Egebjerg J, Bettler B, Hermans-Borgmeyer I, Heinemann S. Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA. Nature 1991, 351: 745–748.

Article  PubMed  CAS  Google Scholar 

Lerma J, Paternain AV, Rodríguez-Moreno A, López-García JC. Molecular physiology of kainate receptors. Physiol Rev 2001, 81: 971–998.

Article  PubMed  CAS  Google Scholar 

Palacios-Filardo J, Aller MI, Lerma J. Synaptic targeting of kainate receptors. Cereb Cortex 2016, 26: 1464–1472.

Article  PubMed  Google Scholar 

Huettner JE. Kainate receptors and synaptic transmission. Prog Neurobiol 2003, 70: 387–407.

Article  PubMed  CAS  Google Scholar 

Lerma J. Roles and rules of kainate receptors in synaptic transmission. Nat Rev Neurosci 2003, 4: 481–495.

Article  PubMed  CAS  Google Scholar 

Park Y, Jo J, Isaac JTR, Cho K. Long-term depression of kainate receptor-mediated synaptic transmission. Neuron 2006, 49: 95–106.

Article  PubMed  CAS  Google Scholar 

Schmitz D, Mellor J, Breustedt J, Nicoll RA. Presynaptic kainate receptors impart an associative property to hippocampal mossy fiber long-term potentiation. Nat Neurosci 2003, 6: 1058–1063.

Article  PubMed  CAS  Google Scholar 

Bortolotto ZA, Clarke VR, Delany CM, Parry MC, Smolders I, Vignes M. Kainate receptors are involved in synaptic plasticity. Nature 1999, 402: 297–301.

Article  PubMed  CAS  Google Scholar 

Madden DR. The structure and function of glutamate receptor ion channels. Nat Rev Neurosci 2002, 3: 91–101.

Article  PubMed  CAS  Google Scholar 

Contractor A, Swanson GT. Kainate receptors. In: The glutamate receptors. The Receptors. Totowa: Humana Press, 2008: 99–158.

Robert A, Armstrong N, Gouaux JE, Howe JR. AMPA receptor binding cleft mutations that alter affinity, efficacy, and recovery from desensitization. J Neurosci 2005, 25: 3752–3762.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sanders JM, Pentikäinen OT, Settimo L, Pentikäinen U, Shoji M, Sasaki M, et al. Determination of binding site residues responsible for the subunit selectivity of novel marine-derived compounds on kainate receptors. Mol Pharmacol 2006, 69: 1849–1860.

Article  PubMed  CAS  Google Scholar 

Burnashev N, Villarroel A, Sakmann B. Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues. J Physiol 1996, 496(Pt 1): 165–173.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Paternain AV, Cohen A, Stern-Bach Y, Lerma J. A role for extracellular Na+ in the channel gating of native and recombinant kainate receptors. J Neurosci 2003, 23: 8641–8648.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Plested AJR, Vijayan R, Biggin PC, Mayer ML. Molecular basis of kainate receptor modulation by sodium. Neuron 2008, 58: 720–735.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Plested AJR, Mayer ML. Structure and mechanism of kainate receptor modulation by anions. Neuron 2007, 53: 829–841.

Article  PubMed  CAS  Google Scholar 

Agrawal SG, Evans RH. The primary afferent depolarizing action of kainate in the rat. Br J Pharmacol 1986, 87: 345–355.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huettner JE. Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate and blockade of desensitization by Con A. Neuron 1990, 5: 255–266.

Article  PubMed  CAS  Google Scholar 

Handler A, Ginty DD. The mechanosensory neurons of touch and their mechanisms of activation. Nat Rev Neurosci 2021, 22: 521–537.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Qi L, Iskols M, Shi D, Reddy P, Walker C, Lezgiyeva K, et al. A mouse DRG genetic toolkit reveals morphological and physiological diversity of somatosensory neuron subtypes. Cell 2024, 187: 1508-1526.e16.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Smith ESJ, Lewin GR. Nociceptors: A phylogenetic view. J Comp Physiol A 2009, 195: 1089–1106.

Article  CAS  Google Scholar 

Dubin AE, Patapoutian A. Nociceptors: The sensors of the pain pathway. J Clin Invest 2010, 120: 3760–3772.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li CL, Li KC, Wu D, Chen Y, Luo H, Zhao JR, et al. Somatosensory neuron types identified by high-coverage single-cell RNA-sequencing and functional heterogeneity. Cell Res 2016, 26: 83–102.

Article  PubMed  CAS  Google Scholar 

Bautista M, Katselis GS, Chowdhury B, Chumala P, Mahendra R, Desai P, et al. Comparative proteomics analysis of growth-primed adult dorsal root ganglia reveals key molecular mediators for peripheral nerve regeneration. eNeuro 2023, 10: ENEURO.0168–ENEURO.0122.2022.

Bhuiyan SA, Xu M, Yang L, Semizoglou E, Bhatia P, Pantaleo KI, et al. Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia. Sci Adv 2024, 10: eadj9173.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hu G, Huang K, Hu Y, Du G, Xue Z, Zhu X, et al. Single-cell RNA-seq reveals distinct injury responses in different types of DRG sensory neurons. Sci Rep 2016, 6: 31851.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jung M, Dourado M, Maksymetz J, Jacobson A, Laufer BI, Baca M, et al. Cross-species transcriptomic atlas of dorsal root ganglia reveals species-specific programs for sensory function. Nat Commun 2023, 14: 366.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kupari J, Usoskin D, Parisien M, Lou D, Hu Y, Fatt M, et al. Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain. Nat Commun 2021, 12: 1510.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kupari J, Ernfors P. Molecular taxonomy of nociceptors and pruriceptors. Pain 2023, 164: 1245–1257.

Article  PubMed  PubMed Central  Google Scholar 

Nguyen MQ, von Buchholtz LJ, Reker AN, Ryba NJ, Davidson S. Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons. Elife 2021, 10: e71752.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Renthal W, Tochitsky I, Yang L, Cheng YC, Li E, Kawaguchi R, et al. Transcriptional reprogramming of distinct peripheral sensory neuron subtypes after axonal injury. Neuron 2020, 108: 128-144.e9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sharma N, Flaherty K, Lezgiyeva K, Wagner DE, Klein AM, Ginty DD. The emergence of transcriptional identity in somatosensory neurons. Nature 2020, 577: 392–398.

Article