The translocation of ions across the cellular membrane is essential for adequate regulation of different physiological processes [1, 2, 3, 4, 5]. Nature has endowed organisms with structurally complex transmembrane ion transporters to facilitate the requisite transport of ions and substantial biomolecules in accordance with cellular demands in response to external stimuli [6]. Drawing inspiration from natural systems, the scientific community has focused on the functionalization of proteins, wherein the structure and functionality of these proteins can be adjusted through various external stimuli [7,8]. Therefore, using different stimuli in the synthetic ion transport systems can provide control over the transmembrane transport of the ions. In the contemporary landscape of stimuli-responsive systems, factors such as pH, redox potential, light, ligands, and enzymes are prominently featured. In this review, we summarized diverse strategies employed in the advancement of stimuli-responsive ion transport systems over the past two years (See Figure 1, Figure 2, Figure 3, Figure 4).