Cardiovascular therapeutic targets of sodium-glucose co-transporter 2 (SGLT2) inhibitors beyond heart failure

Keywords

SGLT2 inhibitors

Acute coronary syndrome

Chronic coronary syndrome

Arrhythmias

Cardiomyopathies

Valvular heart disease

Chronic kidney disease

AbbreviationsAMI

Acute myocardial infarction

AMPK

Adenosine monophosphate-activated protein kinase

BDNF

Brain-derived neurotrophic factor

CAD

Coronary artery disease

CaMKII

Calcium/calmodulin-dependent protein kinase II

CKD

Chronic kidney disease

CNS

Central nervous system

CTRCD

Cancer therapy-related cardiac dysfunction

DAD

Delayed after depolarization

DCM

Dilated cardiomyopathy

eGFR

Estimated glomerular filtration rate

EVCD

Extra-valvular cardiac damage

EVs

Extracellular vesicles

FISH

Fluorescent in situ hybridization

GDMT

Guideline-directed medical therapy

GLP-1

Glucagon-like peptide 1

GSK3β

Glycogen synthase kinase-3 β

HCM

Hypertrophic cardiomyopathy

HIF-1α/VEGF

Hypoxia-inducible factor-1α/Vascular endothelial growth factor

HFpEF

Heart failure with preserved ejection fraction

HFrEF

Heart failure with reduced ejection fraction

IHD

Ischemic heart disease

LQT3

Long QT syndrome type 3

LVEF

Left ventricular ejection fraction

M-TEER

Mitral valve transcatheter edge-to-edge repair

NF-kB

Nuclear factor-kappa B

NHE

Sodium/hydrogen exchanger

PCI

Percutaneous coronary intervention

PDL1

Programmed death-ligand 1

PI3K/AKT

Phosphoinositide 3-kinase / Protein kinase B

RAAS

Renin-angiotensin-aldosterone system

RCT

Randomized clinical trial

ROS

Reactive oxygen species

RyR2

Ryanodine receptors 2

SGLT2

Sodium-glucose co-transporter 2

SOD2

Superoxide dismutase 2

STAT3

Signal transducer and activator of transcription 3

T2DM

Type 2 diabetes mellitus

TAVI

Transcatheter aortic valve implantation

TGF-β

Transforming growth factor-beta

VAs

Ventricular arrhythmias

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