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Mass spectrometry-based characterization of histone post-translational modification
In eukaryotes, the fundamental unit of chromatin is nucleosome, which contains approximately 147 base pairs of DNA wrapped...
Evolving advances of proximity labeling in capturing biomolecular interactions
Proximity labeling (PL) has emerged as a powerful technology to capture biomolecular interactions in living systems, gaini...
In vivo cross-linking mass spectrometry: Advances and challenges in decoding protein conformational dynamics and complex regulatory networks in living cells
The dynamic conformations of intracellular proteins and their interaction networks constitute the structural foundation of...
Emerging trends in chemoproteomics: Mapping the landscape of protein–metabolite interactions
Metabolites, long recognized as essential reactants and products of cellular metabolism—serving as energy carriers, struct...
Optogenetic engineering for ion channel modulation
The field of optogenetics traces its roots to the discovery of bacteriorhodopsin (BR) from Halobacterium salinarum in 1971...
Lipid probes to study ion channels
Over 1000 different lipid species are found in eucaryotic cells with 5 % of our genes solely used for their synthesis [1]....
Stimuli-responsive synthetic ionophores for therapeutic applications
The translocation of ions across the cellular membrane is essential for adequate regulation of different physiological pro...
Illuminating antifungal mode of action and resistance with fluorescent probes
The rise in fungal infections, driven by pathogens resistant to the limited scope of antifungal agents available, poses an...
Recent advances in high-throughput screening methods for small molecule modulators in bacteria
It is estimated that antibiotic-resistant (ABR) infections directly caused 1.27 million deaths and contributed to a furthe...
Corrigendum to “Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling” Curr Opin Chem Biol 84 (2025) 102564
Volume 85, April 2025, 102583Author links open overlay panelAnokhi Shah 1 2, Joshua L. Wort 1 2, Yue Ma 1 2, Christos Plio...
Redirecting the host immune response to bacterial infection with antibody-recruiting molecules (ARMs)
Bacterial infections are an increasing global health concern, driven by the dual threat of antibiotic resistance and bacte...
Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes
Catalytic drugs may be envisioned as a future holy grail in medical therapy offering low-dose therapy and selectivity base...
Recent advances in de novo designed metallopeptides as tailored enzyme mimics
It is widely hypothesized that simple organic molecules that polymerized into peptides formed the foundation for early bio...
Corrigendum to “Bacterial diterpene synthases: New opportunities for mechanistic enzymology and engineered biosynthesis” [Curr Opin Chem Biol, 16 (2012) 132–141
Volume 86, June 2025, 102594Author links open overlay panelMichael J. Smanski 1, Ryan M. Peterson 2 3, Sheng-Xiong Huang 3...
Small-molecule tools for YEATS domain proteins
Small-molecule tools for YEATS domain proteins
Transcriptional co-regulatory proteins act on and through chromatin to control RNA polymerase activity [1]. These proteins...
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm
Post-translational modifications (PTMs) of proteins, such as methylation, phosphorylation, and glycosylation, have a profo...
Editorial overview: Glycobiology (2023)
Editorial overview: Glycobiology (2023)
Matthew Macauley is an associate professor within the Department of Chemistry at the University of Alberta and currently h...
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Enzymes mediate a great diversity of reactions that enable a wide range of cellular processes. The activities of enzymes w...
Nutritional metabolomics: Recent developments and future needs
Nutritional metabolomics: Recent developments and future needs
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Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epide...
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-translational modification known as ADP-rib...
Global approaches for protein thiol redox state detection
Global approaches for protein thiol redox state detection
Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence, cysteine often has important ...
Editorial overview: Imaging metal ions in biological systems
Editorial overview: Imaging metal ions in biological systems
Daniela Buccella. Dr. Buccella is a professor in the Department of Chemistry at New York University. She obtained her bach...
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation
Within the past decade, the role of cysteine oxidation in organismal stress response has been established as a fundamental...
Recent chemical synthesis of plant polysaccharides
Recent chemical synthesis of plant polysaccharides
As the essential and most abundant biomolecules, carbohydrates are involved in the numerous biological processes with a va...
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Cong Liu received his Ph.D. in Biochemistry from the Peking University, followed by a postdoc training at UCLA. He started...
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Zinc (Zn2+) is an important component of various proteins and plays important roles in many biological processes. It is bu...
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
Curative oncologic surgery successfully removes all cancerous tissues from the body and is the most effective treatment mo...
Virus-assisted directed evolution of biomolecules
Billions of years of natural evolution has created an astounding variety of biomolecules with diverse structures and funct...
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level
Proteins and nucleic acids undergo countless encounters in the cell. While some interactions exhibit well-defined stoichio...
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