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Robo4 inhibits neovascularization in oxygen-induced retinopathy by regulating ARF6 and VEGF
Robo4 inhibits neovascularization in oxygen-induced retinopathy by regulating ARF6 and VEGF
Retinopathy of prematurity (ROP) is an abnormal proliferative disease of retinal blood vessels. This study investigates th...
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone fracture healing is a complex physiologic process that aims at restoring the damaged bone to its pre-injury state and...
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
Knee osteoarthritis (KOA) is a degenerative joint disorder characterized by articular cartilage degeneration and synovial ...
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision re...
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Lung adenocarcinoma (LUAD) continues to be a major contributor to cancer-related deaths due to its aggressive nature and r...
The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis
The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis
The glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin has been reported to have increased expression w...
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening
Most drug discovery studies use 2D cell cultures and animal models for screening new chemical entities (NCEs), which often...
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme, and a growing body...
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling
Intestinal failure-associated liver disease (IFALD) is a life-threatening complication of short bowel syndrome (SBS), char...
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells
miR-487a-3p shows the potential of modulating adipose-derived stem cells (ADSCs) differentiation. This study aimed to inve...
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies
Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the...
The SWI/SNF chromatin remodeling complex subunit BAF53B as an immunohistochemical marker for neuroendocrine neoplasms
The SWI/SNF chromatin remodeling complex subunit BAF53B as an immunohistochemical marker for neuroendocrine neoplasms
The Switch/Sucrose Nonfermentable (SWI/SNF) complexes are chromatin remodeling factors that consist of multiple protein su...
MiR-34a regulates renal circadian rhythms during cisplatin-induced nephrotoxicity
MiR-34a regulates renal circadian rhythms during cisplatin-induced nephrotoxicity
El-Arabey AA. Dihydrotestosterone as mediator for cisplatin induced nephrotoxicity: New insight down the road. Toxicology....
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
β-Asarone regulates microglia polarization to alleviate TBI-induced nerve damage via Fas/FasL signaling axis
Acute injury and secondary injury caused by traumatic brain injury (TBI) seriously threaten the health of patients. The pu...
Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B
Curzerenone inactivates the nuclear factor-kappa B signaling to suppress malignancy and immune evasion in cervical cancer by targeting CSNK2B
Curzerenone is a major component of the traditional herbal medicine Curcumae Rhizoma with potential cancer-suppressing eff...
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers
Human pluripotent stem cells (hPSCs) have at least three distinct states: naïve pluripotency that represents the cell...
Loss of hepatocyte growth factor activator inhibitor type 1 (HAI-1) upregulates MMP-9 expression and induces degradation of the epidermal basement membrane
Loss of hepatocyte growth factor activator inhibitor type 1 (HAI-1) upregulates MMP-9 expression and induces degradation of the epidermal basement membrane
Hepatocyte growth factor activator inhibitor type 1 (HAI-1), which is encoded by the SPINT1 gene, is a membrane-associated...
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
Human amniotic epithelial stem cells, a potential therapeutic approach for diabetes and its related complications
The escalating diabetes prevalence has heightened interest in innovative therapeutic strategies for this disease and its c...
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Long non-coding RNA MSC-AS1 confers imatinib resistance of gastrointestinal stromal tumor cells by activating FNDC1 and ANLN-mediated PI3K/AKT pathway
Imatinib resistance is a major obstacle to the successful treatment of gastrointestinal stromal tumors (GIST). Long non-co...
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Taxifolin regulates SLC31A1-mediated cuproptosis and tumor progression in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary malignant neoplasm exhibiting a high mortality rate. Taxifolin is a naturally ...
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
Modeling the lymph node stromal cells in oral squamous cell carcinoma: insights into the stromal cues in nodal metastasis
The study explores the development and characterization of lymph node stromal cell cultures (LNSCs) from patients with ora...
Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
Identification of a novel GRHPR mutation in primary hyperoxaluria type 2 and establishment of patient-derived iPSC line
This research delves into Primary Hyperoxaluria Type 2 (PH2), an autosomal recessive disorder precipitated by a unique cas...
The dual role of PTPN22 in immune modulation and transplantation tolerance
The dual role of PTPN22 in immune modulation and transplantation tolerance
Wu J, Katrekar A, Honigberg LA, Smith AM, Conn MT, Tang J, et al. Identification of substrates of human protein-tyrosine p...
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
High glucose induces renal tubular epithelial cell senescence by inhibiting autophagic flux
Autophagy, a cellular degradation process involving the formation and clearance of autophagosomes, is mediated by autophag...
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
Inhibitory effects of the combination of rapamycin with gemcitabine plus paclitaxel on the growth of pancreatic cancer tumors
We previously examined the antitumor effects of short interfering RNA nanoparticles targeting mammalian target of rapamyci...
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
The multifaceted roles of aldolase A in cancer: glycolysis, cytoskeleton, translation and beyond
Cancer, a complicated disease characterized by aberrant cellular metabolism, has emerged as a formidable global health cha...
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy
Nimodipine ameliorates subarachnoid hemorrhage-induced neuroinflammation and injury by protecting mitochondrial function and regulating autophagy
Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke, and the neuroprotective effects of nimodipine following SAH...
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase
Establishment of a human ovarian endometrioid carcinoma cell line by constitutive expression of cyclin-dependent kinase 4, cyclin D1 and telomerase reverse transcriptase
Only a few human ovarian endometrioid carcinoma cell lines are currently available, partly due to the difficulty of establ...
The role of RhoA-ROCK signaling in benign prostatic hyperplasia: a review
The role of RhoA-ROCK signaling in benign prostatic hyperplasia: a review
Benign prostatic hyperplasia (BPH) is a common urological disease in middle-aged and elderly men. The main pathological me...
Establishment and characterization of NCC-SFT1-C1: a novel patient-derived cell line of solitary fibrous tumor
Establishment and characterization of NCC-SFT1-C1: a novel patient-derived cell line of solitary fibrous tumor
Solitary fibrous tumors (SFTs) are rare mesenchymal tumors characterized by recurrent NAB2::STAT6 gene fusion, which are a...
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