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A Comprehensive Study of AAV Tropism in the Marmoset Brain
A Comprehensive Study of AAV Tropism in the Marmoset Brain
The common marmoset has emerged as an increasingly valuable non-human primate model in neuroscience and biomedical researc...
Kainate Receptors in Sensory Neurons: Molecular Identity and Functional Relevance to Pain
Kainate Receptors in Sensory Neurons: Molecular Identity and Functional Relevance to Pain
Kainate receptors (KARs) are members of the ionotropic glutamate receptor family and possess diverse structural and functi...
Unconscious Fear Requires Attention to Distort Vision in Safe Context
Unconscious Fear Requires Attention to Distort Vision in Safe Context
Despite widespread exposure to stress and threats, why some develop anxiety while others do not remains unclear. We hypoth...
Distinct Role of Specialized Cutaneous Schwann Cell Network in Acute and Chronic Pain Sensation
Distinct Role of Specialized Cutaneous Schwann Cell Network in Acute and Chronic Pain Sensation
Specialized cutaneous Schwann cells (scSCs) are a recently identified glial class implicated in cutaneous pain modulation,...
Aging-Related Changes in the Injury Response of the Peripheral Nervous System
Aging-Related Changes in the Injury Response of the Peripheral Nervous System
Peripheral nerve injury (PNI) significantly impairs patients’ quality of life, with elderly individuals experiencing...
Ca-Independent Exocytosis Favors Axonal Release through Enlarged Fusion Pores in Sensory Neurons
Ca-Independent Exocytosis Favors Axonal Release through Enlarged Fusion Pores in Sensory Neurons
While Katz’s Ca2+ hypothesis has defined that action potentials trigger neurotransmitter release through Ca2+-depend...
Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease
Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease
White matter, constituting nearly half of the human brain, is increasingly recognized as a dynamic regulator of neural com...
Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway
Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway
Endoplasmic reticulum (ER) stress plays a significant role in chronic pain, but its potential involvement in chronic itch ...
Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout
Tissue-Resident Macrophage PIEZO1 Transduces Mechanical Stress into Inflammatory Pain in Acute Gout
Gouty arthritis is an autoinflammatory joint disease caused by the deposition of monosodium urate crystals, which activate...
Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia
Microglia Pyroptosis-Derived IL-18 Drives White Matter Injury in Developing Brain following Hypothermic Hypoxia-Ischemia
Hypothermia is widely acknowledged to exert protective effects against cerebral hypoxic-ischemic injury. Despite ...
Acoustic Flutter Processing in the Inferior Colliculus of Awake Marmosets: Complementary Rate Coding Modulated by Acoustic Parameters
Acoustic Flutter Processing in the Inferior Colliculus of Awake Marmosets: Complementary Rate Coding Modulated by Acoustic Parameters
The acoustic flutter is processed through complementary monotonic rate coding and cannot be modulated by other acoustic pa...
Astrocyte-Specific Upregulation of Tumor Necrosis Factor Receptor II Ameliorates Pathological Phenotypes in APP Mice
Astrocyte-Specific Upregulation of Tumor Necrosis Factor Receptor II Ameliorates Pathological Phenotypes in APP Mice
Our earlier research showed that deletion of tumor necrosis factor-α receptor II (TNFRII) exacerbated Alzheimer’...
Preparatory Activity Indexes Motor Memory in the Motor Cortex
Preparatory Activity Indexes Motor Memory in the Motor Cortex
Churchland MM, Cunningham JP, Kaufman MT, Ryu SI, Shenoy KV. Cortical preparatory activity: Representation of movement or ...
Hyoscyamine Ameliorates Repetitive Behavior in NLG1 and SHANK3 Deficient-Mice
Hyoscyamine Ameliorates Repetitive Behavior in NLG1 and SHANK3 Deficient-Mice
Tanguay PE. Autism in DSM-5. Am J Psychiatry 2011, 168: 1142–1144.Article  PubMed  Google Sch...
Electrochemical Detection of Oxytocin: Challenges and Prospects
Electrochemical Detection of Oxytocin: Challenges and Prospects
Cui X, Xiao L. Complexity of the hypothalamic oxytocin system and its involvement in brain functions and diseases. Neurosc...
A Genetically Defined Thalamic Circuit Encodes Social Touch
A Genetically Defined Thalamic Circuit Encodes Social Touch
Tamè L, Longo MR. Emerging principles in functional representations of touch. Nat Rev Psychol 2023, 2: 459–471.Article  ...
Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms
Sleep Disorders in Neurodegenerative Diseases: Pathological Correlations and Underlying Mechanisms
Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple syst...
Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice
Neuronal and Glial YAP/TAZ in the Spinal Cord Contribute to the Development of Bone Cancer Pain in Mice
The treatment of bone cancer pain (BCP) remains a major clinical challenge, and the mechanisms underlying BCP remain poorl...
Elevation of HS Underlies Social Deficits in Environmental Factor Double-Hit Autism Model
Elevation of HS Underlies Social Deficits in Environmental Factor Double-Hit Autism Model
The underlying mechanism for the environmental factor-induced autism spectrum disorder (ASD) remains largely unclear. Cons...
Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse
Parvalbumin and Somatostatin Neurons in the Thalamic Reticular Nucleus Modulate Visual Information Processing in V1 of Mouse
The thalamic reticular nucleus (TRN) plays a crucial role in regulating sensory encoding, even at the earliest stages of v...
Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components
Dissecting Social Working Memory: Neural and Behavioral Evidence for Externally and Internally Oriented Components
Social working memory (SWM)—the ability to maintain and manipulate social information in the brain—plays a cru...
Electrophysiological Signatures of Visual Sensations Elicited by Direct Electrical Stimulation
Electrophysiological Signatures of Visual Sensations Elicited by Direct Electrical Stimulation
Direct electrical stimulation of the human cortex can produce subjective visual sensations, yet these sensations are unsta...
Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model
Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model
Uncovering the underlying process of epileptogenesis is crucial for developing effective treatment strategies for epilepsy...
Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia
Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia
Cerebral ischemia restricts cerebral blood flow (CBF), leading to unstable hemodynamics. Past studies of ischemia mainly f...
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation
USP47 Regulates Excitatory Synaptic Plasticity and Modulates Seizures in Murine Models by Blocking Ubiquitinated AMPAR Degradation
Epilepsy is a chronic neurological disorder affecting ~65 million individuals worldwide. Abnormal synaptic plasticity is o...
Pre-action Neuronal Encoding of Task Situation Uncertainty in the Medial Prefrontal Cortex of Rats
Pre-action Neuronal Encoding of Task Situation Uncertainty in the Medial Prefrontal Cortex of Rats
Humans and animals have a fundamental ability to use experiences and environmental information to organize behavior. It of...
Differential Resting-State Brain Activity Following Early- and Late-Night Sleep Loss
Differential Resting-State Brain Activity Following Early- and Late-Night Sleep Loss
Hafner M, Stepanek M, Taylor J, Troxel WM, van Stolk C. Why sleep matters-the economic costs of insufficient sleep: A cros...
Comparative Analysis of Histological Tools for Myelin
Comparative Analysis of Histological Tools for Myelin
Myelin is an essential structure that facilitates rapid saltatory conduction in the nervous system. Discrepancies in myeli...
Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD
Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD
Magnetic stimulation has made significant strides in the treatment of psychiatric disorders. Nonetheless, current magnetic...
Modulation of Ryanodine Receptors on Microglial Ramification, Migration, and Phagocytosis in an Alzheimer’s Disease Mouse Model
Modulation of Ryanodine Receptors on Microglial Ramification, Migration, and Phagocytosis in an Alzheimer’s Disease Mouse Model
Microglial functions are linked to Ca2+ signaling, with endoplasmic reticulum (ER) calcium stores playing a crucial role. ...
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