The Ubiquitin–Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers

Aberle H et al (1997) β-catenin is a target for the ubiquitin–proteasome pathway. The EMBO Journal 16(13):3797–3804

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abrishamdar M, Jalali MS, Rashno M (2022) MALAT1 lncRNA and Parkinson’s disease: the role in the pathophysiology and significance for diagnostic and therapeutic approaches. Mol Neurobiol 59(9):5253–5262

Article  CAS  PubMed  Google Scholar 

Abuznait AH et al (2013) Olive-oil-derived oleocanthal enhances beta-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci 4(6):973–982

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5(5):417–421

Article  CAS  PubMed  Google Scholar 

Adams J et al (1999) Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res 59(11):2615–2622

CAS  PubMed  Google Scholar 

Aghaizu ND, Jin H, Whiting PJ (2020) Dysregulated wnt signalling in the Alzheimer’s brain. Brain Sci. https://doi.org/10.3390/brainsci10120902

Article  PubMed  PubMed Central  Google Scholar 

Ahmad AS et al (2005) Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav 81(4):805–813

Article  CAS  PubMed  Google Scholar 

Akhtar A, Sah SP (2020) Insulin signaling pathway and related molecules: role in neurodegeneration and Alzheimer’s disease. Neurochem Int 135:104707

Article  CAS  PubMed  Google Scholar 

AlAbdi L et al (2023) Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects. Brain 146(4):1373–1387

Article  PubMed  Google Scholar 

Al-Awadhi FH et al (2020) Largazole is a brain-penetrant class I HDAC inhibitor with extended applicability to glioblastoma and CNS diseases. ACS Chem Neurosci 11(13):1937–1943

Article  CAS  PubMed  Google Scholar 

Alberini CM (2009) Transcription factors in long-term memory and synaptic plasticity. Physiol Rev 89(1):121–145

Article  CAS  PubMed  Google Scholar 

Aldewachi H et al (2021) High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases. Bioengineering. https://doi.org/10.3390/bioengineering8020030

Article  PubMed  PubMed Central  Google Scholar 

Aman Y et al (2021) Autophagy in healthy aging and disease. Nat Aging 1(8):634–650

Article  PubMed  PubMed Central  Google Scholar 

Amini A, Esmaeili F, Golpich M (2024) Possible role of lncRNAs in amelioration of Parkinson’s disease symptoms by transplantation of dopaminergic cells. NPJ Parkinsons Dis 10(1):56

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson HJ et al (1997) Cytotoxic peptides hemiasterlin, hemiasterlin A and hemiasterlin B induce mitotic arrest and abnormal spindle formation. Cancer Chemother Pharmacol 39(3):223–226

Article  CAS  PubMed  Google Scholar 

Anderson DJ et al (2015) Targeting the AAA ATPase p97 as an approach to treat cancer through disruption of protein homeostasis. Cancer Cell 28(5):653–665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ansari MA et al (2009) Protective effect of quercetin in primary neurons against Abeta(1–42): relevance to Alzheimer’s disease. J Nutr Biochem 20(4):269–275

Article  CAS  PubMed  Google Scholar 

Arkinson C et al (2025) Mechanisms and regulation of substrate degradation by the 26S proteasome. Nat Rev Mol Cell Biol 26(2):104–122

Article  CAS  PubMed  Google Scholar 

Arulvasub, C. and A.K. Rahiman, (n.d.) Magneto-structural correlation, antioxidant, DNA interaction and growth inhibition activities of new chloro-bridged phenolate complexes

Athanasopoulou S et al (2018) Beneficial effects of elderly tailored Mediterranean diet on the proteasomal proteolysis. Front Physiol 9:457

Article  PubMed  PubMed Central  Google Scholar 

Axelsson, V. (2006) Evaluation of neurotoxic properties of gliotoxin. Institutionen för neurokemi

Bagheri M et al (2011) Genistein ameliorates learning and memory deficits in amyloid beta(1–40) rat model of Alzheimer’s disease. Neurobiol Learn Mem 95(3):270–276

Article  CAS  PubMed  Google Scholar 

Balendra R, Isaacs AM (2018) C9orf72-mediated ALS and FTD: multiple pathways to disease. Nat Rev Neurol 14(9):544–558

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barker N (2014) Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration. Nat Rev Mol Cell Biol 15(1):19–33

Article  CAS  PubMed  Google Scholar 

Barrangou R, Marraffini LA (2014) CRISPR-Cas systems: prokaryotes upgrade to adaptive immunity. Mol Cell 54(2):234–244

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartlett C et al (2011) BRG1 mutations found in human cancer cell lines inactivate Rb-mediated cell-cycle arrest. J Cell Physiol 226(8):1989–1997

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baum L, Ng A (2004) Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models. J Alzheimers Dis 6(4):367–377

Article  CAS  PubMed  Google Scholar 

Baur JA et al (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444(7117):337–342

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bennett EJ et al (2007) Global changes to the ubiquitin system in Huntington’s disease. Nature 448(7154):704–708

Article  CAS  PubMed  Google Scholar 

Bhat KP et al (2014) Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proc Natl Acad Sci USA 111(15):5706–5711

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhat SA et al (2022) Ubiquitin proteasome system in immune regulation and therapeutics. Curr Opin Pharmacol 67:102310

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhat MA et al (2025) The E3 ubiquitin ligase MARCH1 mediates downregulation of plasma membrane GABAB receptors under ischemic conditions by inhibiting fast receptor recycling. Sci Rep 15(1):1330

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bingol B, Sheng M (2016) Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond. Free Radic Biol Med 100:210–222

Article  CAS 

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