Phosphorylation as a regulatory mechanism of HP1 protein multifunctionality

Aagaard L (1999) Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3–9 encode centromere-associated proteins which complex with the heterochromatin component M31. EMBO J 18(7):1923–1938. https://doi.org/10.1093/emboj/18.7.1923

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abe Y et al (2016) HP1-assisted Aurora B kinase activity prevents chromosome segregation errors. Dev Cell 36(5):487–497. https://doi.org/10.1016/j.devcel.2016.02.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adams MD et al (2000) The Genome Sequence of Drosophila melanogaster, Science, 287(5461), pp. 2185–2195. Available at: https://doi.org/10.1126/science.287.5461.2185

Akhtar A, Gasser SM (2007) The nuclear envelope and transcriptional control. Nat Rev Genet 8(7):507–517. https://doi.org/10.1038/nrg2122

Article  CAS  PubMed  Google Scholar 

Allshire RC, Madhani HD (2018) Ten principles of heterochromatin formation and function. Nat Rev Mol Cell Biol 19(4):229–244. https://doi.org/10.1038/nrm.2017.119

Article  CAS  PubMed  Google Scholar 

Andrulis ED (1998) Perinuclear localization of chromatin facilitates transcriptional silencing. Nature 394(6693):592–595. https://doi.org/10.1038/29100

Article  CAS  PubMed  Google Scholar 

Assland R, Stewart F (1995) The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1. Nucleic Acids Res 23(16):3168–3173. https://doi.org/10.1093/nar/23.16.3168

Article  Google Scholar 

Azzaz AM et al (2014) Human heterochromatin protein 1α promotes nucleosome associations that drive chromatin condensation. J Biol Chem 289(10):6850–6861. https://doi.org/10.1074/jbc.M113.512137

Article  CAS  PubMed  PubMed Central  Google Scholar 

Badugu R (2005) Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution. Chromosoma 113(7):370–384. https://doi.org/10.1007/s00412-004-0324-2

Article  CAS  PubMed  Google Scholar 

Bannister AJ et al (2001) Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature 410(6824):120–124. https://doi.org/10.1038/35065138

Article  CAS  PubMed  Google Scholar 

Belotserkovskaya R et al (2003) Fact facilitates transcription-dependent nucleosome alteration. Science 301(5636):1090–1093. https://doi.org/10.1126/science.1085703

Article  CAS  PubMed  Google Scholar 

Bensaha S et al (2025) HP1 loses its chromatin clustering and phase separation function across evolution. Nat Commun 16(1):6375. https://doi.org/10.1038/s41467-025-61749-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Black DL (2003) Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 72:291–336. https://doi.org/10.1146/annurev.biochem.72.121801.161720

Article  CAS  PubMed  Google Scholar 

Bosch-Presegué L (2017) Mammalian HP1 isoforms have specific roles in heterochromatin structure and organization. Cell Rep 21(8):2048–2057. https://doi.org/10.1016/j.celrep.2017.10.092

Article  CAS  PubMed  Google Scholar 

Brennan L et al (2024) HP1a promotes chromatin liquidity and drives spontaneous heterochromatin compartmentalization. Available at: https://doi.org/10.1101/2024.10.18.618981

Canzio D et al (2011) Chromodomain-mediated oligomerization of HP1 suggests a nucleosome-bridging mechanism for heterochromatin assembly. Mol Cell 41(1):67–81. https://doi.org/10.1016/j.molcel.2010.12.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cartwright IL et al (1982) Chromatin Structure and Gene Activity: The Role of Nonhistone Chromosomal Protein, Critical Reviews in Biochemistry [Preprint]. Available at: https://doi.org/10.3109/10409238209108709

Chakraborty A, Prasanth SG (2014) Phosphorylation–dephosphorylation cycle of HP1α governs accurate mitotic progression. Cell Cycle 13(11):1663–1670. https://doi.org/10.4161/cc.29065

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chakraborty A, Prasanth KV, Prasanth SG (2014) Dynamic phosphorylation of HP1α regulates mitotic progression in human cells. Nat Commun 5(1):3445. https://doi.org/10.1038/ncomms4445

Article  CAS  PubMed  Google Scholar 

Chiolo I (2011) Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell 144(5):732–744. https://doi.org/10.1016/j.cell.2011.02.012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chow TT et al (2018) Local enrichment of HP1alpha at telomeres alters their structure and regulation of telomere protection. Nat Commun 9(1):3583. https://doi.org/10.1038/s41467-018-05840-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen P (2002) The origins of protein phosphorylation. Nat Cell Biol 4(5):E127–E130. https://doi.org/10.1038/ncb0502-e127

Article  CAS  PubMed  Google Scholar 

Copley KE, Shorter J (2023) Repetitive elements in aging and neurodegeneration. Trends Genet 39(5):381–400. https://doi.org/10.1016/j.tig.2023.02.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cowieson NP (2000) Dimerisation of a chromo shadow domain and distinctions from the chromodomain as revealed by structural analysis. Curr Biol 10(9):517–525. https://doi.org/10.1016/S0960-9822(00)00467-X

Article  CAS  PubMed  Google Scholar 

Cramer P (2019) Organization and regulation of gene transcription. Nature 573(7772):45–54. https://doi.org/10.1038/s41586-019-1517-4

Article  CAS  PubMed  Google Scholar 

Cryderman DE et al (1998) Characterization of sequences associated with position-effect variegation at pericentric sites in Drosophila heterochromatin. Chromosoma 107(5):277–285. https://doi.org/10.1007/s004120050309

Article  CAS  PubMed  Google Scholar 

Cryderman DE (2005) Role of Drosophila HP1 in euchromatic gene expression. Dev Dyn 232(3):767–774. https://doi.org/10.1002/dvdy.20310

Article  CAS  PubMed  Google Scholar 

Dawson MA et al (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin. Nature 461(7265):819–822. https://doi.org/10.1038/nature08448

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Koning L (2009) Heterochromatin protein 1α: a hallmark of cell proliferation relevant to clinical oncology. EMBO Mol Med 1(3):178–191. https://doi.org/10.1002/emmm.200900022

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Lucia F (2005) HP1 modulates the transcription of cell-cycle regulators in drosophila melanogaster. Nucleic Acids Res 33(9):2852–2858. https://doi.org/10.1093/nar/gki584

Article  CAS  PubMed  PubMed Central  Google Scholar 

Desiere F (2006) The peptideatlas project. Nucleic Acids Res 34(90001):D655–D658.

Comments (0)

No login
gif