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Cannabidiol and Parkinson's disease: Investigating receptor interactions and their therapeutic implications
Parkinson's disease (PD) is a neurodegenerative condition characterised by the death of dopaminergic neurons predominantly...
Formylpeptide receptors: A novel target to treat cardiometabolic complications
The formylpeptide receptor (FPR) family, particularly FPR2, has emerged as a master regulator of inflammation and its reso...
A map of molecular drug targets and therapeutics for the US FDA-approved drugs: The impact of expedited regulatory pathways and first-in-class drug approvals on drug innovation
The fundamental objective of pharmaceutical research is to develop safe and effective medicines for treating diseases and ...
Molecular, metabolic, and histological subtypes of pancreatic ductal adenocarcinoma and its tumor microenvironment: Insights into tumor heterogeneity and clinical implications
AIArtificial intelligenceapCAFsAntigen-presenting CAFsATAC-seqAssay for Transposase-Accessible Chromatin using sequencingC...
Drug discovery through biophysical techniques: Methods and applications
The transition of drug discovery from serendipitous observation to a precise, interdisciplinary science has been propelled...
Treatment approaches for alcohol use disorder with metabolic dysfunction
Alcohol use disorders (AUDs) are among the most prevalent yet undertreated mental health conditions, affecting more than 7...
RNA renaissance: Harnessing non-coding RNA therapeutics for hepatocellular carcinoma
Liver cancer remains a major health burden worldwide despite significant advancements of its therapeutic strategies (Saman...
Cell phenotypic conversion and fate change during the host defense response, tissue injury and repair
Injurious challenges, including infection by pathogenic microbes, exposure to toxins or toxic agents, and trauma, frequent...
RNA-based drugs: current, imminent and possible therapeutic applications
ABC-DLBCLactivated B-cell subtype of diffuse large B-cell lymphomaACE-Iangiotensin converting enzyme inhibitorAGXTalanine-...
Next-generation nanocarriers for therapeutic oligonucleotides: Precision targeting and stimuli-responsive cancer therapy
Cancer remains one of the leading causes of mortality worldwide (Wu et al., 2024). Traditional treatments such as radiothe...
Corrigendum to “Drug discovery through biophysical techniques: Methods and applications” [pharmacology and therapeutics volume 277 (2026) 108947]
Volume 277, January 2026, 108961Author links open overlay panelYinhao Zhou, Haiyun Hu, Qiuyan Huang, Yuwei Tang, Yanli Liu...
Oxidative stress and antioxidant therapeutic mechanisms
Oxidative stress plays a crucial role in cellular physiology, influencing both normal biological processes and disease pat...
Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy
Inherited cardiomyopathies are a major cause of heart failure in all age groups, often with an onset in adolescence or ear...
Unlocking the power of affibody conjugated radioactive metallopharmaceuticals for targeted cancer diagnosis and therapy
Cancer is a complex, multifactorial disease and is the second leading cause of death worldwide. WHO reports that 1 in 6 mo...
Investigation into biased signaling, glycosylation, and drug vulnerability of acute myeloid leukemia
Biased signaling, also known as functional selectivity of receptors, describes a phenomenon where the same receptor can el...
G-protein coupled receptors in metabolic reprogramming and cancer
G-protein coupled receptors (GPCR) are one of the frequently investigated drug targets. GPCRs are involved in many human p...
Where are we now? Biased signalling of Class B G protein-coupled receptor-targeted therapeutics
Volume 270, June 2025, 108846Author links open overlay panel, , , , AbstractClass B G protein-coupled receptors (GPCRs) ar...
The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy
Metabolic syndrome (MetS), also known as X Syndrome, is a multifactorial cluster of pathologic conditions significantly in...
Resetting the aging clock through epigenetic reprogramming: Insights from natural products
Aging is an intricate process characterized by decreased functional abilities and increased susceptibility of various dise...
Cardiovascular therapeutic targets of sodium-glucose co-transporter 2 (SGLT2) inhibitors beyond heart failure
KeywordsSGLT2 inhibitorsAcute coronary syndromeChronic coronary syndromeArrhythmiasCardiomyopathiesValvular heart diseaseC...
Effect of cannabinoids on the efficacy and side effects of anticancer therapeutic strategies – Current status of preclinical and clinical research
2-AG2-arachidonylglycerolABCadenosine triphosphate-binding cassetteACEAarachidonyl-2′-chloroethylamideACPAarachidonoylcycl...
Therapeutic potential of natural flavonoids in atherosclerosis through endothelium-protective mechanisms: An update
Cardiovascular disease (CVD) prevails as a leading cause of death worldwide, which has become a significant public health ...
USP1 inhibition: A journey from target discovery to clinical translation
The DNA Damage Response (DDR) is a complex network comprising sensors, transducers, and effectors that collaboratively man...
Retina-directed gene therapy: Achievements and remaining challenges
Gene therapy is an innovative medical approach that offers new treatment options for congenital and acquired diseases by t...
Organic cation transporters in psychiatric and substance use disorders
Organic cation transporters in psychiatric and substance use disorders
Psychiatric and substance use disorders pose significant public health burdens across the globe. An estimated 970 million ...
Clinical advances in TNC delivery vectors and their conjugate agents
Clinical advances in TNC delivery vectors and their conjugate agents
Tenascin C (TNC), a glycoprotein that is abundant in the tumor extracellular matrix (ECM), is strongly overexpressed in tu...
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases
Available online 7 December 2023, 108576Author links open overlay panel, , , , , , , , , , AbstractRNA ac4C modification i...
Hypertension & dementia: Pathophysiology & potential utility of antihypertensives in reducing disease burden
Hypertension & dementia: Pathophysiology & potential utility of antihypertensives in reducing disease burden
Dementia is a progressive neurodegenerative disease that develops most commonly in late adulthood and is predominantly cha...
Repurposing of pexidartinib for microglia depletion and renewal
Repurposing of pexidartinib for microglia depletion and renewal
Available online 3 December 2023, 108565Author links open overlay panel, , , AbstractPexidartinib (PLX3397) is a small mol...
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions
Retracing our steps: A review on autism research in children, its limitation and impending pharmacological interventions
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by three core impairments: impaired communic...
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