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The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review
The potential role of GLP-1 receptor agonists in the management of psoriatic disease: a scoping review
Psoriatic disease (PsD) is a chronic systemic inflammatory condition associated with significant cardiometabolic comorbidi...
Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study
Periodontitis, subclinical myocardial injury, and cardiovascular mortality among US adults: a population-based study
Periodontitis has been associated with an increased risk of atherosclerotic cardiovascular disease; however, its associati...
Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation
Sepsis and heatstroke: overlapping and distinct mechanisms of systemic inflammation
Sepsis and heatstroke, although arising from microbial infection or environmental heat exposure, converge upon similar pat...
Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice
Rosacea is a chronic inflammatory skin disorder characterized by symptoms like itching, redness, and impaired skin barrier...
Angiotensin-(1-7) treatment improves pneumonia and prevents sepsis caused by pneumococcal infection
Angiotensin-(1-7) treatment improves pneumonia and prevents sepsis caused by pneumococcal infection
Pneumonia caused by Streptococcus pneumoniae remains a major global health concern, leading to significant morbidity and m...
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis
Skin lesions in atopic dermatitis (AD) are characterized by elevated levels of both Th1 and Th2 cytokines, along with incr...
Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity
Kinin receptors in adipose tissue: drivers of inflammation and metabolic dysfunction in obesity
Kinins, bioactive peptides produced through the proteolytic activity of kallikrein1, are members of the kallikrein-kinin s...
Target Fibroblast-B cell crosstalk via MIF signaling drives pathogenic B cell differentiation and joint damage in knee osteoarthritis
Target Fibroblast-B cell crosstalk via MIF signaling drives pathogenic B cell differentiation and joint damage in knee osteoarthritis
B cells play a critical role in knee osteoarthritis (KOA), however, the heterogeneity, activation mechanisms, and their co...
Novel insights into asthma pathophysiology and pharmacological interventions: spiral of respiratory symptoms and psychiatric episodes
Novel insights into asthma pathophysiology and pharmacological interventions: spiral of respiratory symptoms and psychiatric episodes
Asthma is the most common respiratory disorder with airway inflammation and alterations. Included among comorbidities with...
Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation—a review of current literature
Inflammatory pain and electroacupuncture: how the P2X3 receptor can help modulate inflammation—a review of current literature
Inflammatory pain arises from tissue stress or injury and is initiated by signaling molecules that stimulate the immune an...
impairs autophagy and Aβ clearance by microglial cells
impairs autophagy and Aβ clearance by microglial cells
Alzheimer’s disease (AD) is a predominant form of dementia in elderly. In sporadic AD and in families with higher ri...
Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study
Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study
This study aimed to identify the potential inflammatory molecular biomarkers that could be utilized for the early predicti...
Alveolar macrophages polarization switch via α-adrenoceptor activation ameliorates pulmonary inflammation following kidney ischemia reperfusion
Alveolar macrophages polarization switch via α-adrenoceptor activation ameliorates pulmonary inflammation following kidney ischemia reperfusion
The present study aimed to explore the anti-inflammatory mechanism of dexmedetomidine (Dex), an α2-adrenoceptor (^...
SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury
SARS-CoV-2 nucleocapsid protein induces a Mincle-dependent macrophage inflammatory response in acute kidney injury
Although the COVID-19 pandemic has receded, the SARS-CoV-2 virus still poses a significant threat to individuals with pre-...
TIPE2 deficiency amplifies inflammation and immune dysregulation in MASH through modulating hepatic lipid metabolism and immune cell function
TIPE2 deficiency amplifies inflammation and immune dysregulation in MASH through modulating hepatic lipid metabolism and immune cell function
Metabolic Dysfunction-Associated Steatohepatitis (MASH) affects nearly 25% of the global population, yet there are no effe...
RAGE deficiency ameliorates abdominal aortic aneurysm progression
RAGE deficiency ameliorates abdominal aortic aneurysm progression
Abdominal aortic aneurysm (AAA) is a vascular disease characterized by inflammation and arterial wall degradation. The rec...
Single-cell hdWGCNA reveals a novel diagnostic model and signature genes of macrophages associated with chronic obstructive pulmonary disease
Single-cell hdWGCNA reveals a novel diagnostic model and signature genes of macrophages associated with chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory system-related mortality worldwide. Altho...
Accelerating and protective effects toward cancer growth in cGAS and FcgRIIb deficient mice, respectively, an impact of macrophage polarization
Accelerating and protective effects toward cancer growth in cGAS and FcgRIIb deficient mice, respectively, an impact of macrophage polarization
Due to the possible influence of inflammation and gut microbiota in cancers. Fc gamma receptor IIb deficient (FcGRIIbͨ...
Eosinophils but not mast cells exert anti-tumorigenic activity, without being predictive markers of the long-term response to Bacillus Calmette-Guérin (BCG) therapy in patients with bladder carcinoma
Eosinophils but not mast cells exert anti-tumorigenic activity, without being predictive markers of the long-term response to Bacillus Calmette-Guérin (BCG) therapy in patients with bladder carcinoma
Bacillus Calmette-Guerin (BCG) therapy is an established immunotherapy for non-muscle invasive bladder cancer (NMIBC); how...
Effects of remote ischemic preconditioning and/or erythropoietin on lung injury induced by skeletal ischemia reperfusion: role of the NLRP3 inflammasome
Effects of remote ischemic preconditioning and/or erythropoietin on lung injury induced by skeletal ischemia reperfusion: role of the NLRP3 inflammasome
Remote ischemic preconditioning (RIPC) diminishes multi-organ failure induced by skeletal muscle ischemia and reperfusion ...
Advances in anti-inflammatory treatment of sepsis-associated acute respiratory distress syndrome
Advances in anti-inflammatory treatment of sepsis-associated acute respiratory distress syndrome
Sepsis is characterized by a dysregulated host response to infection, leading to organ dysfunction and associated with sig...
Identification of ferroptosis-related genes and potential drugs in osteoarthritis
Identification of ferroptosis-related genes and potential drugs in osteoarthritis
Osteoarthritis (OA) is a common chronic degenerative joint disease in orthopedics, and ferroptosis is a newly identified m...
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo
Psychological stress is the most common psychological comorbidity and a significant triggering factor of vitiligo. Moderat...
Nrf2 mediated signaling axis in sepsis-induced cardiomyopathy: potential Pharmacological receptor
Nrf2 mediated signaling axis in sepsis-induced cardiomyopathy: potential Pharmacological receptor
Sepsis has emerged as the most pressing health concerns globally in emergency and intensive care unit. Sepsis-Induced Card...
The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases
The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases
Fatty acid metabolism plays a critical role in regulating immune cell function, including B cells, which are central to hu...
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia
The immune system is essential for immuno-surveillance and the generation of anti-tumor immunity. However, the role of imm...
COVID-19 mRNA-1273 vaccination induced mast cell activation with strongly elevated Th cytokines in a systemic mastocytosis patient
COVID-19 mRNA-1273 vaccination induced mast cell activation with strongly elevated Th cytokines in a systemic mastocytosis patient
SARS-CoV-2 vaccines are recommended for mastocytosis patients. We describe clinical symptoms, chemokine, cytokine, metabol...
Paricalcitol promotes the maturation of immune granulomas in an experimental model of superoxide dismutase A-induced inflammation
Paricalcitol promotes the maturation of immune granulomas in an experimental model of superoxide dismutase A-induced inflammation
– Granulomatous inflammation is a hallmark of several chronic inflammatory diseases, characterized by the formation ...
Serine metabolism in macrophage polarization
Serine metabolism in macrophage polarization
Emerging studies have revealed that macrophages possess different dependences on the uptake, synthesis, and metabolism of ...
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression
Atherosclerosis, characterized by abnormal arterial lipid deposition, is an age-dependent inflammatory disease and contrib...
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