Kettenmann H, Hanisch UK, Noda M, Verkhratsky A. Physiology of microglia. Physiol Rev 2011, 91: 461–553.

CAS  PubMed  Google Scholar 

Hanisch UK, Kettenmann H. Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 2007, 10: 1387–1394.

CAS  PubMed  Google Scholar 

Lv Z, Chen L, Chen P, Peng H, Rong Y, Hong W. Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective. Neuron 2024, 112: 740-754.e7.

CAS  PubMed  Google Scholar 

Wolf SA, Boddeke HM, Kettenmann H. Microglia in physiology and disease. Annu Rev Physiol 2017, 79: 619–643.

CAS  PubMed  Google Scholar 

Peng HR, Zhang YK, Zhou JW. The structure and function of glial networks: Beyond the neuronal connections. Neurosci Bull 2023, 39: 531–540.

PubMed  Google Scholar 

Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, et al. Alzheimer’s disease. Lancet 2021, 397: 1577–1590.

CAS  PubMed  PubMed Central  Google Scholar 

Edler MK, Mhatre-Winters I, Richardson JR. Microglia in aging and Alzheimer’s disease: A comparative species review. Cells 2021, 10: 1138.

CAS  PubMed  PubMed Central  Google Scholar 

Berridge MJ. Calcium hypothesis of Alzheimer’s disease. Pflugers Arch 2010, 459: 441–449.

CAS  PubMed  Google Scholar 

Mattson MP. ER calcium and Alzheimer’s disease: In a state of flux. Sci Signal 2010, 3: pe10.

Groten CJ, MacVicar BA. Mitochondrial Ca2+ uptake by the MCU facilitates pyramidal neuron excitability and metabolism during action potential firing. Commun Biol 2022, 5: 900.

CAS  PubMed  PubMed Central  Google Scholar 

Brawek B, Schwendele B, Riester K, Kohsaka S, Lerdkrai C, Liang Y, et al. Impairment of in vivo calcium signaling in amyloid plaque-associated microglia. Acta Neuropathol 2014, 127: 495–505.

CAS  PubMed  Google Scholar 

Sieger D, Moritz C, Ziegenhals T, Prykhozhij S, Peri F. Long-range Ca2+ waves transmit brain-damage signals to microglia. Dev Cell 2012, 22: 1138–1148.

CAS  PubMed  Google Scholar 

Pozner A, Xu B, Palumbos S, Michael Gee J, Tvrdik P, Capecchi MR. Intracellular calcium dynamics in cortical microglia responding to focal laser injury in the PC: : G5-tdT reporter mouse. Front Mol Neurosci 2015, 8: 12.

PubMed  PubMed Central  Google Scholar 

Eichhoff G, Brawek B, Garaschuk O. Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo. Biochim Biophys Acta 2011, 1813: 1014–1024.

CAS  PubMed  Google Scholar 

Dong Y, Tang L. Microglial calcium homeostasis modulator 2: Novel anti-neuroinflammation target for the treatment of neurodegenerative diseases. Neurosci Bull 2024, 40: 553–556.

PubMed  Google Scholar 

Hoffmann A, Kann O, Ohlemeyer C, Hanisch UK, Kettenmann H. Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): Suppression of receptor-evoked calcium signaling and control of release function. J Neurosci 2003, 23: 4410–4419.

CAS  PubMed  PubMed Central  Google Scholar 

Umpierre AD, Wu LJ. How microglia sense and regulate neuronal activity. Glia 2021, 69: 1637–1653.

CAS  PubMed  Google Scholar 

Möller T. Calcium signaling in microglial cells. Glia 2002, 40: 184–194.

PubMed  Google Scholar 

Brawek B, Garaschuk O. Microglial calcium signaling in the adult, aged and diseased brain. Cell Calcium 2013, 53: 159–169.

CAS  PubMed  Google Scholar 

Del Prete D, Checler F, Chami M. Ryanodine receptors: Physiological function and deregulation in Alzheimer disease. Mol Neurodegener 2014, 9: 21.

PubMed  PubMed Central  Google Scholar 

Mustaly-Kalimi S, Gallegos W, Marr RA, Gilman-Sachs A, Peterson DA, Sekler I, et al. Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer’s disease. Proc Natl Acad Sci U S A 2022, 119: e2211999119.

CAS  PubMed  PubMed Central  Google Scholar 

Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, et al. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer’s disease mutations: Potential factors in amyloid plaque formation. J Neurosci 2006, 26: 10129–10140.

CAS  PubMed  PubMed Central  Google Scholar 

Hickman S, Izzy S, Sen P, Morsett L, El Khoury J. Microglia in neurodegeneration. Nat Neurosci 2018, 21: 1359–1369.

CAS  PubMed  PubMed Central  Google Scholar 

Cardona AE, Huang D, Sasse ME, Ransohoff RM. Isolation of murine microglial cells for RNA analysis or flow cytometry. Nat Protoc 2006, 1: 1947–1951.

CAS  PubMed  Google Scholar 

Keren-Shaul H, Spinrad A, Weiner A, Matcovitch-Natan O, Dvir-Szternfeld R, Ulland TK, et al. A unique microglia type associated with restricting development of Alzheimer’s disease. Cell 2017, 169: 1276-1290.e17.

CAS  PubMed  Google Scholar 

Zhou Y, Song WM, Andhey PS, Swain A, Levy T, Miller KR, et al. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease. Nat Med 2020, 26: 131–142.

CAS  PubMed  PubMed Central  Google Scholar 

Fatmi MK, Wang H, Slotabec L, Wen C, Seale B, Zhao B, et al. Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer’s disease by activated protein C. Aging (Albany NY) 2024, 16: 3137–3159.

CAS  PubMed  Google Scholar 

Madry C, Kyrargyri V, Lorena Arancibia-Cárcamo I, Jolivet R, Kohsaka S, Bryan RM, et al. Microglial ramification, surveillance, and interleukin-1β release are regulated by the two-pore domain K+ channel THIK-1. Neuron 2018, 97: 299-312.e6.

CAS  PubMed  PubMed Central  Google Scholar 

Nath T, Mathis A, Chen AC, Patel A, Bethge M, Mathis MW. Using DeepLabCut for 3D markerless pose estimation across species and behaviors. Nat Protoc 2019, 14: 2152–2176.

CAS  PubMed  Google Scholar 

Lian H, Roy E, Zheng H. Microglial phagocytosis assay. Bio Protoc 2016, 6: e1988.

PubMed  Google Scholar 

Berridge MJ, Bootman MD, Llewelyn Roderick H. Calcium signalling: Dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 2003, 4: 517–529.

CAS  PubMed  Google Scholar 

Putney JW, Steinckwich-Besançon N, Numaga-Tomita T, Davis FM, Desai PN, D’Agostin DM, et al. The functions of store-operated calcium channels. Biochim Biophys Acta Mol Cell Res 2017, 1864: 900–906.

CAS  PubMed  Google Scholar 

Liu X, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Chen BX, et al. Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell 2012, 150: 1055–1067.

CAS  PubMed  PubMed Central  Google Scholar 

Ouyang Y, Wen L, Armstrong JA, Chvanov M, Latawiec D, Cai W, et al. Protective effects of necrostatin-1 in acute pancreatitis: Partial involvement of receptor interacting protein kinase 1. Cells 2021, 10: 1035.

CAS  PubMed  PubMed Central  Google Scholar 

Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, et al. Inhibitors of ORAI1 prevent cytosolic calcium-associated injury of human pancreatic acinar cells and acute pancreatitis in 3 mouse models. Gastroenterology 2015, 149: 481-492.e7.

CAS  PubMed  Google Scholar 

Jacobson KA, Gao ZG, Matricon P, Eddy MT, Carlsson J. Adenosine A2A receptor antagonists: From caffeine to selective non-xanthines. Br J Pharmacol 2022, 179: 3496–3511.

CAS  PubMed  Google Scholar 

Hansen DV, Hanson JE, Sheng M. Microglia in Alzheimer’s disease. J Cell Biol 2018, 217: 459–472.

CAS  PubMed  PubMed Central  Google Scholar 

Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, et al. Microglia states and nomenclature: A field at its crossroads. Neuron 2022, 110: 3458–3483.

CAS