038/s41583-018-0057-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muller CE, Claff T (2022) Activated microglia nibbling glycosaminoglycans from spinal cord perineural nets: a new mechanism for neuropathic pain. Signal Transduct Target Ther 7(1):333. https://doi.org/10.1038/s41392-022-01162-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi MH, Liu YU, Liu K, Chen TJ, Bosco DB, Zheng JY, Xie ML, Zhou LJ et al (2021) Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice. Brain Behav Immun 92:78–89. https://doi.org/10.1016/j.bbi.2020.11.030

Article  CAS  PubMed  Google Scholar 

Ghazisaeidi S, Muley MM, Salter MW (2023) Neuropathic pain: mechanisms, sex differences, and potential therapies for a global problem. Annu Rev Pharmacol Toxicol 63:565–583. https://doi.org/10.1146/annurev-pharmtox-051421-112259

Article  CAS  PubMed  Google Scholar 

Cavalli E, Mammana S, Nicoletti F, Bramanti P, Mazzon E (2019) The neuropathic pain: an overview of the current treatment and future therapeutic approaches. Int J Immunopathol Pharmacol 33:. https://doi.org/10.1177/2058738419838383

Attal N (2019) Pharmacological treatments of neuropathic pain: the latest recommendations. Rev Neurol (Paris) 175(1–2):46–50. https://doi.org/10.1016/j.neurol.2018.08.005

Article  CAS  PubMed  Google Scholar 

Baron R, Dickenson AH, Calvo M, Dib-Hajj SD, Bennett DL (2023) Maximizing treatment efficacy through patient stratification in neuropathic pain trials. Nat Rev Neurol 19(1):53–64. https://doi.org/10.1038/s41582-022-00741-7

Article  CAS  PubMed  Google Scholar 

Derry S, Bell RF, Straube S, Wiffen PJ, Aldington D, Moore RA (2019) Pregabalin for neuropathic pain in adults. Cochrane Database Syst Rev 1(1):Cd007076. https://doi.org/10.1002/14651858.CD007076.pub3

Article  PubMed  Google Scholar 

Thouaye M, Yalcin I (2023) Neuropathic pain: from actual pharmacological treatments to new therapeutic horizons. Pharmacol Ther 251:108546. https://doi.org/10.1016/j.pharmthera.2023.108546

Article  CAS  PubMed  Google Scholar 

Knotkova H, Hamani C, Sivanesan E, Le Beuffe MFE, Moon JY, Cohen SP, Huntoon MA (2021) Neuromodulation for chronic pain. Lancet 397(10289):2111–2124. https://doi.org/10.1016/S0140-6736(21)00794-7

Article  PubMed  Google Scholar 

Che X, Cash RFH, Luo X, Luo H, Lu X, Xu F, Zang YF, Fitzgerald PB et al (2021) High-frequency rTMS over the dorsolateral prefrontal cortex on chronic and provoked pain: a systematic review and meta-analysis. Brain Stimul 14(5):1135–1146. https://doi.org/10.1016/j.brs.2021.07.004

Article  PubMed  Google Scholar 

O’Connell NE, Ferraro MC, Gibson W, Rice AS, Vase L, Coyle D, Eccleston C (2021) Implanted spinal neuromodulation interventions for chronic pain in adults. Cochrane Database Syst Rev 12(12):Cd013756. https://doi.org/10.1002/14651858.CD013756.pub2

Article  PubMed  Google Scholar 

Kong Q, Li T, Reddy S, Hodges S, Kong J (2024) Brain stimulation targets for chronic pain: insights from meta-analysis, functional connectivity and literature review. Neurotherapeutics 21(1):e00297. https://doi.org/10.1016/j.neurot.2023.10.007

Article  PubMed  Google Scholar 

Yan H, Shlobin NA, Jung Y, Zhang KK, Warsi N, Kulkarni AV, Ibrahim GM (2023) Nucleus accumbens: a systematic review of neural circuitry and clinical studies in healthy and pathological states. J Neurosurg 138(2):337–346. https://doi.org/10.3171/2022.5.Jns212548

Article  PubMed  Google Scholar 

Sumizono M, Yoshizato Y, Yamamoto R, Imai T, Tani A, Nakanishi K, Nakakogawa T, Matsuoka T et al (2022) Mechanisms of neuropathic pain and pain-relieving effects of exercise therapy in a rat neuropathic pain model. J Pain Res 15:1925–1938. https://doi.org/10.2147/JPR.S367818

Article  PubMed  PubMed Central  Google Scholar 

Hattori T, Shimo K, Niwa Y, Katsura Y, Tokiwa Y, Ohga S, Matsubara T (2022) Pain sensitization and neuropathic pain-like symptoms associated with effectiveness of exercise therapy in patients with hip and knee osteoarthritis. Pain Res Manag 2022:4323045. https://doi.org/10.1155/2022/4323045

Article  PubMed  PubMed Central  Google Scholar 

Dugan EA, Schachner B, Jergova S, Sagen J (2021) Intensive locomotor training provides sustained alleviation of chronic spinal cord injury-associated neuropathic pain: a two-year pre-clinical study. J Neurotrauma 38(6):789–802. https://doi.org/10.1089/neu.2020.7378

Article  PubMed  Google Scholar 

Matesanz-Garcia L, Billerot C, Fundaun J, Schmid AB (2023) Effect of type and dose of exercise on neuropathic pain systematic review and meta-analysis. J Pain 24(6):921-938. https://doi.org/10.1016/j.jpain.2023.01.011

Leitzelar BN, Koltyn KF (2021) Exercise and neuropathic pain: a general overview of preclinical and clinical research. Sports Medicine-Open 7(1):. https://doi.org/10.1186/s40798-021-00307-9

Landmark T, Romundstad P, Borchgrevink PC, Kaasa S, Dale O (2011) Associations between recreational exercise and chronic pain in the general population: evidence from the HUNT 3 study. Pain 152(10):2241–2247. https://doi.org/10.1016/j.pain.2011.04.029

Article  PubMed  Google Scholar 

Sun X, Wang C, Wu J, Chen X, He H (2022) Effect of TGF-beta1-mediated exercise analgesia in spared nerve injury mice. Neural Plast 2022:7382327. https://doi.org/10.1155/2022/7382327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng X, Yu Z, Hu W, Chen J, Chen W, Wang L, Li X, Zhang W et al (2022) Voluntary exercise ameliorates neuropathic pain by suppressing calcitonin gene-related peptide and ionized calcium-binding adapter molecule 1 overexpression in the lumbar dorsal horns in response to injury to the cervical spinal cord. Exp Neurol 354:114105. https://doi.org/10.1016/j.expneurol.2022.114105

Article  CAS  PubMed  Google Scholar 

Bai J, Geng B, Wang X, Wang S, Yi Q, Tang Y, Xia Y (2022) Exercise facilitates the M1-to-M2 polarization of microglia by enhancing autophagy via the BDNF/AKT/mTOR pathway in neuropathic pain. Pain Physician 25(7):E1137–E1151. https://www.ncbi.nlm.nih.gov/pubmed/36288601

Smith CJ (2023) Evolutionarily conserved concepts in glial cell biology. Curr Opin Neurobiol 78:. https://doi.org/10.1016/j.conb.2022.102669