Effects of remote ischemic preconditioning and/or erythropoietin on lung injury induced by skeletal ischemia reperfusion: role of the NLRP3 inflammasome

Kumar K, Railton C, Tawfic Q. Tourniquet application during anesthesia: “what we need to know?” J Anaesthesiol Clin Pharmacol. 2016;32:424–30.

Article  PubMed  PubMed Central  Google Scholar 

Ergün Y, Kılınç M, Aral M, Hedef A, Kaya E. Protective effect of epigallocatechin gallate in ischemia-reperfusion injury of rat skeletal muscle. J Surg Res. 2020;247:1–7.

Article  PubMed  Google Scholar 

Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med. 2011;17:1391–401.

Article  CAS  PubMed  Google Scholar 

Barnig C, Lutzweiler G, Giannini M, Lejay A, Charles AL, Meyer A, et al. Resolution of inflammation after skeletal muscle ischemia-reperfusion injury: a focus on the lipid mediators lipoxins, resolvins, protectins and maresins. Antioxidants. 2022;11:1213.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orhan M, Taş Tuna A, Ünal Y, Arslan M, Yazar H, Sezen ŞC, et al. The effects of amantadine on lung tissue in lower limb ischemia/reperfusion injury model in rats. Turk Gogus Kalp Damar Cerrahisi Derg. 2021;29:77–83.

Article  PubMed  PubMed Central  Google Scholar 

Gu W, Zeng Q, Wang X, Jasem H, Ma L. Acute lung injury and the NLRP3 inflammasome. J Inflamm Res. 2024;17:3801–13.

Article  PubMed  PubMed Central  Google Scholar 

Zhong C, Xie Y, Wang H, Chen W, Yang Z, Zhang L, et al. Berberine inhibits NLRP3 inflammasome activation by regulating mTOR/mtROS axis to alleviate diabetic cardiomyopathy. Eur J Pharmacol. 2024;964: 176253.

Article  CAS  PubMed  Google Scholar 

Sayaf K, Battistella S, Russo FP. NLRP3 inflammasome in acute and chronic liver diseases. Int J Mol Sci. 2024;25:4537.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao S, Fan W, Liu J, Wang T, Zheng H, Qi G, et al. NLRP3 inflammasome: an emerging therapeutic target for Alzheimer’s disease. J Alzheimers Dis. 2023;96:1383–98.

Article  CAS  PubMed  Google Scholar 

Tall AR, Bornfeldt KE. Inflammasomes and atherosclerosis: a mixed picture. Circ Res. 2023;132:1505–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El-Sisi AEE, Sokar SS, Shebl AM, Mohamed DZ, Abu-Risha SE. Octreotide and melatonin alleviate inflammasome-induced pyroptosis through inhibition of TLR4-NF-κB-NLRP3 pathway in hepatic ischemia/reperfusion injury. Toxicol Appl Pharmacol. 2021;410: 115340.

Article  CAS  PubMed  Google Scholar 

Sun NN, Yu CH, Pan MX, Zhang Y, Zheng BJ, Yang QJ, et al. Mir-21 mediates the inhibitory effect of Ang (1–7) on AngII-induced NLRP3 inflammasome activation by targeting spry1 in lung fibroblasts. Sci Rep. 2017;7:14369.

Article  PubMed  PubMed Central  Google Scholar 

Ying Y, Mao Y, Yao M. NLRP3 inflammasome activation by MicroRNA-495 promoter methylation may contribute to the progression of acute lung injury. Mol Ther Nucleic Acids. 2019;18:801–14.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Q, Yu S, Meng X, Shi M, Huang S, Li J, et al. MicroRNAs: important regulatory molecules in acute lung injury/acute respiratory distress syndrome. Int J Mol Sci. 2022;23:5545.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jelkmann W. Physiology and pharmacology of erythropoietin. Transfus Med Hemother. 2013;40:302–9.

Article  PubMed  PubMed Central  Google Scholar 

Ward JM, Ambatipudi M, O’Hanlon TP, Smith MA, de Los RM, Schiffenbauer A, et al. Shared and distinctive transcriptomic and proteomic pathways in adult and juvenile dermatomyositis. Arthritis Rheumatol. 2023;75:2014–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iso Y, Usui S, Suzuki H. Mesenchymal stem/stromal cells in skeletal muscle are pro-angiogenic, and the effect is potentiated by erythropoietin. Pharmaceutics. 2023;15:1049.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen AQ, Cherry BH, Scott GF, Ryou MG, Mallet RT. Erythropoietin: powerful protection of ischemic and post-ischemic brain. Exp Biol Med. 2014;239:1461–75.

Article  Google Scholar 

Vélez DE, Cordero VE, Hermann R, Pazos MD, Reznik FJ, Sánchez L, Prendes MG. Erythropoietin-mediated cardioprotection in hearts subjected to ischemia reperfusion. J Mol Endocrinol. 2023;71(3):e230076.

Article  PubMed  Google Scholar 

Kwak J, Kim JH, Jang HN, Jung MH, Cho HS, Chang SH, et al. Erythropoietin ameliorates ischemia/reperfusion-induced acute kidney injury via inflammasome suppression in mice. Int J Mol Sci. 2020;21:3453.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin X, Jin W, Li G, Zheng J, Xu X. Erythropoietin alleviates lung ischemia-reperfusion injury by activating the FGF23/FGFR4/ERK signaling pathway. PeerJ. 2024;12: e17123.

Article  PubMed  PubMed Central  Google Scholar 

Tasar P, Ozen Y. Effects of recombinant human erythropoietin and 2-mercaptoethane sulfonate on liver ischemia-reperfusion injury in rats. Exp Clin Transplant. 2024;22:358–65.

PubMed  Google Scholar 

Aapro M, Gascón P, Patel K, Rodgers GM, Fung S, Arantes LH Jr, et al. Erythropoiesis-stimulating agents in the management of anemia in chronic kidney disease or cancer: a historical perspective. Front Pharmacol. 2018;9:1498.

Article  CAS  PubMed  Google Scholar 

Suresh S, Rajvanshi PK, Noguchi CT. The many facets of erythropoietin physiologic and metabolic response. Front Physiol. 2019;10:1534.

Article  PubMed  Google Scholar 

Pearce L, Galán-Arriola C, Bell RM, Carr RD, Cunningham J, Davidson SM, et al. Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th hatter cardiovascular institute workshop. Basic research in cardiology 2024:Online ahead of print.

Nordström J, Badia IMP, Witasp A, Schwarz A, Evenepoel P, Moor MB, et al. Defining the molecular response to ischemia-reperfusion injury and remote ischemic preconditioning in human kidney transplantation. PLoS ONE. 2024;19:e0311613.

Article  PubMed  PubMed Central  Google Scholar 

Lau JK, Roy P, Javadzadegan A, Moshfegh A, Fearon WF, Ng M, et al. Remote ischemic preconditioning acutely improves coronary microcirculatory function. J Am Heart Assoc. 2018;7: e009058.

Article  PubMed  PubMed Central  Google Scholar 

Zarbock A, Kellum JA. Remote ischemic preconditioning and protection of the kidney—a novel therapeutic option. Crit Care Med. 2016;44:607–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma D, Maslov LN, Singh N, Jaggi AS. Remote ischemic preconditioning-induced neuroprotection in cerebral ischemia-reperfusion injury: preclinical evidence and mechanisms. Eur J Pharmacol. 2020;883: 173380.

Article  CAS  PubMed  Google Scholar 

Kharbanda RK, Mortensen UM, White PA, Kristiansen SB, Schmidt MR, Hoschtitzky JA, et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation. 2002;106:2881–3.

Article  CAS  PubMed  Google Scholar 

Cai ZP, Parajuli N, Zheng X, Becker L. Remote ischemic preconditioning confers late protection against myocardial ischemia-reperfusion injury in mice by upregulating interleukin-10. Basic Res Cardiol. 2012;107:277.

Article  PubMed  PubMed Central  Google Scholar 

Fahmy SR, Gaafar K. Establishing the first institutional animal care and use committee in Egypt. Philos Ethics Humanit Med. 2016;11:2.

Comments (0)

No login
gif