Mervyn Singer CS, Deutschman CW, Seymour, et al. The third international consensus definitions for Sepsis and septic shock (Sepsis-3). JAMA. 2016;315:801–10. https://doi.org/10.1001/jama.2016.0287.
Article CAS PubMed PubMed Central Google Scholar
Kristina E, Rudd SC, Johnson KM, Agesa, et al. Global, regional, and National sepsis incidence and mortality, 1990–2017: analysis for the global burden of disease study. Lancet (London England). 2020;395:200–11. https://doi.org/10.1016/S0140-6736(19)32989-7.
Weng L, Zeng Xy, Yin P, et al. Sepsis-related mortality in China: a descriptive analysis. Intensive Care Med. 2018. https://doi.org/10.1007/s00134-018-5203-z. 44:.
Jianfeng Xie H, Wang Y, Kang, et al. The epidemiology of Sepsis in Chinese ICUs: A National Cross-Sectional survey. Crit Care Med. 2020;48:e209. https://doi.org/10.1097/CCM.0000000000004155.
Benjamin G, Chousterman FK, Swirski, Georg F, Weber. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017;39:517–28. https://doi.org/10.1007/s00281-017-0639-8.
Lieuwe DJ, Bos, Lorraine B, Ware. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet (London England). 2022;400:1145–56. https://doi.org/10.1016/S0140-6736(22)01485-4.
Giacomo Bellani JG, Laffey, Tài P, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315:788–800. https://doi.org/10.1001/jama.2016.0291.
Article CAS PubMed Google Scholar
Chau-Chyun Sheu MN, Gong R, Zhai, et al. Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS. Chest. 2010;138:559–67. https://doi.org/10.1378/chest.09-2933.
Article CAS PubMed PubMed Central Google Scholar
Zhize Yuan Q, Wang Y, Tan, et al. Methylprednisolone alleviates lung injury in sepsis by regulating miR-151-5p/USP38 pathway. Int Immunopharmacol. 2024;138:112548. https://doi.org/10.1016/j.intimp.2024.112548.
Article CAS PubMed Google Scholar
Tu G-W, Shi Y, Zheng Y-J, et al. Glucocorticoid attenuates acute lung injury through induction of type 2 macrophage. J Transl Med. 2017;15:181. https://doi.org/10.1186/s12967-017-1284-7.
Article CAS PubMed PubMed Central Google Scholar
Mengting Qin Z Qiu. Changes in TNF-α, IL-6, IL-10 and VEGF in rats with ARDS and the effects of dexamethasone. Exp Ther Med. 2019;17:383–7. https://doi.org/10.3892/etm.2018.6926.
Article CAS PubMed Google Scholar
Bruno M, Tomazini IS, Maia AB, Cavalcanti, et al. Effect of dexamethasone on days alive and Ventilator-Free in patients with moderate or severe acute respiratory distress syndrome and COVID-19: the CoDEX randomized clinical trial. JAMA. 2020;324:1307. https://doi.org/10.1001/jama.2020.17021.
Jesús Villar C, Ferrando D, Martínez, et al. Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Lancet Respiratory Med. 2020;8:267–76. https://doi.org/10.1016/S2213-2600(19)30417-5.
Pierre-François Dequin F, Meziani J-P, Quenot, et al. Hydrocortisone in severe Community-Acquired pneumonia. N Engl J Med. 2023;388:1931–41. https://doi.org/10.1056/NEJMoa2215145.
Vito Fanelli Y, Morita P, Cappello, et al. Neuromuscular blocking agent cisatracurium attenuates lung injury by Inhibition of nicotinic acetylcholine Receptor-α1. Anesthesiology. 2016;124:132–40. https://doi.org/10.1097/ALN.0000000000000907.
Article CAS PubMed Google Scholar
Peter D, Sottile D, Albers MM, Moss. Neuromuscular Blockade is associated with the Attenuation of biomarkers of epithelial and endothelial injury in patients with moderate-to-severe acute respiratory distress syndrome. Crit Care (London England). 2018;22:63. https://doi.org/10.1186/s13054-018-1974-4.
Forel J-M, Roch A, Valérie Marin, et al. Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome. Crit Care Med. 2006;34:2749–57. https://doi.org/10.1097/01.CCM.0000239435.87433.0D.
Article CAS PubMed Google Scholar
Nur Canbolat B, Ozkul IH, Sever, et al. Vitamins C and E protect from sepsis-induced lung damage in rat and CT correlation. Bratisl Lek Listy. 2022;123:828–32. https://doi.org/10.4149/BLL_2022_132.
Bernard J, Fisher D, Kraskauskas EJ, Martin, et al. Mechanisms of Attenuation of abdominal sepsis induced acute lung injury by ascorbic acid. Am J Physiol Lung Cell Mol Physiol. 2012;303:L20–32. https://doi.org/10.1152/ajplung.00300.2011.
Bassem M, Mohammed BJ, Fisher D, Kraskauskas, et al. Vitamin C: a novel regulator of neutrophil extracellular trap formation. Nutrients. 2013;5:3131–51. https://doi.org/10.3390/nu5083131.
Xian Qiao MG, Kashiouris ML’Heureux, et al. Biological effects of intravenous vitamin C on neutrophil extracellular traps and the endothelial glycocalyx in patients with Sepsis-Induced ARDS. Nutrients. 2022;14:4415. https://doi.org/10.3390/nu14204415.
Article CAS PubMed PubMed Central Google Scholar
Alpha A, Fowler JD, Truwit R, Duncan Hite, et al. Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with Sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial. JAMA. 2019;322:1261–70. https://doi.org/10.1001/jama.2019.11825.
Gao D, Xu M, Wang G, et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study. Aging. 2021;13:7020–34. https://doi.org/10.18632/aging.202557.
Article CAS PubMed PubMed Central Google Scholar
Paul E, Marik V, Khangoora R, Rivera, et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe Sepsis and septic shock: A retrospective Before-After study. Chest. 2017;151:1229–38. https://doi.org/10.1016/j.chest.2016.11.036.
Fei Y, Huang X, Ning F, et al. NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1/HS and downstream pathways. Biomedecine Pharmacotherapie. 2024;175:116621. https://doi.org/10.1016/j.biopha.2024.116621.
Article CAS PubMed Google Scholar
Kodai Suzuki H, Okada G, Takemura, et al. Neutrophil elastase damages the pulmonary endothelial glycocalyx in Lipopolysaccharide-Induced experimental endotoxemia. Am J Pathol. 2019;189:1526–35. https://doi.org/10.1016/j.ajpath.2019.05.002.
Article CAS PubMed Google Scholar
Jiajia Ren G, Deng R, Li, et al. Possible Pharmacological targets and mechanisms of Sivelestat in protecting acute lung injury. Comput Biol Med. 2024;170:108080. https://doi.org/10.1016/j.compbiomed.2024.108080.
Article CAS PubMed Google Scholar
Yoshiaki Tsuboko S, Takeda S, Mii, et al. Clinical evaluation of Sivelestat for acute lung injury/acute respiratory distress syndrome following surgery for abdominal sepsis. Drug Des Devel Ther. 2012;6:273–8. https://doi.org/10.2147/DDDT.S36436.
Article CAS PubMed PubMed Central Google Scholar
Xiao C, Hu W, Zhang Z, et al. Efficacy analysis and prognostic impact of Sivelestat sodium in coronavirus disease 2019-Related acute respiratory distress syndrome. Pharmaceuticals (Basel Switzerland). 2024;17:368. https://doi.org/10.3390/ph17030368.
Lv H, Huang L, Yang X, et al. The clinical effectiveness of Sivelestat in treating sepsis patients with both acute respiratory distress syndrome and septic cardiomyopathy. J Cardiothorac Surg. 2024;19:399. https://doi.org/10.1186/s13019-024-02835-3.
Comments (0)