Overloaded mitochondrial stress drives reproductive damage in GC-1 mouse spermatogonia cells exposed to nickel nanoparticle

Ai Y, Meng Y, Yan B, Zhou Q, Wang X. The biochemical pathways of apoptotic, necroptotic, pyroptotic, and ferroptotic cell death. Mol Cell. 2024;84:170–9.

Article  CAS  PubMed  Google Scholar 

Bhardwaj JK, Paliwal A, Saraf P. Effects of heavy metals on reproduction owing to infertility. J Biochem Mol Toxicol. 2021;35:e22823.

Article  CAS  PubMed  Google Scholar 

Bhardwaj JK, Siwach A, Sachdeva D, Sachdeva SN. Revisiting cadmium-induced toxicity in the male reproductive system: an update. Arch Toxicol. 2024;98:3619–39.

Article  CAS  PubMed  Google Scholar 

Eiyama A, Okamoto K. PINK1/Parkin-mediated mitophagy in mammalian cells. Curr Opin Cell Biol. 2015;33:95–101.

Article  CAS  PubMed  Google Scholar 

Hu W, Yu Z, Gao X, Wu Y, Tang M, Kong L. Study on the damage of sperm induced by nickel nanoparticle exposure. Environ Geochem Health. 2020;42:1715–24.

Article  CAS  PubMed  Google Scholar 

Iavicoli I, Leso V, Schulte PA. Biomarkers of susceptibility: state of the art and implications for occupational exposure to engineered nanomaterials. Toxicol Appl Pharmacol. 2016;299:112–24.

Article  CAS  PubMed  Google Scholar 

Iqbal S, Jabeen F, Chaudhry AS, Shah MA, Batiha GE-S. Toxicity assessment of metallic nickel nanoparticles in various biological models: an interplay of reactive oxygen species, oxidative stress, and apoptosis. Toxicol Ind Health. 2021;37:635–51.

Article  CAS  PubMed  Google Scholar 

Jaji N-D, Lee HL, Hussin MH, Akil HM, Zakaria MR, Othman MBH. Advanced nickel nanoparticles technology: from synthesis to applications. Nanotechnology Rev. 2020;9:1456–80.

Article  CAS  Google Scholar 

Jensen TK, Bonde JP, Joffe M. The influence of occupational exposure on male reproductive function. Occup Med. 2006;56:544–53.

Article  Google Scholar 

Jiang Y, Wang C, Ma L, Gao T, Wāng Y. Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone. Environ Int. 2024;187:108677.

Article  CAS  PubMed  Google Scholar 

Kamal R, Kumar V, Kumar R, Bhardwaj JK, Saraf P, Kumari P, et al. Design, synthesis, and screening of triazolopyrimidine-pyrazole hybrids as potent apoptotic inducers. Arch Pharm. 2017;350(11):1700137.

Article  Google Scholar 

Kanamori M, Oikawa K, Tanemura K, Hara K. Mammalian germ cell migration during development, growth, and homeostasis. Reprod Med Biol. 2019;18:247–55.

Article  PubMed  PubMed Central  Google Scholar 

Kong L, Tang M, Zhang T, Wang D, Hu K, Lu W, et al. Nickel nanoparticles exposure and reproductive toxicity in healthy adult rats. Int J Mol Sci. 2014;15:21253–69.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong L, Gao X, Zhu J, Cheng K, Tang M. Mechanisms involved in reproductive toxicity caused by nickel nanoparticle in female rats. Environ Toxicol. 2016;31:1674–83.

Article  CAS  PubMed  Google Scholar 

Kong L, Gao X, Zhu J, Zhang T, Xue Y, Tang M. Reproductive toxicity induced by nickel nanoparticles in Caenorhabditis elegans. Environ Toxicol. 2017;32:1530–8.

Article  CAS  PubMed  Google Scholar 

Kong L, Hu W, Gao X, Wu Y, Xue Y, Cheng K, et al. Molecular mechanisms underlying nickel nanoparticle induced rat Sertoli-germ cells apoptosis. Sci Total Environ. 2019a;692:240–8.

Article  CAS  PubMed  Google Scholar 

Kong L, Hu W, Lu C, Cheng K, Tang M. Mechanisms underlying nickel nanoparticle induced reproductive toxicity and chemo-protective effects of vitamin C in male rats. Chemosphere. 2019b;218:259–65.

Article  CAS  PubMed  Google Scholar 

Kong L, Dong J, Lu W, Wu Y, Liu L, Tang M. Exposure effects of inhaled nickel nanoparticles on the male reproductive system via mitochondria damage. NanoImpact. 2021a;23:100350.

Article  CAS  PubMed  Google Scholar 

Kong L, Wu Y, Hu W, Liu L, Xue Y, Liang G. Mechanisms underlying reproductive toxicity induced by nickel nanoparticles identified by comprehensive gene expression analysis in GC-1 spg cells. Environ Pollut. 2021b;275:116556.

Article  CAS  PubMed  Google Scholar 

Kong L, Dong J, Wāng Y. Mitochondrial homeostasis via Pink1 control alleviates nickel nanoparticle-induced reproductive damage in mouse spermatocyte GC-2 cells. Environ Int. 2025;206:109910.

Article  CAS  PubMed  Google Scholar 

Kubli DA, Gustafsson ÅB. Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res. 2012;111:1208–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar S. Occupational exposure associated with reproductive dysfunction. J Occup Health. 2004;46:1–19.

Article  CAS  PubMed  Google Scholar 

Levine H, Jørgensen N, Martino-Andrade A, Mendiola J, Weksler-Derri D, Jolles M, et al. Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries. Hum Reprod Update. 2023;29:157–76.

Article  PubMed  Google Scholar 

Liu L, Kong L. Research progress on the carcinogenicity of metal nanomaterials. J Appl Toxicol. 2021;41:1334–44.

Article  CAS  PubMed  Google Scholar 

Liu N, Tang M. Toxic effects and involved molecular pathways of nanoparticles on cells and subcellular organelles. J Appl Toxicol. 2020;40:16–36.

Article  PubMed  Google Scholar 

Liu L, Lu W, Dong J, Wu Y, Tang M, Liang G, et al. Study of the mechanism of mitochondrial division and mitochondrial autophagy in the male reproductive toxicity induced by nickel nanoparticles. Nanoscale. 2022a;14:1868–84.

Article  CAS  PubMed  Google Scholar 

Liu M, Wang B, Cui Y, Xiao B, Liu P, Gao J, et al. Pink1/Parkin-mediated mitophagy is activated to protect against testicular damage caused by aluminum. J Inorg Biochem. 2022b;232:111840.

Article  CAS  PubMed  Google Scholar 

Mo Y, Jiang M, Zhang Y, Wan R, Li J, Zhong CJ, et al. Comparative mouse lung injury by nickel nanoparticles with differential surface modification. J Nanobiotechnol. 2019;17:2.

Article  Google Scholar 

Mo Y, Zhang Y, Zhang Y, Yuan J, Mo L, Zhang Q. Nickel nanoparticle-induced cell transformation: involvement of DNA damage and DNA repair defect through HIF-1α/miR-210/Rad52 pathway. J Nanobiotechnol. 2021;19:370.

Article  CAS  Google Scholar 

Mo Y, Zhang Y, Zhang Q. The pulmonary effects of nickel-containing nanoparticles: cytotoxicity, genotoxicity, carcinogenicity, and their underlying mechanisms. Environ Sci Nano. 2024;11:1817–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

More SL, Kovochich M, Lyons-Darden T, Taylor M, Schulte AM, Madl AK. Review and evaluation of the potential health effects of oxidic nickel nanoparticles. Nanomaterials. 2021;11:642.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen TN, Padman BS, Lazarou M. Deciphering the molecular signals of PINK1/Parkin mitophagy. Trends Cell Biol. 2016;26:733–44.

Article  CAS  PubMed  Google Scholar 

Panchal H, Bhardwaj JK. Quercetin supplementation alleviates cadmium induced genotoxici

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