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DKK1 exacerbates dental pulp inflammation: insights from RNA-sequencing analysis
DKK1 exacerbates dental pulp inflammation: insights from RNA-sequencing analysis
Dickkopf-related protein 1 (DKK1) has been implicated in several inflammatory diseases; however, its role in pulpitis rema...
The sialyltransferase ST3GAL1 mediates MUCL1 sialylation to exacerbate breast cancer progression
The sialyltransferase ST3GAL1 mediates MUCL1 sialylation to exacerbate breast cancer progression
Breast cancer is highly heterogeneous and involves complex molecular mechanisms, posing significant therapeutic challenges...
Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway
Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway
Doxorubicin (DOX) is a commonly prescribed chemotherapeutic regimen, but its practice is challenged by cardiotoxicity risk...
Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone
Establishment and characterization of NCC-GCTB16-C1: novel patient-derived cell line of giant cell tumor of bone
Giant cell tumor of bone (GCTB) is a locally aggressive osteolytic bone tumor characterized by recurrent mutation in the H...
Femtosecond label-free imaging evaluates the metabolism of mesenchymal stromal cells
Femtosecond label-free imaging evaluates the metabolism of mesenchymal stromal cells
Mesenchymal stromal cells (MSCs) hold significant promise in regenerative medicine, yet their clinical application is hind...
Unveiling TNFRSF19: a novel tumor suppressor targeting endoplasmic reticulum stress and LGR5/Wnt/β-catenin in cervical cancer
Unveiling TNFRSF19: a novel tumor suppressor targeting endoplasmic reticulum stress and LGR5/Wnt/β-catenin in cervical cancer
TNF Receptor Superfamily Member 19 (TNFRSF19) has been implicated in the advancement of several types of cancer. However, ...
Rolled amniotic membrane for practical vascular graft development: a scoping review
Rolled amniotic membrane for practical vascular graft development: a scoping review
Small-diameter vascular grafts remain a clinical challenge due to thrombosis, stenosis, and poor long-term patency of synt...
Arginine deprivation induces ROS dependent autophagic cell death in human acute myeloid leukemia cells
Arginine deprivation induces ROS dependent autophagic cell death in human acute myeloid leukemia cells
In this study, we assess the activation of autophagy and its impact on cytotoxicity following [HuArgI (Co)-PEG5000]-induce...
CBC3T-3: a novel patient-derived cisplatin-resistant distal cholangiocarcinoma cell line harboring multiple missense mutations
CBC3T-3: a novel patient-derived cisplatin-resistant distal cholangiocarcinoma cell line harboring multiple missense mutations
Distal cholangiocarcinoma (dCCA) is a malignant tumor characterized by a challenging diagnosis, high invasiveness, and ext...
Advancing diagnostic biomarkers in Alzheimer’s disease: interdisciplinary innovations and technological frontiers
Advancing diagnostic biomarkers in Alzheimer’s disease: interdisciplinary innovations and technological frontiers
Developing diagnostic biomarkers for Alzheimer’s disease (AD) is at the cutting edge of interdisciplinary research a...
Ubiquitously expressed prefoldin-like chaperone (UXT) regulates putrescine metabolism and promotes colorectal cancer progression
Ubiquitously expressed prefoldin-like chaperone (UXT) regulates putrescine metabolism and promotes colorectal cancer progression
Colorectal cancer (CRC) is a prevalent and increasingly common malignancy that poses significant threats to patient surviv...
An overview of the developments in 3D cancer cell models, assay techniques, and imaging modalities
An overview of the developments in 3D cancer cell models, assay techniques, and imaging modalities
Cancer biology is a constantly evolving field of study due to the dynamic and complex nature of biological systems. The un...
Induction of activating transcription factor 3 (ATF3) in the cerebral cortex of a mouse model of blast-induced traumatic brain injury
Induction of activating transcription factor 3 (ATF3) in the cerebral cortex of a mouse model of blast-induced traumatic brain injury
Traumatic brain injury (TBI) is a leading cause of long-term disabilities and mortality worldwide. Blast-induced TBI (bTBI...
AKR1B10 drives hepatic steatosis and inflammation in metabolic dysfunction-associated steatotic liver disease via PI3K/AKT-mediated autophagy suppression
AKR1B10 drives hepatic steatosis and inflammation in metabolic dysfunction-associated steatotic liver disease via PI3K/AKT-mediated autophagy suppression
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder marked by excessive hep...
Pathological and therapeutic implications of Notch overexpression in claudin-low breast cancers
Pathological and therapeutic implications of Notch overexpression in claudin-low breast cancers
Claudin-low breast cancers (BCs), representing approximately 1.5–14% of all BCs, are characterized by high aggressiv...
Exploring the role of protein homeostasis regulation in glycolysis in head and neck tumors
Exploring the role of protein homeostasis regulation in glycolysis in head and neck tumors
Metabolic reprogramming is a hallmark of cancer. Tumor cells adapt to their environment by modulating glucose, lipid, and ...
Extracellular vesicle-derived CDCP1 promotes chemoresistance and macrophage polarization in breast cancer
Extracellular vesicle-derived CDCP1 promotes chemoresistance and macrophage polarization in breast cancer
Breast cancer derived extracellular vesicles (EVs) mediate tumor progression through surface protein-dependent intercellul...
Pathogenesis and therapeutic strategies for neuropsychiatric lupus centered on innate immune activation
Pathogenesis and therapeutic strategies for neuropsychiatric lupus centered on innate immune activation
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a serious central nervous system complication of systemic lupus e...
Human peritoneal CCR2CRIg macrophage subset exhibits embryonic origin-like phenotypes
Human peritoneal CCR2CRIg macrophage subset exhibits embryonic origin-like phenotypes
Recent studies in mouse models have demonstrated that macrophages in adult tissues are maintained not only by the differen...
Robo4 inhibits neovascularization in oxygen-induced retinopathy by regulating ARF6 and VEGF
Robo4 inhibits neovascularization in oxygen-induced retinopathy by regulating ARF6 and VEGF
Retinopathy of prematurity (ROP) is an abnormal proliferative disease of retinal blood vessels. This study investigates th...
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone marrow mesenchymal stem cell-derived exosomal METTL14 promotes the osteogenic differentiation of MC3T3-E1 cells by regulating BMP2 in bone fracture recovery
Bone fracture healing is a complex physiologic process that aims at restoring the damaged bone to its pre-injury state and...
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
ATG5-mediated cGAS-STING-NLRP3 axis alleviates symptoms of knee osteoarthritis
Knee osteoarthritis (KOA) is a degenerative joint disorder characterized by articular cartilage degeneration and synovial ...
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
Unveiling the vital role of OGG1 in inflammation, vascular endothelial damage, and cell death in obstetric and gynecological diseases
The DNA repair enzyme 8-oxoguanine DNA glycosylase-1 (OGG1) plays a crucial role in the initiation of DNA base excision re...
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Exosomal FGD5-AS1 promotes proliferation of lung cancer cells under hypoxia by inhibiting miR-1179 and activating P-cadherin
Lung adenocarcinoma (LUAD) continues to be a major contributor to cancer-related deaths due to its aggressive nature and r...
The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis
The cell-surface serine protease prostasin is lost during cervical squamous cell carcinogenesis
The glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin has been reported to have increased expression w...
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening
Simulating tumor complexity: 3D pancreatic tumor spheroid model for improved drug screening
Most drug discovery studies use 2D cell cultures and animal models for screening new chemical entities (NCEs), which often...
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Nicotinamide N-methyltransferase enhances paclitaxel resistance in ovarian clear cell carcinoma
Nicotinamide N-methyltransferase (NNMT) is an S-adenosyl-l-methionine (SAM)-dependent cytosolic enzyme, and a growing body...
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling
100% Fish oil-based lipid emulsion inhibits hepatic stellate cell activation via suppression of the TGF-β1 autocrine signaling
Intestinal failure-associated liver disease (IFALD) is a life-threatening complication of short bowel syndrome (SBS), char...
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells
FTO inhibited miR-487a-3p biosynthesis via N6-methyladenosine-dependent pathway to promote WNT5A-mediated osteogenic differentiation of adipose-derived stem cells
miR-487a-3p shows the potential of modulating adipose-derived stem cells (ADSCs) differentiation. This study aimed to inve...
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies
SIRT1 as a potential target for age-related eye diseases: mechanisms and therapeutic strategies
Age-related eye diseases (AREDs) are the leading cause of visual impairment in the elderly, affecting the structure of the...
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