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cGAS-STING signaling pathway in MASLD and liver fibrosis
cGAS-STING signaling pathway in MASLD and liver fibrosis
In metabolic dysfunction-associated steatotic liver disease (MASLD), lipid accumulation and inflammatory stimulation lead ...
E2F7 targets S100A2 to suppress CD8T cell activity in lung adenocarcinoma by regulating glutamine metabolism
E2F7 targets S100A2 to suppress CD8T cell activity in lung adenocarcinoma by regulating glutamine metabolism
Malignant cells within the tumor microenvironment have developed numerous strategies to resist the CD8+T cell-driven immun...
Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK
Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK
Acute myeloid leukaemia with normal karyotype (AML-NK) is a cytogenetically cryptic yet heterogeneous clinical subgroup th...
Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis
Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis
OCCC has extremely poor prognosis. ARID1A mutation-related chromatin remodeling errors are key molecular features of OCCC....
Alcohol induces sorafenib resistance in hepatocellular carcinoma: A translational study
Alcohol induces sorafenib resistance in hepatocellular carcinoma: A translational study
Alcohol is a major cause of hepatocellular carcinoma (HCC), accounting for 30% of cases worldwide. Sorafenib, a tyrosine k...
Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells
Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells
ERK activity governs diverse cellular responses and has significant implications in cancer biology and treatment. Cellular...
DAPL1 is activated by Np63 and GRα and regulates lipid metabolism
DAPL1 is activated by Np63 and GRα and regulates lipid metabolism
Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancer occurrences and is divided into largely Adeno...
Prosaposin in CNS health and disease, metabolic stress and exercise adaptation
Prosaposin in CNS health and disease, metabolic stress and exercise adaptation
Prosaposin (PSAP), a highly conserved lysosomal protein and precursor of saposins A–D, has emerged as a key regulato...
Liver specific-inhibition of LPCAT3 ameliorates metabolic dysfunction-associated steatotic liver disease
Liver specific-inhibition of LPCAT3 ameliorates metabolic dysfunction-associated steatotic liver disease
The membrane unsaturation in the liver is associated with abnormal biosynthesis and accumulation of cholesterol and trigly...
Integrated regulation of ferroptosis in prostate cancer covering mechanisms, resistance, and translational opportunities
Integrated regulation of ferroptosis in prostate cancer covering mechanisms, resistance, and translational opportunities
Ferroptosis, an iron dependent form of regulated cell death driven by lipid peroxidation, has emerged as a pivotal process...
Spinal fluid antibody profile against bacteria demonstrates intrathecal antibody production in demyelinating diseases
Spinal fluid antibody profile against bacteria demonstrates intrathecal antibody production in demyelinating diseases
This study follows work establishing multiple sclerosis (MS) microbial candidates from RNA sequencing of human brain sampl...
Galectin-9 potentiates salivary gland damage by inducing ferroptosis in Sjogren’s disease
Galectin-9 potentiates salivary gland damage by inducing ferroptosis in Sjogren’s disease
Sjögren’s disease (SjD), a systemic autoimmune disease, is characterized by exocrine glandular damage and hypof...
Bystander effects in photodynamic therapy-treated tumors involve spatiotemporally extended ferroptosis
Bystander effects in photodynamic therapy-treated tumors involve spatiotemporally extended ferroptosis
The tumor bystander effect describes the ability of cells sustaining therapeutic treatment damage to transmit distress sig...
TFR2 p.A75V mutation aggravates liver iron overload in alcoholic liver disease via ERK pathway
TFR2 p.A75V mutation aggravates liver iron overload in alcoholic liver disease via ERK pathway
Liver iron overload, a contributing factor to liver damage, is frequently observed in advanced alcoholic liver disease (AL...
Anti-myeloma activity of the CXCR4 antagonist WZ811
Anti-myeloma activity of the CXCR4 antagonist WZ811
The CXCR4-CXCL12 axis is crucial for the interaction between malignant plasma cells (PC) and their microenvironment in mul...
Lipids in kidney diseases: from systemic imbalance to intrarenal alterations of cellular lipid metabolism in rare and common kidney diseases
Lipids in kidney diseases: from systemic imbalance to intrarenal alterations of cellular lipid metabolism in rare and common kidney diseases
Chronic kidney disease (CKD) is expected to be the fifth cause of global mortality by 2040. Modifiable and non-modifiable ...
Piezo1/PI3K-induced autophagy dysregulation in PDLSCs under mechanical stress during root resorption
Piezo1/PI3K-induced autophagy dysregulation in PDLSCs under mechanical stress during root resorption
This study aimed to clarify the mechanobiological mechanisms of physiological root resorption in deciduous teeth, focusing...
Genetic analysis and reporting from whole-exome sequencing data in 1052 patients with intellectual disability
Genetic analysis and reporting from whole-exome sequencing data in 1052 patients with intellectual disability
Intellectual disability (ID) is a genetically heterogeneous neurodevelopmental disorder, with etiological diagnosis remain...
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways
Myeloid differentiation protein 2 (MD2), a co-receptor of toll-like receptor 4 (TLR4) in the innate immune system, has eme...
The role of innate immunity triggered by HPV infection in promoting cervical lesions
The role of innate immunity triggered by HPV infection in promoting cervical lesions
Innate immunity is the immune system that organisms possess from birth. It is primarily responsible for the rapid, nonspec...
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
Metformin is a commonly prescribed antidiabetic drug that inhibits hepatic glucose production (HGP). Recent studies examin...
Tumor hypoxia shapes natural killer cell anticancer activities
Tumor hypoxia shapes natural killer cell anticancer activities
Tumor hypoxia, a hallmark of the tumor microenvironment (TME), profoundly impacts the antitumor functionality of immune ce...
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation
Ferroptosis has been closely linked to the pathological processes of various diseases, making it a promising target for th...
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
The TNF family member LIGHT (TNFSF14) binds to two receptors, HVEM (TNFSFR14) and LTβR (TNFSFR3). HVEM functions as a...
MicroRNA-100-5p in exosomes from human placental mesenchymal stem cells: a key modulator of anti-psoriatic effects through mTOR/S6 K1 pathway
MicroRNA-100-5p in exosomes from human placental mesenchymal stem cells: a key modulator of anti-psoriatic effects through mTOR/S6 K1 pathway
Exosomes from mesenchymal stem cells (MSCs) demonstrate therapeutic potential against psoriasis, primarily due to their an...
Specialized pro-resolving mediators: key regulators in placental function and pregnancy complications
Specialized pro-resolving mediators: key regulators in placental function and pregnancy complications
Specialized pro-resolving mediators (SPMs) are bioactive lipids derived from essential fatty acids that play a key role in...
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Molecular biomarkers are valuable tools to predict the disease and determine its course. Several markers have been associa...
PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential
PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential
Poly(rC)-Binding Protein 2 (PCBP2) stands as a pivotal component within the PCBP family, renowned for its multifaceted rol...
Impact of frameshift extension variant on auditory function and development
Impact of frameshift extension variant on auditory function and development
The HOMER2 gene, crucial for synaptic signaling and calcium homeostasis in the auditory system, is linked to sensorineural...
Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
The interplay between selenium (Se) metabolism and ferroptosis presents a compelling area of study in cancer biology. This...
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