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PrePPI – Structure-based prediction of protein-protein interactomes and networks
Numerous databases of protein-protein interactions (PPIs) are available in the literature. Some, such as STRING [1], BioGR...
Rising Star: Single Cell Omics Technologies: When Whole Omics Analysis Meets Single Cell Resolution
His lab pioneered the single cell sequencing field and has systematically developed a serial of single cell functional gen...
Rising Stars: Adaptation to Environment: From Hormone Signaling to Gene Silencing
Plants are sessile organisms that rely on multilayered signaling networks to integrate internal hormonal cues with externa...
Deciphering Plant-Microbe Symbioses: A Molecular Blueprint for Precision Agriculture
Plants constantly interact with the microbes that surround them, engaging in a spectrum of relationships ranging from bene...
Rising Stars: In vivo Monitoring of Neurochemical Dynamics by Genetically Encoded Neuromodulator Sensors
The human brain consists of billions of neurons interconnected by chemical synapses, where communication is mediated by th...
Rising Star: Exploring Weak Biomolecular Interactions: My Steady and Evolving Journey
This manuscript reflects the early stages of my ongoing journey into weak biomolecular interactions, beginning with my stu...
Rising Stars: Molecular Mechanisms of Ligand Recognition and Functional Modulation of GPCRs
GPCRs constitute the largest family of membrane proteins in mammals, comprising over 800 members [1], [2]. These receptors...
Rising Star: G Protein-coupled Receptors (GPCRs) in Microenvironment Pharmacology and Sensory Perception Pharmacology
G protein–coupled receptors (GPCRs) constitute the largest and most versatile family of membrane proteins in eukaryotes, m...
Rising Star: Combining Bioinformatics and Experimental Biology to Decoding Non-coding RNAs and RNA Modifications
Xiu-Jie Wang studied biochemistry as a master student at Hong Kong University of Sciences and Technology, and obtained her...
Structural Basis for Non-classical WIN Peptides Recognition by WDR5
WDR5 is a highly conserved scaffolding protein and an essential core component of multiple chromatin-modifying complexes [...
The Anticancer Drug Mitoxantrone Triggers the Formation of Ribosome-enriched Stress Granules Independently of the Classical Translational Control Pathways
Mitoxantrone (MIT) is a chemotherapeutic drug widely used for its DNA intercalation and inhibition of topoisomerase. In th...
Crystal Structure of PH0140: Exogenous Amino Acids Induce Open Octameric Assembly Enables PromoterTTTT Binding for Transcription Regulation
Members of the Leucine-Responsive regulatory protein (Lrp)/Asparagine synthase C protein (AsnC) family are global or speci...
Oligomerization-Dependent Regulation of LrhA Controls Bacterial Flagellar Biosynthesis
Bacterial flagella are whip-like structures that drive motility, allowing bacteria to move toward favorable conditions or ...
CEP290 is Associated With Chromatin Accessibility of Hepatitis B virus cccDNA
Hepatitis B virus (HBV) infection remains a major global public health challenge. Recent estimates indicate that approxima...
Rising Star: Rewriting the Code of Life for the Future of Food
Journal of Molecular BiologyVolume 438, Issue 8, 15 April 2026, 169683Author links open overlay panelCaixia GaoShow moreHi...
Rising Stars: Molecular and Functional Diversity of the Sensory Nervous System
In the peripheral sensory nervous system, the NG and the DRG, as two major clusters of sensory neurons, exhibit significan...
Importance of Riboswitch-regulated Genes for Pseudomonas aeruginosa
Riboswitches offer a promising avenue as targets for the development of novel bacterial antibiotics. For this approach to ...
SFPQ Promotes Homologous Recombination via mRNA Stabilization of RAD51 and Its Paralogs
The ability of cells to preserve genome integrity is fundamental to cellular homeostasis. Failure to properly repair DNA d...
Lysosomal Degradation of ER Client Proteins by ER-phagy and Related Pathways
The endoplasmic reticulum (ER) is a major site of cellular protein synthesis. Degradation of overabundant, misfolded, aggr...
The Role of WIPI2, ATG16L1 and ATG12-ATG5 in Selective and Nonselective Autophagy
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169138Author links open overlay panel, , , Highlights...
Multifaceted Roles of the ATG8 Protein Family in Plant Autophagy: From Autophagosome Biogenesis to Cargo Recognition
In plant cells, autophagy is an essential quality control process by forming a double-membrane structure named the autopha...
ATG9 Not Just an Autophagy Related Protein
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169288Author links open overlay panel, Highlights•ATG...
Steroid Signaling in Autophagy
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169134Author links open overlay panel, Highlights•Ste...
The Life and Times of Brain Autophagic Vesicles
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169105Author links open overlay panel, , Highlights•N...
Mitophagy in Neurons: Mechanisms Regulating Mitochondrial Turnover and Neuronal Homeostasis
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169161Author links open overlay panel, Highlights•PIN...
Autophagy Dysfunction and Neurodegeneration: Where Does It Go Wrong?
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169219Author links open overlay panel, Highlights•Inc...
Rest, Repair, Repeat: The Complex Relationship of Autophagy and Sleep
Journal of Molecular BiologyVolume 437, Issue 18, 15 September 2025, 169227Author links open overlay panel, , , Highlights...
The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy
Mitophagy, the selective degradation of mitochondria, is essential for retinal ganglion cell (RGC) differentiation and ret...
DropFit: Determination of the Critical Concentration for Protein Liquid–Liquid Phase Separation
Journal of Molecular BiologyVolume 437, Issue 19, 1 October 2025, 169294Author links open overlay panel, , , Highlights•De...
CNPI: Rapid Analyses of Human Copy Number Data
Tools for genotyping copy number in whole-genome sequencing (WGS) data exist. Despite their availability, there are a limi...
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