This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2022R1C1C1007544, 2024M3A9H5043152 to SL), a grant from the Korea Drug Development Fund funded by the Ministry of Science and ICT, the Ministry of Trade, Industry, and Energy, and the Ministry of Health and Welfare (RS-2025-02222987 to SL), a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (RS-2025-25459955 to SL), a grant from the Korean ARPA-H Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (RS-2025-2542273 to SL), and the Institute for Basic Science (IBS), Republic of Korea (IBS-R801--D9-A09, IBS-R801-D1-2025-a02 to SL). Additionally, this study received funding from the Republic of Korea’s National Institute of Health (Project No. #2025ER160200, #2025ER240100 to SL).