Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73:17–48. https://doi.org/10.3322/caac.21763.

Article  PubMed  Google Scholar 

Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK. Non-small-cell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer. 2014;14:535–46. https://doi.org/10.1038/nrc3775.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herbst RS, Morgensztern D, Boshoff C. The biology and management of non-small cell lung cancer. Nature. 2018;553:446–54. https://doi.org/10.1038/nature25183.

Article  CAS  PubMed  Google Scholar 

Jonna S, Subramaniam DS. Molecular diagnostics and targeted therapies in non-small cell lung cancer (NSCLC): an update. Discov Med. 2019;27:167–70.

PubMed  Google Scholar 

Nemeth K, Bayraktar R, Ferracin M, Calin GA. Non-coding RNAs in disease: from mechanisms to therapeutics. Nat Rev Genet. 2024;25:211–32. https://doi.org/10.1038/s41576-023-00662-1.

Article  CAS  PubMed  Google Scholar 

Huarte M. The emerging role of lncRNAs in cancer. Nat Med. 2015;21:1253–61. https://doi.org/10.1038/nm.3981.

Article  CAS  PubMed  Google Scholar 

Kopp F, Mendell JT. Functional classification and experimental dissection of long noncoding RNAs. Cell. 2018;172:393–407. https://doi.org/10.1016/j.cell.2018.01.011.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang B, Kuai F, Chen Z, Fu D, Liu J, Wu Y, Zhong J. miR-634 decreases the radioresistance of human breast cancer cells by targeting STAT3. Cancer Biother Radiopharm. 2020;35:241–8. https://doi.org/10.1089/cbr.2019.3220.

Article  CAS  PubMed  Google Scholar 

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? Cell. 2011;146:353–8. https://doi.org/10.1016/j.cell.2011.07.014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amicone L, Marchetti A, Cicchini C. The lncRNA HOTAIR: a pleiotropic regulator of epithelial cell plasticity. J Exp Clin Cancer Res. 2023;42:147. https://doi.org/10.1186/s13046-023-02725-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li D, et al. Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302e. In Vitro Cell Dev Biol Anim. 2019;55:577–85. https://doi.org/10.1007/s11626-019-00376-x.

Article  CAS  PubMed  Google Scholar 

Zhang N, et al. LncRNA FGD5-AS1 functions as an oncogene to upregulate GTPBP4 expression by sponging miR-873–5p in hepatocellular carcinoma. Eur J Histochem. 2021. https://doi.org/10.4081/ejh.2021.3300.

Article  PubMed  PubMed Central  Google Scholar 

Fang K, et al. lncRNA FGD5-AS1 promotes breast cancer progression by regulating the hsa-miR-195-5p/NUAK2 axis. Mol Med Rep. 2021. https://doi.org/10.3892/mmr.2021.12099.

Article  PubMed  PubMed Central  Google Scholar 

Cui F, Luo P, Bai Y, Meng J. Silencing of long non-coding RNA FGD5-AS1 inhibits the progression of non-small cell lung cancer by regulating the miR-493-5p/DDX5 axis. Technol Cancer Res Treat. 2021;20:1533033821990007. https://doi.org/10.1177/1533033821990007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han QF, et al. Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer. Mol Cancer. 2022;21:207. https://doi.org/10.1186/s12943-022-01671-0.

Article  PubMed  PubMed Central  Google Scholar 

Valadi H, et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654–9. https://doi.org/10.1038/ncb1596.

Article  CAS  PubMed  Google Scholar 

Hu Q, Ma H, Chen H, Zhang Z, Xue Q. LncRNA in tumorigenesis of non-small-cell lung cancer: From bench to bedside. Cell Death Discov. 2022;8:359. https://doi.org/10.1038/s41420-022-01157-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu J, et al. Hypoxic lung adenocarcinoma-derived exosomal miR-1290 induces M2 macrophage polarization by targeting SOCS3. Cancer Med. 2023;12:12639–52. https://doi.org/10.1002/cam4.5954.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen K, et al. Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression. Int J Biol Sci. 2022;18:1220–37. https://doi.org/10.7150/ijbs.67675.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen DD, et al. LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer. Mol Cancer. 2022;21:75. https://doi.org/10.1186/s12943-022-01557-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foggetti G, et al. Genetic determinants of EGFR-driven lung cancer growth and therapeutic response in vivo. Cancer Discov. 2021;11:1736–53. https://doi.org/10.1158/2159-8290.CD-20-1385.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu P, et al. Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA. Mol Cancer. 2020;19:22. https://doi.org/10.1186/s12943-020-1147-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan Y, et al. Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1. 2020. Biosci Rep. https://doi.org/10.1042/BSR20193309.

He CK, et al. LncRNA FGD5-AS1 enhances the proliferation and stemness of hepatocellular carcinoma cells through targeting miR-223 and regulating the expression of ECT2 and FAT1. Hepatol Res. 2022;52:614–29. https://doi.org/10.1111/hepr.13767.

Article  CAS  PubMed  Google Scholar 

He N, et al. The role of long non-coding RNA FGD5-AS1 in cancer. Bioengineered. 2022;13:11026–41. https://doi.org/10.1080/21655979.2022.2067292.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8:237–55. https://doi.org/10.7150/thno.21945.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu C, Wang X, Wang Y, Wang K. Functions and underlying mechanisms of lncRNA HOTAIR in cancer chemotherapy resistance. Cell Death Discov. 2022;8:383. https://doi.org/10.1038/s41420-022-01174-3.

Article  PubMed  PubMed Central  Google Scholar 

Lin C, et al. MicroRNA-1179 inhibits the proliferation, migration and invasion of human pancreatic cancer cells by targeting E2F5. Chem Biol Interact. 2018;291:65–71. https://doi.org/10.1016/j.cbi.2018.05.017.

Article  CAS  PubMed  Google Scholar 

Kaszak I, et al. Role of cadherins in cancer-a review. Int J Mol Sci. 2020. https://doi.org/10.3390/ijms21207624.