van Leeuwen LPM, de Jong W, Doornekamp L, van Gorp ECM, Wismans PJ, Goeijenbier M. Exotic viral hepatitis: a review on epidemiology, pathogenesis, and treatment. J Hepatol. 2022;77(5):1431–43.
Asrani SK, Devarbhavi H, Eaton J, Kamath PS. Burden of liver diseases in the world. J Hepatol. 2019;70(1):151–71.
Ayyala-Somayajula D, Dodge JL, Farias A, Terrault N, Lee BP. Healthcare affordability and effects on mortality among adults with liver disease from 2004 to 2018 in the United States. J Hepatol. 2023;79(2):329–39.
Torre E, Di Matteo S, Martinotti C, Bruno GM, Goglia U, Testino G, Rebora A, Bottaro LC, Colombo GL. Economic impact of metabolic dysfunction-associated steatotic liver disease (MAFLD) in Italy. Analysis and perspectives. Clinicoecon Outcomes Res. 2024;16:773–84.
Lazarus JV, Mark HE, Anstee QM, Arab JP, Batterham RL, Castera L, Cortez-Pinto H, Crespo J, Cusi K, Dirac MA, et al. Advancing the global public health agenda for NAFLD: a consensus statement. Nat Rev Gastroenterol Hepatol. 2022;19(1):60–78.
Ma C, Qian AS, Nguyen NH, Stukalin I, Congly SE, Shaheen AA, Swain MG, Teriaky A, Asrani SK, Singh S. Trends in the economic burden of chronic liver diseases and cirrhosis in the United States: 1996–2016. Am J Gastroenterol. 2021;116(10):2060–7.
Rinella ME, Lazarus JV, Ratziu V, Francque SM, Sanyal AJ, Kanwal F, Romero D, Abdelmalek MF, Anstee QM, Arab JP, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966–86.
Younossi ZM, Wong G, Anstee QM, Henry L. The global burden of liver disease. Clin Gastroenterol Hepatol. 2023;21(8):1978–91.
Li W, Kemos P, Salciccioli JD, Marshall DC, Shalhoub J, Alazawi W: Socioeconomic factors associated with liver-related mortality from 1985 to 2015 in 36 developed countries. Clin Gastroenterol Hepatol 2021, 19(8).
McWhinney SR, Hlinka J, Bakstein E, Dietze LMF, Corkum ELV, Abé C, Alda M, Alexander N, Benedetti F, Berk M, et al. Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders-ENIGMA study in people with bipolar disorders and obesity. Hum Brain Mapp. 2024;45(8): e26682.
Kjærgaard K, Mikkelsen ACD, Wernberg CW, Grønkjær LL, Eriksen PL, Damholdt MF, Mookerjee RP, Vilstrup H, Lauridsen MM, Thomsen KL: Cognitive dysfunction in non-alcoholic fatty liver disease-current knowledge, mechanisms and perspectives. J Clin Med 2021, 10(4).
Seo SW, Gottesman RF, Clark JM, Hernaez R, Chang Y, Kim C, Ha KH, Guallar E, Lazo M. Nonalcoholic fatty liver disease is associated with cognitive function in adults. Neurology. 2016;86(12):1136–42.
Giuffrè M, Merli N, Pugliatti M, Moretti R. The metabolic impact of nonalcoholic fatty liver disease on cognitive dysfunction: a comprehensive clinical and pathophysiological review. Int J Mol Sci. 2024;25(6):3337.
Hjerrild S, Renvillard SG, Leutscher P, Sørensen LH, Østergaard L, Eskildsen SF, Videbech P. Reduced cerebral cortical thickness in Non-cirrhotic patients with hepatitis C. Metab Brain Dis. 2016;31(2):311–9.
Marino JS, Stechschulte LA, Stec DE, Nestor-Kalinoski A, Coleman S, Hinds TD. Glucocorticoid receptor β induces hepatic steatosis by augmenting inflammation and inhibition of the peroxisome proliferator-activated receptor (PPAR) α. J Biol Chem. 2016;291(50):25776–88.
Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KSL, Xu A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes. 2014;63(12):4064–75.
Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol. 2013;37(7):658–65.
Mai Z, Mao H. Causal effects of nonalcoholic fatty liver disease on cerebral cortical structure: a Mendelian randomization analysis. Front Endocrinol (Lausanne). 2023;14:1276576.
Lin Y-K, Cai X-R, Chen J-Z, Hong H-J, Tu K, Chen Y-L, Du Q. Non-alcoholic fatty liver disease causally affects the brain cortical structure: a Mendelian randomization study. Front Neurosci. 2023;17:1305624.
Grasby KL, Jahanshad N, Painter JN, Colodro-Conde L, Bralten J, Hibar DP, Lind PA, Pizzagalli F, Ching CRK, McMahon MAB, et al. The genetic architecture of the human cerebral cortex. Science. 2020;367:6484.
Desikan RS, Ségonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT, et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006;31(3):968–80.
Kurki MI, Karjalainen J, Palta P, Sipilä TP, Kristiansson K, Donner KM, Reeve MP, Laivuori H, Aavikko M, Kaunisto MA, et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature. 2023;613(7944):508–18.
de Leeuw C, Savage J, Bucur IG, Heskes T, Posthuma D. Understanding the assumptions underlying Mendelian randomization. Eur J Hum Genet. 2022;30(6):653–60.
Chen L, Fang M-J, Yu X-E, Xu Y. Genetic analyses identify brain functional networks associated with the risk of Parkinson’s disease and drug-induced parkinsonism. Cereb Cortex. 2025. https://doi.org/10.1093/cercor/bhae506.
Teng F, Wang M, Lu Z, Zhang C, Xiao L, Chen Z, Huang M, Xie L, Chen Z, Wang W. Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization. Cereb Cortex. 2024. https://doi.org/10.1093/cercor/bhae440.
Burgess S, Thompson SG. Avoiding bias from weak instruments in Mendelian randomization studies. Int J Epidemiol. 2011;40(3):755–64.
Verbanck M, Chen C-Y, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet. 2018;50(5):693–8.
Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015;44(2):512–25.
Bowden J, Davey Smith G, Haycock PC, Burgess S. Consistent estimation in mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol. 2016;40(4):304–14.
Meisinger C, Fischer S, O’Mara T, Freuer D. Two-sample Mendelian Randomization to evaluate the causal relationship between inflammatory arthritis and female-specific cancers. J Transl Med. 2024;22(1):962.
Salim S. Oxidative stress: a potential link between emotional wellbeing and immune response. Curr Opin Pharmacol. 2016;29:70–6.
Journée SH, Mathis VP, Fillinger C, Veinante P, Yalcin I. Janus effect of the anterior cingulate cortex: pain and emotion. Neurosci Biobehav Rev. 2023;153: 105362.
Ninkov M, Rudak PT, Wang NI, Rashu R, Inoue W, Haeryfar SMM: Psychological stress triggers the accumulation of myeloid-derived suppressor cells in the liver through adrenergic receptor signaling. J Immunol 2023, 210(Supplement 1):167.113–167.113.
Petrie KJ, Booth RJ, Pennebaker JW, Davison KP, Thomas MG. Disclosure of trauma and immune response to a hepatitis B vaccination program. J Consult Clin Psychol. 1995;63(5):787–92.
Hosman T, Hynes JB, Saab J, Wilcoxen KG, Buchbinder BR, Schmansky N, Cash SS, Eskandar EN, Simeral JD, Franco B, et al. Auditory cues reveal intended movement information in middle frontal gyrus neuronal ensemble activity of a person with tetraplegia. Sci Rep. 2021;11(1):98.
Strick PL, Dum RP, Rathelot J-A. The cortical motor areas and the emergence of motor skills: a neuroanatomical perspective. Annu Rev Neurosci. 2021;44:425–47.
Thyfault JP, Bergouignan A. Exercise and metabolic health: beyond skeletal muscle. Diabetologia. 2020;63(8):1464–74.
Peng K, Steele SC, Becerra L, Borsook D. Brodmann area 10: Collating, integrating and high level processing of nociception and pain. Prog Neurobiol. 2018;161:1–22.
Sayette MA. The effects of alcohol on emotion in social drinkers. Behav Res Ther. 2017;88:76–89.
Wu X, Fan X, Miyata T, Kim A, Cajigas-Du Ross CK, Ray S, Huang E, Taiwo M, Arya R, Wu J, et al. Recent advances in understanding of pathogenesis of alcohol-associated liver disease. Annu Rev Pathol. 2023;18:411–38.
Igarashi KM. Entorhinal cortex dysfunction in Alzheimer’s disease. Trends Neurosci. 2023;46(2):124–36.
Shea S, Lionis C, Kite C, Atkinson L, Chaggar SS, Randeva HS, Kyrou I. Non-alcoholic fatty liver disease (NAFLD) and potential links to depression, anxiety, and chronic stress. Biomedicines. 2021;9(11):1697.
Beydoun MA, Canas JA. nonalcoholic fatty liver disease: does this metabolic condition have brain function sequelae? Neurology. 2022;99(6):225–6.
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