Matthias Augustin: Abbott/AbbVie, Almirall, Amgen Inc., Beiersdorf, Biogen Idec, Bristol Myers Squibb, Boehringer Ingelheim, Celgene, Centocor, Dermira, Eli Lilly, Fresenius, Galderma, GlaxoSmithKline, Hexal, Incyte, Janssen-Cilag, LEO Pharma, Lilly, Medac, Merck, MSD, Mylan, Novartis, Pfizer, Regeneron, Sandoz, UCB, and XenoPort—consultant, paid speaker, and/or has received research grants/honoraria. Jonathan Barker: AbbVie, Almirall, Amgen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Samsung, Sienna, Sun Pharma, and UCB—participated in advisory boards, received consultancy fees, spoke at sponsored symposia, and/or received grant funding. Curdin Conrad: AbbVie, Actelion, Almirall, Amgen Inc., Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Janssen, LEO Pharma, Eli-Lilly, MSD, Novartis, Pfizer, Samsung, and UCB—honoraria and/or research grants. Denis Jullien: AbbVie, Almirall, Amgen, Biogen, Boehringer Ingelheim, Celgene, Fresenius-Kabi, Janssen-Cilag, LEO Pharma, Lilly, Medac, MSD, Novartis, Pfizer, Sanofi, and UCB—consultant, speaker, investigator, scientific officer, steering committee member, and/or advisory board member. Jose-Manuel Carrascosa: Abbott/AbbVie, Almirall, Amgen Inc., Beiersdorf, Bristol Myers Squibb, Boehringer Ingelheim, Celgene, Eli Lilly, Fresenius, Galderma, Incyte, Janssen-Cilag, LEO Pharma, Novartis, Pfizer, Sandoz, UCB, Sanofi-Aventis, Pfizer, Janssen—consultant, paid speaker, and/or has received research grants/honoraria. Jyotsna Reddy, Hamid Amouzadeh, Stephen Colgan, and Henry Zou: Amgen Inc.—employees and stockholders. Ulrich Mrowietz: AbbVie, Aditxt, Almirall, Amgen Inc., Aristea, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Dr. Reddy’s, Eli Lilly, Foamix, Formycon, Immunic, Janssen, LEO Pharma, Medac, MetrioPharm, Novartis, Phi-Stone, Pierre Fabre, Sanofi-Aventis, and UCB Pharma, UNION therapeutics—advisor, received speakers’ honoraria, received grants, and/or participated in clinical trials.

The study was approved by the institutional review board/ethics committee at each site before commencement and conducted in compliance with Good Clinical Practice, the International Council for Harmonisation Guideline E6, the Declaration of Helsinki, and applicable regulatory requirements (Supplementary Table S1). Patients provided written informed consent before study-related procedures.