Akita K, Isoda K, Shimada K, Daida H (2015) Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice. J Am Heart Assoc 4:e001469
Article PubMed PubMed Central Google Scholar
Albert-Weißenberger C, Várrallyay C, Raslan F, Kleinschnitz C, Sirén A-L (2012) An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice. Exp Transl Stroke Med 4:1–5
Article PubMed PubMed Central Google Scholar
Aldeeb RAE, Ibrahim SSA, Khalil IA, Ragab GM, El-Gazar AA, Taha AA et al (2024) Enhancing collagen based nanoemulgel for effective topical delivery of aceclofenac and citronellol oil: formulation, optimization, in-vitro evaluation, and in-vivo osteoarthritis study with a focus on HMGB-1/RAGE/NF-κB pathway, Klotho, and miR-499a. Drug Deliv Transl Res. https://doi.org/10.1007/s13346-024-01548-3
Article PubMed PubMed Central Google Scholar
Alsemeh AE, Abdullah DM (2022) Protective effect of alogliptin against cyclophosphamide-induced lung toxicity in rats: impact on PI3K/Akt/FoxO1 pathway and downstream inflammatory cascades. Cell Tissue Res 388:417–438
Article PubMed PubMed Central CAS Google Scholar
Arab HH, Khames A, Alsufyani SE, El-Sheikh AAK, Gad AM (2023) Targeting the endoplasmic reticulum stress-linked PERK/GRP78/CHOP pathway with magnesium sulfate attenuates chronic-restraint-stress-induced depression-like neuropathology in rats. Pharmaceuticals. https://doi.org/10.3390/ph16020300
Article PubMed PubMed Central Google Scholar
Arifin WN, Zahiruddin WM (2017) Sample size calculation in animal studies using resource equation approach. Malaysian J Med Sci MJMS 24:101
Bahlakeh G, Gorji A, Soltani H, Ghadiri T (2021) MicroRNA alterations in neuropathologic cognitive disorders with an emphasis on dementia: lessons from animal models. J Cell Physiol 236:806–823
Article PubMed CAS Google Scholar
Bancroft JD, Gamble M (2008) Theory and practice of histological techniques (Elsevier health sciences)
Bansal PK, Deshmukh R (2018) Animal models of neurological disorders. Principle and working procedure for animal models of neurological disorders
Banzhaf-Strathmann J, Benito E, May S, Arzberger T, Tahirovic S, Kretzschmar H et al (2014) Micro RNA ‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer’s disease. EMBO J 33:1667–1680
Article PubMed PubMed Central CAS Google Scholar
Benarroch EE (2015) CLINICAL IMPLICATIONS OF NEUROSCIENCE RESEARCH Section Editor Brain-derived neurotrophic factor Regulation, effects, and potential clinical relevance
Blanchard OL, Smoliga JM (2015) Translating dosages from animal models to human clinical trials—revisiting body surface area scaling. FASEB J 29:1629–1634
Article PubMed CAS Google Scholar
Botros SR, Matouk AI, Amin A, Heeba GH (2024) Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways. Front Pharmacol 15:1353029
Article PubMed PubMed Central CAS Google Scholar
Chen G, Fan Z, Wang X, Ma C, Bower KA, Shi X et al (2007) Brain-derived neurotrophic factor suppresses tunicamycin-induced upregulation of CHOP in neurons. J Neurosci Res 85:1674–1684
Article PubMed PubMed Central CAS Google Scholar
Chen Y, Sun Y, Chen L, Xu X, Zhang X, Wang B et al (2013) MiRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling. Mol Med Rep 7:1579–1584
Article PubMed CAS Google Scholar
Chen YF, Wei YY, Yang CC, Liu CJ, Yeh LY, Chou CH et al (2019) MiR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A. Redox Biol 22:101140
Article PubMed PubMed Central CAS Google Scholar
Cogswell J, Ward J, Taylor I, Waters M, Shi Y, Cannon B et al (2008) Identification of MiRNA changes in Alzheimer’s.pdf. J Alzheimer’s Dis 14:27–41
Costanza A, Weber K, Gandy S, Bouras C, Hof PR, Giannakopoulos P et al (2011) Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. Neuropathol Appl Neurobiol 37:570–584
Article PubMed PubMed Central CAS Google Scholar
Cui W, Leng B, Wang G (2019) Klotho protein inhibits H2O2-induced oxidative injury in endothelial cells via regulation of PI3K/AKT/Nrf2/HO-1 pathways. Can J Physiol Pharmacol 97:370–376
Article PubMed CAS Google Scholar
Dai L, Huang C, Chen L, Shan G, Li Z (2015) Altered expression of microRNAs in the response to ER stress. Sci Bull 60:202–209
Darsalia V, Ortsääter H, Olverling A, Darlööf E, Wolbert P, Nyströöm T et al (2013) The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: acomparison with glimepiride. Diabetes 62:1289–1296
Delic V, Beck KD, Pang KCH, Citron BA (2020) Biological links between traumatic brain injury and Parkinson’s disease. Acta Neuropathol Commun 8:1–16
Demediuk P, Saunders RD, Horrocks LA, Clendenon NR, Means ED, Anderson DK (1985) Changes in lipid metabolism in traumatized spinal cord. Prog. Brain Res 63:211–226
Dong Q, Teng S-W, Wang Y, Qin F, Li Y, Ai L-L et al (2019) Sitagliptin protects thecognition function of the Alzheimer’s disease mice through activating glucagon-like peptide-1and BDNF-TrkB signalings. Neurosci Lett 696:184–190
Duran-Aniotz C, Martínez G, Hetz C (2014) Memory loss in Alzheimer’s disease: are the alterations in the UPR network involved in the cognitive impairment? Front Aging Neurosci 6:10–12
Edwards S, Corrigan F, Collins L (2025) Lasting impact: exploring the brain mechanisms that link traumatic brain injury to Parkinson ’ s disease. Mol. Neurobiol
El-Gazar AA, Soubh AA, Mohamed EA, Awad AS, El-Abhar HS (2019) Morin post-treatment confers neuroprotection in a novel rat model of mild repetitive traumatic brain injury by targeting dementia markers, APOE, autophagy and Wnt/β-catenin signaling pathway. Brain Res 1717:104–116
Article PubMed CAS Google Scholar
El-Gazar AA, El-Emam SZ, M. El-Sayyad S, El-Mancy SS, Fayez SM, Sheta NM et al (2024a) Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: regulation of miR-155 and miR-146a/BDNF/ Klotho/Foxo3a cue. Int Immunopharmacol 134:112118
Article PubMed CAS Google Scholar
El-Gazar AA, Soubh AA, Abdallah DM, Ragab GM, El-Abhar HS (2024b) Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: unveiling the PPAR-γ/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats. Int Immunopharmacol 139:112774
Article PubMed CAS Google Scholar
El-Sahar AE, Shiha NA, Sayed N.S. El, Ahmed LA (2021) Alogliptin attenuates lipopolysaccharide-induced neuroinflammation in mice through modulation of TLR4/MYD88/NF-κB and miRNA-155/SOCS-1 signaling pathways. Int J Neuropsychopharmacol 24:158–169
Article PubMed CAS Google Scholar
El-Sayed SS, Ali SO, Ibrahim WW (2024) Potential neuroprotective and autophagy-enhancing effects of alogliptin on lithium/pilocarpine-induced seizures in rats: targeting the AMPK/SIRT1/Nrf2 axis. Life Sci 352:122917
Article PubMed CAS Google Scholar
Feng J, Zhang Z, Wallace MB, Stafford JA, Kaldor SW, Kassel DB et al (2008) Discovery of alogliptin: A potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV (Journal of Medicinal Chemistry (2007) 50, (2297–2300)). J. Med. Chem. 51: 4357
Fox LC, Scholl JL, Palmer GM, Forster GL, Watt MJ (2023) Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats. Exp Neurol 365:114415
Article PubMed CAS Google Scholar
Gendy AM, El-Sadek HM, Amin MM, Ahmed KA, El-Sayed MK, El-Haddad AE et al (2023) Glycyrrhizin prevents 3-nitropropionic acid-induced neurotoxicity by downregulating HMGB1/TLR4/NF-κB p65 signaling, and attenuating oxidative stress, inflammation, and apoptosis in rats. Life Sci 314:121317
Article PubMed CAS Google Scholar
Ghemrawi R, Khair M (2020) Endoplasmic reticulum stress and unfolded protein response in neurodegenerative diseases. Int J Mol Sci 21:1–25
Grant DA, Serpa R, Moattari CR, Brown A, Greco T, Prins ML et al (2018) Repeat mild traumatic brain injury in adolescent rats increases subsequent β-amyloid pathogenesis. J Neurotrauma 35:94–104
Article PubMed PubMed Central Google Scholar
Grilli M, Jason JS, Leonardo MJ (1993) NF-kappaB and rel-participants in a multiform transcriptional regulatory system. Int Rev Cytol 143:1–62
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