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Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages
Tofacitinib repairs inflammation and mitochondrial dysregulation in GM-CSF-reprogrammed RA macrophages
Rheumatoid arthritis (RA) exhibits heterogeneous endotypes, complicating treatment strategies. GM-CSF and GM-CSFRα ar...
RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution
RNA-binding proteins Zfp36l1 and Zfp36l2 protect against premature thymic involution
The thymus is a primary lymphoid organ in which diverse and self-tolerant T cells are produced from bone marrow-derived he...
The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages
The type-I interferon priming signal balances antibacterial and antitumor trained immunity in alveolar macrophages
Tissue-resident macrophages may be trained to confer an enhanced response to heterologous restimulation and thus foster ve...
Reprogramming the immune orchestra for glioblastoma: oncolytic viruses and the B-cell connection
Reprogramming the immune orchestra for glioblastoma: oncolytic viruses and the B-cell connection
Glioblastoma multiforme (GBM) is a lethal primary brain cancer for which tre...
Ferroptosis shapes ILC2 responses in inflammatory bowel disease
Ferroptosis shapes ILC2 responses in inflammatory bowel disease
Escuder-Rodriguez JJ, Liang D, Jiang X, Sinicrope FA. Ferroptosis: biology and role in gastrointestinal disease. Gastroent...
B cells help cross-priming antiviral CD8⁺ T cells
B cells help cross-priming antiviral CD8⁺ T cells
Upasani V, Rodenhuis-Zybert I, Cantaert T. Antibody-independent functions of B cells during viral infections. PLoS Pathog....
Mechanistic impasses: tofacitinib treatment ameliorates GM-CSF-driven macrophage inflammation
Mechanistic impasses: tofacitinib treatment ameliorates GM-CSF-driven macrophage inflammation
Satoeya N, Zack SR, Zoubi OA, Umar S, Burgos A, Abdulrab S, et al. Tofacitinib repairs inflammation and mitochondrial dysr...
Defining lytic IFNγ for deciphering the CTL mechanism
Defining lytic IFNγ for deciphering the CTL mechanism
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (2022...
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
CD8+GZMK+CD27+CCR7+ T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells
Splenic sympathetic activity critically modulates peripheral immunity after ischemic stroke, thus intervention in spleen s...
Notch2−expressing CD4+ T cells attain immunoregulatory functions during autoimmune inflammation
Notch2−expressing CD4+ T cells attain immunoregulatory functions during autoimmune inflammation
Autoantigen−specific CD4+ T cells are central to the development of autoimmune diseases, while the expansion of regu...
Myeloid cells in chronic liver inflammation
Myeloid cells in chronic liver inflammation
Chronic liver disease represents a significant global health burden. Regardless of etiology, its pathogenesis is driven by...
PANoptosis in cancer: bridging molecular mechanisms to therapeutic innovations
PANoptosis in cancer: bridging molecular mechanisms to therapeutic innovations
PANoptosis, a newly defined inflammatory programmed cell death, plays key roles in tumor development and progression. This...
Provocation and palliation—the dual roles of dermal white adipose tissue in neutrophilic skin inflammation
Provocation and palliation—the dual roles of dermal white adipose tissue in neutrophilic skin inflammation
Psoriasis and other inflammatory skin diseases remain challenging to manage, in part owing to an incomplete understanding ...
The gut microbiota in cancer immunity and immunotherapy
The gut microbiota in cancer immunity and immunotherapy
The human gastrointestinal tract harbors trillions of microorganisms, including bacteria, fungi, and viruses, to form the ...
Immunoglobulin divalence promotes B-cell antigen receptor cluster scale-dependent functions
Immunoglobulin divalence promotes B-cell antigen receptor cluster scale-dependent functions
Antibodies, also known as immunoglobulins, share an evolutionarily conserved dimeric core structure with two antigen bindi...
Author Correction: Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin
Children exhibit a robust B-cell response to Omicron BA.2 after breakthrough infection with limited influence from the original antigenic sin
Dowell AC, Lancaster T, Bruton R, Ireland G, Bentley C, Sylla P, et al. Immunological imprinting of humoral immunity to SA...
The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling
The antitumor activity of TGFβ-specific T cells is dependent on IL-6 signaling
Although interleukin (IL)-6 is considered immunosuppressive and tumor-promoting, emerging evidence suggests that it may su...
Neutrophils in cancer: from biology to therapy
Neutrophils in cancer: from biology to therapy
The view of neutrophils has shifted from simple phagocytic cells, whose main function is to kill pathogens, to very comple...
Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling
Esophageal ILC2s mediate abnormal epithelial remodeling in eosinophilic esophagitis via Areg-EGFR signaling
Eosinophilic esophagitis (EoE) is a chronic allergic disorder characterized by eosinophilia and epithelial thickening, res...
Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
Immunogenicity of cell death and cancer immunotherapy with immune checkpoint inhibitors
While immunotherapy with immune checkpoint inhibitors (ICIs) has revolutionized the clinical management of various maligna...
Effective immunosurveillance of clonally expanded mammary aneuploid cells
Effective immunosurveillance of clonally expanded mammary aneuploid cells
The LG lab is/has been supported (as a PI unless otherwise indicated) by one NIH R01 grant (#CA271915), by two Breakthroug...
MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH
MYO1F regulates T-cell activation and glycolytic metabolism by promoting the acetylation of GAPDH
Proper cellular metabolism in T cells is critical for a productive immune response. However, when dysregulated by intrinsi...
A special RELationship between sugar and tumor-infiltrating regulatory T cells
A special RELationship between sugar and tumor-infiltrating regulatory T cells
In this context of Cellular and Molecular Immunology, Sharma and coworkers r...
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation
The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the immunosuppressive tumor microenv...
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment
A highly immunosuppressive tumor microenvironment (TME) and the presence of the blood‒brain barrier are the two majo...
Interleukin-10 multitasking in allergic airway inflammation
Interleukin-10 multitasking in allergic airway inflammation
Papi A, Brightling C, Pedersen SE, Reddel HK. Asthma. Lancet. 2018;391:783–800.Article  PubMed  ...
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
A tumor-associated heparan sulfate-related glycosaminoglycan promotes the generation of functional regulatory T cells
Functional Tregs play a key role in tumor development and progression, representing a major barrier to anticancer immunity...
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24
Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare autosomal recessive disorder char...
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Inflammasomes are important sentinels of innate immune defense; they sense pathogens and induce the cell death of infected...
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