Wong VW, Ekstedt M, Wong GL, Hagström H (2023) Changing epidemiology, global trends and implications for outcomes of NAFLD. J Hepatol 79(3):842–852
Powell EE, Wong VW, Rinella M (2021) Non-alcoholic fatty liver disease. Lancet 397(10290):2212–2224
Article CAS PubMed Google Scholar
Huby T, Gautier EL (2022) Immune cell-mediated features of non-alcoholic steatohepatitis. Nat Rev Immunol 22(7):429–443
Article CAS PubMed Google Scholar
Hammerich L, Tacke F (2023) Hepatic inflammatory responses in liver fibrosis. Nat Rev Gastroenterol Hepatol 20(10):633–646
Article CAS PubMed Google Scholar
Kisseleva T, Brenner D (2021) Molecular and cellular mechanisms of liver fibrosis and its regression. Nat Rev Gastroenterol Hepatol 18(3):151–166
Harrison SA, Allen AM, Dubourg J, Noureddin M, Alkhouri N (2023) Challenges and opportunities in NASH drug development. Nat Med 29(3):562–573
Article CAS PubMed Google Scholar
Keam SJ (2024) Resmetirom: first approval. Drugs 84(6):729–735
Article CAS PubMed Google Scholar
Friedman SL, Neuschwander-Tetri BA, Rinella M, Sanyal AJ (2018) Mechanisms of NAFLD development and therapeutic strategies. Nat Med 24(7):908–922
Article CAS PubMed PubMed Central Google Scholar
Hopfner KP, Hornung V (2020) Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol Cell Biol 21(9):501–521
Article CAS PubMed Google Scholar
Dvorkin S, Cambier S, Volkman HE, Stetson DB (2024) New frontiers in the cGAS-STING intracellular DNA-sensing pathway. Immunity 57(4):718–730
Article CAS PubMed PubMed Central Google Scholar
Yang N, Sun S, Xu J, Gong F, Lei H, Hao Y, Pei Z, Wang C, Yu Q, Nie J, et al (2025) Manganese galvanic cells intervene in tumor metabolism to reinforce cGAS-STING activation for bidirectional synergistic hydrogen-immunotherapy. Adv Mater 37(8):e2414929. https://doi.org/10.1002/adma.202414929
Cheng L, Fang Z, Wang J, Xi K, Zhang Y, Feng F, Yu L, Santiago M, Wang J, Wu Z et al (2025) Mitochondrial inflexibility ignites tumor immunogenicity in postoperative glioblastoma. Nat Commun 16(1):6946
Article CAS PubMed PubMed Central Google Scholar
Li W, Li Y, Kang J, Jiang H, Gong W, Chen L, Wu C, Liu M, Wu X, Zhao Y (2023) 4-octyl itaconate as a metabolite derivative inhibits inflammation via alkylation of STING. Cell Rep 42(3):112145. https://doi.org/10.1016/j.celrep.2023.112145
Article CAS PubMed Google Scholar
Ma X, Chen A, Melo L, Clemente-Sanchez A, Chao X, Ahmadi AR, Peiffer B, Sun Z, Sesaki H, Li T et al (2023) Loss of hepatic DRP1 exacerbates alcoholic hepatitis by inducing megamitochondria and mitochondrial maladaptation. Hepatology 77(1):159–175
Wei B, Xu L, Guo W, Wang Y, Wu J, Li X, Cai X, Hu J, Wang M, Xu Q et al (2021) SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer. Cancer Res 81(12):3215–28. https://doi.org/10.1158/0008-5472.Can-20-3738
Morandi F, Horenstein AL, Malavasi F (2021) The key role of NAD(+) in anti-tumor immune response: an update. Front Immunol 12:658263
Article CAS PubMed PubMed Central Google Scholar
Vinuesa CG, Grenov A, Kassiotis G (2023) Innate virus-sensing pathways in B cell systemic autoimmunity. Science 380(6644):478–484
Article CAS PubMed Google Scholar
Skopelja-Gardner S, An J, Elkon KB (2022) Role of the cGAS-STING pathway in systemic and organ-specific diseases. Nat Rev Nephrol 18(9):558–572
Article CAS PubMed PubMed Central Google Scholar
Wu Q, Leng X, Zhang Q, Zhu YZ, Zhou R, Liu Y, Mei C, Zhang D, Liu S, Chen S et al (2024) IRF3 activates RB to authorize cGAS-STING-induced senescence and mitigate liver fibrosis. Sci Adv 10(9):eadj2102. https://doi.org/10.1126/sciadv.adj2102
Article CAS PubMed PubMed Central Google Scholar
Baccala R, Gonzalez-Quintial R, Lawson BR, Stern ME, Kono DH, Beutler B, Theofilopoulos AN (2009) Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol 5(8):448–456
Article CAS PubMed Google Scholar
Wein T, Sorek R (2022) Bacterial origins of human cell-autonomous innate immune mechanisms. Nat Rev Immunol 22(10):629–638
Article CAS PubMed Google Scholar
Chen Q, Sun L, Chen ZJ (2016) Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat Immunol 17(10):1142–1149
Article CAS PubMed Google Scholar
An H, Hou J, Zhou J, Zhao W, Xu H, Zheng Y, Yu Y, Liu S, Cao X (2008) Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat Immunol 9(5):542–550
Article CAS PubMed Google Scholar
Xiao Y, Zhao C, Tai Y, Li B, Lan T, Lai E, Dai W, Guo Y, Gan C, Kostallari E et al (2023) STING mediates hepatocyte pyroptosis in liver fibrosis by epigenetically activating the NLRP3 inflammasome. Redox Biol 62:102691. https://doi.org/10.1016/j.redox.2023.102691
Article CAS PubMed PubMed Central Google Scholar
Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, et al. STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity. 2014;41(5):830–42. Epub 2014/12/18. https://doi.org/10.1016/j.immuni.2014.10.017.
Hu Y, Chen BJ, Yang F, Su Y, Yang DS, Yao Y, Wang SX, Wu YC, Tao LS, Xu T (2022) Emerging role of the cGAS-STING signaling pathway in autoimmune diseases: biologic function, mechanisms and clinical prospection. Autoimmun Rev. https://doi.org/10.1016/j.autrev.2022.103155
Oduro PK, Zheng XX, Wei JN, Yang YZ, Wang YF, Zhang H, Liu EW, Gao XM, Du M, Wang QL (2022) The cGAS-STING signaling in cardiovascular and metabolic diseases: future novel target option for pharmacotherapy. Acta Pharm Sin B 12(1):50–75
Article CAS PubMed Google Scholar
Sun Z, Hornung V (2022) cGAS-STING signaling. Curr Biol 32(13):R730–R734
Chen C, Xu P (2023) Cellular functions of cGAS-STING signaling. Trends Cell Biol 33(8):630–648
Article CAS PubMed Google Scholar
Zhong W, Rao Z, Xu J, Sun Y, Hu H, Wang P, Xia Y, Pan X, Tang W, Chen Z et al (2022) Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation. Aging Cell 21(6):e13622
Article CAS PubMed PubMed Central Google Scholar
Pan J, Fei CJ, Hu Y, Wu XY, Nie L, Chen J (2023) Current understanding of the cGAS-STING signaling pathway: structure, regulatory mechanisms, and related diseases. Zool Res 44(1):183–218
Article CAS PubMed PubMed Central Google Scholar
Ergun SL, Li L (2020) Structural insights into STING signaling. Trends Cell Biol 30(5):399–407
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