Aging is an intricate process characterized by decreased functional abilities and increased susceptibility of various diseases, including cardiovascular diseases, cancer, neurodegenerative disorders, immune system dysfunctions, endocrine and metabolic diseases, etc. (Abdelgawad et al., 2021; Park et al., 2023). Research has identified key aging hallmarks, such as genetic instability, telomere shortening, mitochondrial damage, epigenetic changes, abnormal cellular metabolism (Birch, Barnes, & Passos, 2018; Denomme et al., 2024; Milosic, Hengstschlager, & Osmanagic-Myers, 2023; Siddiqui, Sharma, Kesharwani, & Parihar, 2024), all of which play pivotal roles in the development of aging. These insights are fundamental for identifying aging biomarkers and developing age-related diseases interventions.

Natural products are bioactive compounds sourced from plants, animals, marine organisms, microorganisms, and other natural sources, known for their diverse chemical structures and pharmacological properties (Luo, Yin, Wang, & Kong, 2024; Zhang et al., 2020). These compounds have been extensively studied for their potential in various therapeutic applications, including anti-aging effects and modulation of epigenetic modifications. This review aims to provide a comprehensive overview of natural products that target epigenetic reprogramming to enhance longevity and alleviate age-related organ dysfunctions.