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Integrative multi-omics identifies CYP1B1 as a candidate molecular link between toxicant exposure and ferroptosis-related epithelial stress in COPD
Integrative multi-omics identifies CYP1B1 as a candidate molecular link between toxicant exposure and ferroptosis-related epithelial stress in COPD
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation, chronic airway inflammati...
From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases
From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases
Autoimmune diseases (AIDs) are characterized by disrupted immune tolerance, chronic inflammation, and organ-specific tissu...
Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production
Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production
Aberrant activation of the NLRP3 inflammasome contributes to the development of multiple inflammatory disorders, but clini...
Myeloid PKM2 deficiency alleviates allergic airway inflammation and promotes macrophage efferocytosis via SLC13A3
Myeloid PKM2 deficiency alleviates allergic airway inflammation and promotes macrophage efferocytosis via SLC13A3
Allergic asthma is characterized by chronic airway inflammation that fails to resolve efficiently. Defective efferocytosis...
Lipopolysaccharide-mediated macrophage polarization, conserved pathogenesis, and implications for peripheral neuropathy: a systematic review
Lipopolysaccharide-mediated macrophage polarization, conserved pathogenesis, and implications for peripheral neuropathy: a systematic review
This systematic review synthesized evidence for a conserved lipopolysaccharide (LPS)-mediated pathogenic mechanism across ...
Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease
Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease
A20 is an anti-inflammatory protein that suppresses nuclear factor-κB (NF-κB)-mediated inflammatory gene express...
SERPINE1 in ARDS: an emerging regulator of inflammation–coagulation–fibrinolysis crosstalk
SERPINE1 in ARDS: an emerging regulator of inflammation–coagulation–fibrinolysis crosstalk
This narrative review synthesizes current evidence on the role of SERPINE1/PAI-1 in acute respiratory distress syndrome (A...
NKRCD8 T cells and iNKT cells protect mice from AOM/DSS-induced colorectal cancer under conditions of IFNγ-mediated hyperinflammation
NKRCD8 T cells and iNKT cells protect mice from AOM/DSS-induced colorectal cancer under conditions of IFNγ-mediated hyperinflammation
Interferon-gamma (IFNγ) is a pivotal cytokine in immune surveillance and inflammation, yet its precise role in colore...
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects
Extracellular vesicles (EVs) are intercellular mediators in prokaryotic and eukaryotic systems that have the potential to ...
Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease
Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease
Peripheral helper T cells represent a recently characterized subset of CD4+ T cells present in inflammatory bowel disease ...
International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study
International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study
The dynamics of cell surface marker expression on systemic neutrophils provide valuable insights into the post-traumatic i...
MICA gene modulates immune microenvironment and comorbid mechanisms in diffuse large B-cell lymphoma and primary Sjögren’s syndrome
MICA gene modulates immune microenvironment and comorbid mechanisms in diffuse large B-cell lymphoma and primary Sjögren’s syndrome
To identify shared molecular mechanisms and crosstalk genes (CGs) between diffuse large B-cell lymphoma (DLBCL) and primar...
TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury
TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury
Sepsis-induced acute lung injury (ALI) is characterized by edema resulting from increased vascular permeability. Transient...
Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps
Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps
Lysophosphatidic acid (LPA) has been extensively reviewed in receptor pharmacology, fibrosis, cancer, vascular biology and...
infection reduces CD59 expression through downregulation of JAK2/STAT3 signaling axis to enhance decidual NK cell cytotoxicity via the RAS/MAPK pathway
infection reduces CD59 expression through downregulation of JAK2/STAT3 signaling axis to enhance decidual NK cell cytotoxicity via the RAS/MAPK pathway
Toxoplasma gondii (T. gondii) infection disrupts pregnancy by modulating decidual natural killer (dNK) cells function. Thi...
LncRNA SNHG14 drives alveolar inflammation in bronchopulmonary dysplasia via DNMT3a-mediated epigenetic silencing of miR-214-3p
LncRNA SNHG14 drives alveolar inflammation in bronchopulmonary dysplasia via DNMT3a-mediated epigenetic silencing of miR-214-3p
This experimental study investigated whether lncRNA SNHG14 contributes to hyperoxia-associated bronchopulmonary dysplasia ...
GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling
GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling
Atherosclerosis (AS) is a chronic inflammatory disorder with substantial global prevalence, wherein macrophage polarizatio...
Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis
Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis
This narrative review synthesizes current evidence on the immunopathogenesis of autoimmune uveitis(AU), with particular em...
Distinct miRNA expression patterns in circulating eosinophil subtypes and their subtype-derived exosomes in allergic asthma
Distinct miRNA expression patterns in circulating eosinophil subtypes and their subtype-derived exosomes in allergic asthma
Lung-resident (rEos) and inflammatory (iEos) eosinophil subtypes were initially characterized in mouse models of asthma an...
Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease
Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease
High phosphate levels lead to significant pathological changes in vascular smooth muscle cells (VSMCs) and endothelial cel...
The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review
The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review
Psoriatic disease (PsD) is a chronic systemic inflammatory condition associated with significant cardiometabolic comorbidi...
Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study
Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study
Periodontitis has been associated with an increased risk of atherosclerotic cardiovascular disease; however, its associati...
Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation
Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation
Sepsis and heatstroke, although arising from microbial infection or environmental heat exposure, converge upon similar pat...
Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
Rosacea is a chronic inflammatory skin disorder characterized by symptoms like itching, redness, and impaired skin barrier...
Angiotensin-(1-7) treatment improves pneumonia and prevents sepsis caused by pneumococcal infection
Angiotensin-(1-7) treatment improves pneumonia and prevents sepsis caused by pneumococcal infection
Pneumonia caused by Streptococcus pneumoniae remains a major global health concern, leading to significant morbidity and m...
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Skin lesions in atopic dermatitis (AD) are characterized by elevated levels of both Th1 and Th2 cytokines, along with incr...
Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity
Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity
Kinins, bioactive peptides produced through the proteolytic activity of kallikrein1, are members of the kallikrein-kinin s...
Target Fibroblast-B cell crosstalk via MIF signaling drives pathogenic B cell differentiation and joint damage in knee osteoarthritis
Target Fibroblast-B cell crosstalk via MIF signaling drives pathogenic B cell differentiation and joint damage in knee osteoarthritis
B cells play a critical role in knee osteoarthritis (KOA), however, the heterogeneity, activation mechanisms, and their co...
Novel insights into asthma pathophysiology and pharmacological interventions: spiral of respiratory symptoms and psychiatric episodes
Novel insights into asthma pathophysiology and pharmacological interventions: spiral of respiratory symptoms and psychiatric episodes
Asthma is the most common respiratory disorder with airway inflammation and alterations. Included among comorbidities with...
Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation—a review of current literature
Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation—a review of current literature
Inflammatory pain arises from tissue stress or injury and is initiated by signaling molecules that stimulate the immune an...
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