His lab pioneered the single cell sequencing field and has systematically developed a serial of single cell functional genomic sequencing technologies (the first single-cell DNA methylome sequencing technology (scRRBS, 2013), the first single-cell multi-omics sequencing technology (scTrio-seq, 2016), the first single-cell multi-epigenomics sequencing technology (scCOOL-seq, 2017), the first single molecule sequencing (SMS) platform-based high-precision single-cell RNA-seq technology (SCAN-seq, 2020), the first SMS platform-based single-cell genome sequencing technology (SMOOTH-seq, 2021), the first SMS platform-based single-cell ATAC-seq technology (scNanoATAC-seq, 2023), the first SMS platform-based single-cell Hi-C technology (scNanoHi-C, 2023), the first SMS platform-based single-cell DNA template strand sequencing (NanoStrand-seq, 2024), the first SMS platform-based single-cell CUT&Tag technology (scNanoSeq_CUT&Tag, 2024), and the first SMS platform-based single cell multi-omics sequencing technology (scNanoCOOL-seq, 2023)).