Effect of cannabinoids on the efficacy and side effects of anticancer therapeutic strategies – Current status of preclinical and clinical research

2-AG

2-arachidonylglycerol

ABC

adenosine triphosphate-binding cassette

ACEA

arachidonyl-2′-chloroethylamide

ACPA

arachidonoylcyclopropamide

AEA

N-arachidonoylethanolamine

AMPK

adenosine monophosphate-activated kinase

ATF4

activating transcription factor 4

Atg1

protein kinase autophagy related 1

ATM kinase

ataxia-telangiectasia mutated kinase

β5i

β immunoproteasome catalytic β5i subunit

Bax

B-cell lymphoma 2-associated X protein

BCAS1

breast carcinoma amplified sequence 1

BCRP, ABCG2

breast cancer resistant protein

bFGF

basic fibroblast growth factor

BNIP3

B-cell lymphoma 2 interacting protein 3

BRAF

v-raf murine sarcoma viral oncogene homolog B

CaMKKβ

calmodulin-activated kinase kinase β

CB receptor

cannabinoid receptor

CB1

cannabinoid receptor type 1

CB2

cannabinoid receptor type 2

CCT7

chaperonin containing TCP1, subunit 7 (Eta)

CD147

cluster of differentiation 147 or extracellular matrix metalloproteinase inducer (EMMPRIN)

CDK

cyclin-dependent kinase

CDKN2A

cyclin-dependent kinase inhibitor 2A

CAR-T cells

chimeric antigen receptor T cells

cGAS-STING

cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes

CINV

chemotherapy-induced nausea and vomiting

CIPN

chemotherapy-induced peripheral neuropathy

COX8

cytochrome C oxidase subunit VIII

CTLA4

cytotoxic T-lymphocyte-associated protein 4

CXCR4

C-X-C chemokine receptor 4

DDIT3

DNA damage inducible transcript 3

DHEA

N-docosahexaenoylethanolamide

DNAJC11

DnaJ heat shock protein family (Hsp40) member C11

E2F1

E2F transcription factor 1

EGF

epidermal growth factor

EGR3

early growth response 3

eIF2α

eukaryotic translation initiation factor 2α

EMA

European Medicines Agency

EMT

epithelial-to-mesenchymal transition

EPEA

N-eicosapentaenoylethanolamine

ERK

extracellular signal-regulated kinase

FAAH

fatty acid amide hydrolase

FABP5

fatty acid-binding protein 5

FADS2

fatty acyl desaturase 2 (FADS2)

FDA

U.S. Food and Drug Administration

GPR

G protein-coupled receptor

GPX4

glutathione peroxidase 4

HER2

human epidermal growth factor receptor-2

HIF

hypoxia-inducible factor

HNSCC

head and neck squamous cell carcinoma

JNK

c-Jun N-terminal kinase

LC3

microtubule-associated protein 1A/1B-Light Chain 3

LEA

linoleoyl ethanolamide

MAGL

monoacylglycerol lipase

MAP3K4

mitogen-activated protein kinase kinase kinase 4

MAPK

mitogen-activated protein kinase

MEK

mitogen-activated protein kinase kinase

MGMT

methylguanine methyltransferase

MMP-13

matrix metalloproteinase-13

mPTP

mitochondrial permeability transition pore

MRP1

multidrug resistance-associated protein 1, ABCC1

mTOR

mammalian target of rapamycin

NADP

nicotinamide adenine dinucleotide phosphate

NDUFA2

NADH:ubiquinone oxidoreductase subunit A2

NRF-2

nuclear factor erythroid 2-related factor 2

NSCLC

non-small cell lung cancer

p21

cyclin-dependent kinase inhibitor 1

p27Kip1

cyclin-dependent kinase inhibitor 1B

PARP

poly(ADP-ribose) polymerase

PDGF

platelet-derived growth factor

PD-L1

programmed death ligand 1

PEA

N-palmitoylethanolamine

PI3K

phosphatidylinositol-3-kinase

P-gp

P-glycoprotein, ABCB1

PINK1

phosphatase and tensin homolog-induced kinase 1

PPAR

peroxisome proliferator-activated receptor

PSA

prostate specific antigen

PTEN

phosphatase and tensin homolog

RANK

receptor activator of nuclear factor-κB

ROS

reactive oxygen species

RSL3

ras-selective lethal small protein 3

SCD1

stearoyl-CoA desaturase 1

SDF-1

stromal cell-derived factor 1

SLC7A11

cystine transporter solute carrier family 7 member 11

SOD2

superoxide dismutase 2

STAT

signal transducers and activators of transcription

T-ALL

T-lineage acute lymphoblastic leukemia

THC

Δ9-tetrahydrocannabinol

THCV

tetrahydrocannabivarin

TNBC

triple-negative breast cancer

TNF-α

tumor necrosis factor-α

TRAIL

tumor necrosis factor-related apoptosis-inducing ligand

TRPV

transient receptor potential vanilloid

UBE2C

ubiquitin conjugating enzyme E2 C

VEGF

vascular endothelial growth factor

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