The SWI/SNF chromatin remodeling complex subunit BAF53B as an immunohistochemical marker for neuroendocrine neoplasms

Oronsky B, Ma PC, Morgensztern D, Carter CA. Nothing but NET: a review of neuroendocrine tumors and carcinomas. Neoplasia. 2017;19:991–1002.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Diwakarla S, Fothergill LJ, Fakhry J, Callaghan B, Furness JB. Heterogeneity of enterochromaffin cells within the gastrointestinal tract. Neurogastroenterol Motil. 2017;29:1–5.

Article  Google Scholar 

Rezzani R, Franco C, Franceschetti L, Gianò M, Favero G. A focus on Enterochromaffin cells among the Enteroendocrine cells: localization, morphology, and role. Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23073758.

Article  PubMed  PubMed Central  Google Scholar 

Gheorghișan-Gălățeanu AA, Ilieșiu A, Lambrescu IM, Țăpoi DA. The Complex Histopathological and Immunohistochemical Spectrum of Neuroendocrine Tumors—An Overview of the Latest Classifications. Int J Mol Sci. 2023;24:1418.

Article  PubMed  PubMed Central  Google Scholar 

Wang Z, Liu C, Zheng S, Yao Y, Wang S, Wang X, et al. Molecular subtypes of neuroendocrine carcinomas: a cross-tissue classification framework based on five transcriptional regulators. Cancer Cell. 2024;42:1106-1125.e8.

Article  PubMed  CAS  Google Scholar 

Juhlin CC. Second-generation neuroendocrine immunohistochemical markers: reflections from clinical implementation. Biology (Basel). 2021;10:1–9.

Google Scholar 

Pozo K, Kollipara RK, Kelenis DP, Rodarte KE, Ullrich MS, Zhang X, et al. ASCL1, NKX2–1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer. iScience. 2021;24:1–23.

Article  Google Scholar 

Sakurai K, Ando T, Sakai Y, Mori Y, Nakamura S, Kato T, et al. PROX1 is a regulator of neuroendocrine-related gene expression in lung carcinoid. Hum Cell. 2024;37:1559–66.

Article  PubMed  CAS  Google Scholar 

Rindi G, Klimstra DS, Abedi-Ardekani B, Asa SL, Bosman FT, Brambilla E, et al. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol. 2018;31:1770–86.

Article  PubMed  PubMed Central  Google Scholar 

Gourisankar S, Krokhotin A, Wenderski W, Crabtree GR. Context-specific functions of chromatin remodellers in development and disease. Nat Rev Genet. 2024;25:340–61.

Article  PubMed  CAS  Google Scholar 

Kadoch C, Crabtree GR. Mammalian SWI/SNF chromatin remodeling complexes and cancer: mechanistic insights gained from human genomics. Sci Adv. 2015;1:1–17.

Article  Google Scholar 

Jones CA, Tansey WP, Weissmiller AM. Emerging themes in mechanisms of tumorigenesis by SWI/SNF subunit mutation. Epigenet Insight. 2022;15:25168657221115656.

Article  Google Scholar 

Euskirchen G, Auerbach RK, Snyder M. SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions. J Biol Chem. 2012;287:30897–905.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Păun O, Tan YX, Patel H, Strohbuecker S, Ghanate A, Cobolli-Gigli C, et al. Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation. Genes Dev. 2023;37:218–42.

Article  PubMed  PubMed Central  Google Scholar 

Sakurai K, Furukawa C, Haraguchi T, Inada KI, Shiogama K, Tagawa T, et al. Micrornas miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers. Cancer Res. 2011;71:1680–9.

Article  PubMed  CAS  Google Scholar 

Kobayashi K, Sakurai K, Hiramatsu H, Inada KI, Shiogama K, Nakamura S, et al. The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines. Sci Rep. 2015;5:8428.

Article  PubMed  PubMed Central  CAS  Google Scholar 

He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu XS, et al. Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies. Cancer Cell. 2024;42:1336-1351.e9.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Romero OA, Torres-Diz M, Pros E, Savola S, Gomez A, Moran S, et al. MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1. Cancer Discov. 2014;4:293–303.

Article  Google Scholar 

Han X, Chen W, Chen P, Zhou W, Rong Y, Lv Y, et al. Aberration of ARID1A is associated with the tumorigenesis and prognosis of sporadic nonfunctional pancreatic neuroendocrine tumors. Pancreas. 2020;49:514–23.

Article  PubMed  CAS  Google Scholar 

Redin E, Sridhar H, Zhan YA, Pereira Mello B, Zhong H, Durani V, et al. SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. J Hematol Oncol. 2024;17:1–19.

Google Scholar 

Vogel-Ciernia A, Wood MA. Neuron-specific chromatin remodeling: a missing link in epigenetic mechanisms underlying synaptic plasticity, memory, and intellectual disability disorders. Neuropharmacology. 2014;80:18–27.

Article  PubMed  CAS  Google Scholar 

Alfert A, Moreno N, Kerl K. The BAF complex in development and disease. Epigenetics Chromatin. 2019;12:1–15.

Article  Google Scholar 

Olave I, Wang W, Xue Y, Kuo A, Crabtree GR. Identification of a polymorphic, neuron-specific chromatin remodeling complex. Genes Dev. 2002;16:2509–17.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, et al. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron. 2007;56:94–108.

Article  PubMed  CAS  Google Scholar 

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483:603–7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sakurai K, Nagai A, Ando T, Sakai Y, Ideta Y, Hayashi Y, et al. Cytomorphology and gene expression signatures of anchorage-independent aggregations of oral cancer cells. Cancer Genomics. 2023;20:64–74.

Article  CAS  Google Scholar 

Cai L, De Berardinis RJ, Xie Y, Minna JD, Xiao G. A comparative study of neuroendocrine heterogeneity in small cell lung cancer and neuroblastoma. Mol Cancer Res. 2023;21:795–807.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Polley E, Kunkel M, Evans D, Silvers T, Delosh R, Laudeman J, et al. Small cell lung cancer screen of oncology drugs, investigational agents, and gene and microRNA expression. J Natl Cancer Inst. 2016;108:1–11.

Article  Google Scholar 

Cejas P, Xie Y, Font-Tello A, Lim K, Syamala S, Qiu X, et al. Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer. Nat Commun. 2021. https://doi.org/10.1038/s41467-021-26042-z.

Article  PubMed  PubMed Central  Google Scholar 

Augustyn A, Borromeo M, Wang T, Fujimoto J, Shao C, Dospoy PD, et al. ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers. Proc Natl Acad Sci U S A. 2014;111:14788–93.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Xie J, Chen P, Xie H, Sun Y, Huang Z, Wei R, et al. Exploration of gastric neuroendocrine carcinoma (GNEC) specific signaling pathways involved in chemoresistance via transcriptome and in vitro analysis. Comput Struct Biotechnol J. 2020;18:2610–20.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ishii J, Yazawa T, Chiba T, Shishido-Hara Y, Arimasu Y, Sato H, et al. PROX1 promotes secretory granule formation in medullary thyroid cancer cells. Endocrinology. 2016;157:1289–98.

Article  PubMed  CAS 

Comments (0)

No login
gif