Weiskirchen R, Tacke F (2016) Liver fibrosis: from pathogenesis to novel therapies. Dig Dis 34:410–422
Gines P, Krag A, Abraldes JG, Sola E, Fabrellas N, Kamath PS (2021) Liver cirrhosis. Lancet 398:1359–1376
Tsochatzis EA, Bosch J, Burroughs AK (2012) New therapeutic paradigm for patients with cirrhosis. Hepatology 56:1983–1992
Article CAS PubMed Google Scholar
Ratziu V, de Guevara L, Safadi R, Poordad F, Fuster F, Flores-Figueroa J, Arrese M, Fracanzani AL, Ben Bashat D, Lackner K et al (2021) Aramchol in patients with nonalcoholic steatohepatitis: a randomized, double-blind, placebo-controlled phase 2b trial. Nat Med 27:1825–1835
Article CAS PubMed PubMed Central Google Scholar
Ratziu V, Sanyal A, Harrison SA, Wong VW, Francque S, Goodman Z, Aithal GP, Kowdley KV, Seyedkazemi S, Fischer L et al (2020) Cenicriviroc treatment for adults with nonalcoholic steatohepatitis and fibrosis: final analysis of the phase 2b CENTAUR study. Hepatology 72:892–905
Article CAS PubMed Google Scholar
Harrison SA, Abdelmalek MF, Caldwell S, Shiffman ML, Diehl AM, Ghalib R, Lawitz EJ, Rockey DC, Schall RA, Jia C et al (2018) Simtuzumab is ineffective for patients with bridging fibrosis or compensated cirrhosis caused by nonalcoholic steatohepatitis. Gastroenterology 155:1140–1153
Article CAS PubMed Google Scholar
Fallowfield JA, Jimenez-Ramos M, Robertson A (2021) Emerging synthetic drugs for the treatment of liver cirrhosis. Expert Opin Emerg Drugs 26:149–163
Article CAS PubMed Google Scholar
Hammond GL (2016) Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action. J Endocrinol 230:R13-25
Article CAS PubMed PubMed Central Google Scholar
Laurent MR, Hammond GL, Blokland M, Jardi F, Antonio L, Dubois V, Khalil R, Sterk SS, Gielen E, Decallonne B et al (2016) Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis. Sci Rep 6:35539
Article CAS PubMed PubMed Central Google Scholar
Lee SR, Kim NR, Mukae M, Won YS, Hong EJ (2025) Sex hormone-binding globulin dampens growth and metastasis of breast cancer in an estrogen-independent manner. Am J Physiol Cell Physiol 328:C1685–C1698
Lee SR, Lee YH, Yang H, Lee HW, Lee GS, An BS, Jeung EB, Park BK, Hong EJ (2019) Sex hormone-binding globulin suppresses NAFLD-triggered hepatocarcinogenesis after menopause. Carcinogenesis 40:1031–1041
Article CAS PubMed Google Scholar
Saez-Lopez C, Villena JA, Simo R, Selva DM (2020) Sex hormone-binding globulin overexpression protects against high-fat diet-induced obesity in transgenic male mice. J Nutr Biochem 85:108480
Article CAS PubMed Google Scholar
Saez-Lopez C, Salcedo-Allende MT, Hernandez C, Simo-Servat O, Simo R, Selva DM (2019) Sex hormone-binding globulin expression correlates with acetyl-coenzyme A carboxylase and triglyceride content in human liver. J Clin Endocrinol Metab 104:1500–1507
Lee SR, Hong E-J (2021) Sex hormone-binding globulin impedes hepatocellular carcinoma growth via MERTK regulation. Genes & Diseases. https://doi.org/10.1016/j.gendis.2021.10.003
van der Meer JH, van der Poll T, van’t Veer C (2014) TAM receptors, Gas6, and protein S: roles in inflammation and hemostasis. Blood 123:2460–2469
Shi N, Wang Z, Zhu H, Liu W, Zhao M, Jiang X, Zhao J, Ren C, Zhang Y, Luo L (2022) Research progress on drugs targeting the TGF-beta signaling pathway in fibrotic diseases. Immunol Res 70:276–288
Article CAS PubMed PubMed Central Google Scholar
Luangmonkong T, Suriguga S, Bigaeva E, Boersema M, Oosterhuis D, de Jong KP, Schuppan D, Mutsaers HAM, Olinga P (2017) Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. Br J Pharmacol 174:3107–3117
Article CAS PubMed PubMed Central Google Scholar
Zhang J, Li R, Liu Q, Zhou J, Huang H, Huang Y, Zhang Z, Wu T, Tang Q, Huang C et al (2020) SB431542-loaded liposomes alleviate liver fibrosis by suppressing TGF-beta signaling. Mol Pharm 17:4152–4162
Article CAS PubMed Google Scholar
Liu J, Kong D, Qiu J, Xie Y, Lu Z, Zhou C, Liu X, Zhang R, Wang Y (2019) Praziquantel ameliorates CCl4 -induced liver fibrosis in mice by inhibiting TGF-beta/Smad signalling via up-regulating Smad7 in hepatic stellate cells. Br J Pharmacol 176:4666–4680
Article CAS PubMed PubMed Central Google Scholar
Li J, Wang Y, Ma M, Jiang S, Zhang X, Zhang Y, Yang X, Xu C, Tian G, Li Q et al (2019) Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-beta signaling. EBioMedicine 40:43–55
Article CAS PubMed PubMed Central Google Scholar
Hsieh YC, Lee KC, Lei HJ, Lan KH, Huo TI, Lin YT, Chan CC, Schnabl B, Huang YH, Hou MC et al (2021) (Pro)renin receptor knockdown attenuates liver fibrosis through inactivation of ERK/TGF-beta1/SMAD3 pathway. Cell Mol Gastroenterol Hepatol 12:813–838
Article CAS PubMed PubMed Central Google Scholar
Reichl P, Dengler M, van Zijl F, Huber H, Fuhrlinger G, Reichel C, Sieghart W, Peck-Radosavljevic M, Grubinger M, Mikulits W (2015) Axl activates autocrine transforming growth factor-beta signaling in hepatocellular carcinoma. Hepatology 61:930–941
Article CAS PubMed Google Scholar
Landolt L, Furriol J, Babickova J, Ahmed L, Eikrem O, Skogstrand T, Scherer A, Suliman S, Leh S, Lorens JB et al (2019) AXL targeting reduces fibrosis development in experimental unilateral ureteral obstruction. Physiol Rep 7:e14091
Article PubMed PubMed Central Google Scholar
Tutusaus A, de Gregorio E, Cucarull B, Cristobal H, Areste C, Graupera I, Coll M, Colell A, Gausdal G, Lorens JB et al (2020) A functional role of GAS6/TAM in nonalcoholic steatohepatitis progression implicates AXL as therapeutic target. Cell Mol Gastroenterol Hepatol 9:349–368
Barcena C, Stefanovic M, Tutusaus A, Joannas L, Menendez A, Garcia-Ruiz C, Sancho-Bru P, Mari M, Caballeria J, Rothlin CV et al (2015) Gas6/Axl pathway is activated in chronic liver disease and its targeting reduces fibrosis via hepatic stellate cell inactivation. J Hepatol 63:670–678
Article CAS PubMed PubMed Central Google Scholar
Janne M, Hogeveen KN, Deol HK, Hammond GL (1999) Expression and regulation of human sex hormone-binding globulin transgenes in mice during development. Endocrinology 140:4166–4174
Article CAS PubMed Google Scholar
Janne M, Deol HK, Power SG, Yee SP, Hammond GL (1998) Human sex hormone-binding globulin gene expression in transgenic mice. Mol Endocrinol 12:123–136
Article CAS PubMed Google Scholar
Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G et al (2019) Enhancer of zeste homologue 2 inhibition attenuates TGF-beta dependent hepatic stellate cell activation and liver fibrosis. Cell Mol Gastroenterol Hepatol 7:197–209
Huang F, Chen YG (2012) Regulation of TGF-beta receptor activity. Cell Biosci 2:9
Article CAS PubMed PubMed Central Google Scholar
Colak S, Ten Dijke P (2017) Targeting TGF-beta signaling in cancer. Trends in cancer 3:56–71
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