Makvandi M, Dupis E, Engle JW, Nortier FM, Fassbender ME, Simon S, et al. Alpha-Emitters and targeted alpha therapy in oncology: from basic science to clinical investigations. Target Oncol. 2018;13:189–203. https://doi.org/10.1007/s11523-018-0550-9.
Sathekge M, Morgenstern A. Advances in targeted alpha therapy of cancer. Eur J Nucl Med Mol Imaging. 2024;51:1205–6. https://doi.org/10.1007/s00259-024-06658-1.
Poty S, Francesconi LC, McDevitt MR, Morris MJ, Lewis JS. α-Emitters for radiotherapy: from basic radiochemistry to clinical Studies-Part 1. J Nucl Med. 2018;59:878–84. https://doi.org/10.2967/jnumed.116.186338.
Article CAS PubMed PubMed Central Google Scholar
Kratochwil C, Haberkorn U, Giesel FL. 225Ac-PSMA-617 for therapy of prostate Cancer. Semin Nucl Med. 2020;50:133–40. https://doi.org/10.1053/j.semnuclmed.2020.02.004.
Parker C, Nilsson S, Heinrich D, Helle SI, O’Sullivan JM, Fosså SD, et al. Alpha emitter radium-223 and survival in metastatic prostate cancer. N Engl J Med. 2013;369:213–23. https://doi.org/10.1056/NEJMoa1213755.
Article CAS PubMed Google Scholar
Morgenstern A, Apostolidis C, Kratochwil C, Sathekge M, Krolicki L, Bruchertseifer F. An overview of targeted alpha therapy with 225Actinium and 213Bismuth. Curr Radiopharm. 2018;11:200–8. https://doi.org/10.2174/1874471011666180502104524.
Article CAS PubMed PubMed Central Google Scholar
Kratochwil C, Bruchertseifer F, Rathke H, Bronzel M, Apostolidis C, Weichert W, et al. Targeted α-Therapy of metastatic Castration-Resistant prostate Cancer with 225Ac-PSMA-617: dosimetry estimate and empiric dose finding. J Nucl Med. 2017;58:1624–31. https://doi.org/10.2967/jnumed.117.191395.
Article CAS PubMed Google Scholar
Poeppel TD, Handkiewicz-Junak D, Andreeff M, Becherer A, Bockisch A, Fricke E, et al. EANM guideline for radionuclide therapy with radium-223 of metastatic castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2018;45:824–45. https://doi.org/10.1007/s00259-017-3900-4.
Article CAS PubMed Google Scholar
Hindorf C, Chittenden S, Aksnes A-K, Parker C, Flux GD. Quantitative imaging of 223Ra-chloride (Alpharadin) for targeted alpha-emitting radionuclide therapy of bone metastases. Nucl Med Commun. 2012;33:726–32. https://doi.org/10.1097/MNM.0b013e328353bb6e.
Article CAS PubMed Google Scholar
Pacilio M, Ventroni G, de Vincentis G, Cassano B, Pellegrini R, Di Castro E, et al. Dosimetry of bone metastases in targeted radionuclide therapy with alpha-emitting (223)Ra-dichloride. Eur J Nucl Med Mol Imaging. 2016;43:21–33. https://doi.org/10.1007/s00259-015-3150-2.
Article CAS PubMed Google Scholar
Ocak M, Toklu T, Demirci E, Selçuk N, Kabasakal L. Post-therapy imaging of 225Ac-DOTATATE treatment in a patient with recurrent neuroendocrine tumor. Eur J Nucl Med Mol Imaging. 2020;47:2711–2. https://doi.org/10.1007/s00259-020-04725-x.
Gosewisch A, Schleske M, Gildehaus FJ, Berg I, Kaiser L, Brosch J, et al. Image-based dosimetry for 225Ac-PSMA-I&T therapy using quantitative SPECT. Eur J Nucl Med Mol Imaging. 2021;48:1260–1. https://doi.org/10.1007/s00259-020-05024-1.
Article CAS PubMed Google Scholar
Delker A, Schleske M, Liubchenko G, Berg I, Zacherl MJ, Brendel M, et al. Biodistribution and dosimetry for combined 177LuLu-PSMA-I&T/225AcAc-PSMA-I&T therapy using multi-isotope quantitative SPECT imaging. Eur J Nucl Med Mol Imaging. 2023;50:1280–90. https://doi.org/10.1007/s00259-022-06092-1.
Article CAS PubMed PubMed Central Google Scholar
Miederer M, Benešová-Schäfer M, Mamat C, Kästner D, Pretze M, Michler E, et al. Alpha-Emitting radionuclides: current status and future perspectives. Pharmaceuticals (Basel). 2024. https://doi.org/10.3390/ph17010076.
Nelson BJB, Wilson J, Andersson JD, Wuest F. Theranostic imaging surrogates for targeted alpha therapy: progress in production, purification, and applications. Pharmaceuticals (Basel). 2023. https://doi.org/10.3390/ph16111622.
Article PubMed PubMed Central Google Scholar
Morgan KA, Rudd SE, Noor A, Donnelly PS. Theranostic nuclear medicine with Gallium-68, Lutetium-177, Copper-64/67, Actinium-225, and Lead-212/203 radionuclides. Chem Rev. 2023;123:12004–35. https://doi.org/10.1021/acs.chemrev.3c00456.
Article CAS PubMed Google Scholar
Meredith R, Torgue J, Shen S, Fisher DR, Banaga E, Bunch P, et al. Dose escalation and dosimetry of first-in-human α radioimmunotherapy with 212Pb-TCMC-trastuzumab. J Nucl Med. 2014;55:1636–42. https://doi.org/10.2967/jnumed.114.143842.
Article CAS PubMed Google Scholar
Meredith RF, Torgue J, Azure MT, Shen S, Saddekni S, Banaga E, et al. Pharmacokinetics and imaging of 212Pb-TCMC-trastuzumab after intraperitoneal administration in ovarian cancer patients. Cancer Biother Radiopharm. 2014;29:12–7. https://doi.org/10.1089/cbr.2013.1531.
Article CAS PubMed PubMed Central Google Scholar
Bauer D, Carter LM, Atmane MI, de Gregorio R, Michel A, Kaminsky S, et al. 212Pb-Pretargeted theranostics for pancreatic Cancer. J Nucl Med. 2023. https://doi.org/10.2967/jnumed.123.266388.
Article PubMed PubMed Central Google Scholar
Chapeau D, Koustoulidou S, Handula M, Beekman S, de Ridder C, Stuurman D, et al. [212Pb]Pb-eSOMA-01: A promising radioligand for targeted alpha therapy of neuroendocrine tumors. Pharmaceuticals. 2023. https://doi.org/10.3390/ph16070985.
Article PubMed PubMed Central Google Scholar
Durand-Panteix S, Monteil J, Sage M, Garot A, Clavel M, Saidi A, et al. Preclinical study of 212Pb alpha-radioimmunotherapy targeting CD20 in non-Hodgkin lymphoma. Br J Cancer. 2021;125:1657–65. https://doi.org/10.1038/s41416-021-01585-6.
Article CAS PubMed PubMed Central Google Scholar
Jiao R, Allen KJH, Malo ME, Yilmaz O, Wilson J, Nelson BJB, et al. A theranostic approach to imaging and treating melanoma with 203Pb/212Pb-Labeled antibody targeting melanin. Cancers (Basel). 2023. https://doi.org/10.3390/cancers15153856.
Article PubMed PubMed Central Google Scholar
Li J, Huang T, Hua J, Wang Q, Su Y, Chen P, et al. CD46 targeted 212Pb alpha particle radioimmunotherapy for prostate cancer treatment. J Exp Clin Cancer Res. 2023;42:61. https://doi.org/10.1186/s13046-023-02636-x.
Article CAS PubMed PubMed Central Google Scholar
Li M, Baumhover NJ, Liu D, Cagle BS, Boschetti F, Paulin G, et al. Preclinical evaluation of a lead specific Chelator (PSC) conjugated to radiopeptides for 203Pb and 212Pb-Based theranostics. Pharmaceutics. 2023. https://doi.org/10.3390/pharmaceutics15020414.
Article PubMed PubMed Central Google Scholar
Lee D, Li M, Liu D, Baumhover NJ, Sagastume EA, Marks BM, et al. Structural modifications toward improved lead-203/lead-212 peptide-based image-guided alpha-particle radiopharmaceutical therapies for neuroendocrine tumors. Eur J Nucl Med Mol Imaging. 2023. https://doi.org/10.1007/s00259-023-06494-9.
Article PubMed PubMed Central Google Scholar
Pretze M, Michler E, Runge R, Wetzig K, Tietze K, Brandt F, et al. Influence of the molar activity of 203/212Pb-PSC-PEG2-TOC on somatostatin receptor type 2-Binding and cell uptake. Pharmaceuticals (Basel). 2023. https://doi.org/10.3390/ph16111605.
Article PubMed PubMed Central Google Scholar
Delpassand ES, Tworowska I, Esfandiari R, Torgue J, Hurt J, Shafie A, Núñez R. Targeted α-Emitter therapy with 212Pb-DOTAMTATE for the treatment of metastatic SSTR-Expressing neuroendocrine tumors: First-in-Humans Dose-Escalation clinical trial. J Nucl Med. 2022;63:1326–33. https://doi.org/10.2967/jnumed.121.263230.
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