Tafolla M, Singer H, Lord C. Autism spectrum disorder across the lifespan. Annu Rev Clin Psychol 2025, 21: 193–220.

Article  PubMed  Google Scholar 

Hirota T, King BH. Autism spectrum disorder: A review. JAMA 2023, 329: 157–168.

Article  PubMed  CAS  Google Scholar 

Zhou H, Xu X, Yan W, Zou X, Wu L, Luo X. Prevalence of autism spectrum disorder in China: A nationwide multi-center population-based study among children aged 6 to 12 years. Neurosci Bull 2020, 36: 961–971.

Article  PubMed  PubMed Central  Google Scholar 

Jiang X, Chen X, Su J, Liu N. Prevalence of autism spectrum disorder in mainland China over the past 6 years: A systematic review and meta-analysis. BMC Psychiatry 2024, 24: 404.

Article  PubMed  PubMed Central  Google Scholar 

Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J. Autism spectrum disorder. Lancet 2018, 392: 508–520.

Article  PubMed  PubMed Central  Google Scholar 

de Lima TA, Zuanetti PA, Nunes MEN, Hamad APA. Differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period. World J Pediatr 2023, 19: 715–726.

Article  PubMed  Google Scholar 

Yuan B, Wang M, Wu X, Cheng P, Zhang R, Zhang R, et al. Identification of de novo mutations in the Chinese autism spectrum disorder cohort via whole-exome sequencing unveils brain regions implicated in autism. Neurosci Bull 2023, 39: 1469–1480.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ronemus M, Iossifov I, Levy D, Wigler M. The role of de novo mutations in the genetics of autism spectrum disorders. Nat Rev Genet 2014, 15: 133–141.

Article  PubMed  CAS  Google Scholar 

Cheroni C, Caporale N, Testa G. Autism spectrum disorder at the crossroad between genes and environment: Contributions, convergences, and interactions in ASD developmental pathophysiology. Mol Autism 2020, 11: 69.

Article  PubMed  PubMed Central  Google Scholar 

Love C, Sominsky L, O’Hely M, Berk M, Vuillermin P, Dawson SL. Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms. BMC Med 2024, 22: 393.

Article  PubMed  PubMed Central  Google Scholar 

Antoine MW, Langberg T, Schnepel P, Feldman DE. Increased excitation-inhibition ratio stabilizes synapse and circuit excitability in four autism mouse models. Neuron 2019, 101: 648-661.e4.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sohal VS, Rubenstein JLR. Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders. Mol Psychiatry 2019, 24: 1248–1257.

Article  PubMed  PubMed Central  Google Scholar 

Khaliulin I, Hamoudi W, Amal H. The multifaceted role of mitochondria in autism spectrum disorder. Mol Psychiatry 2025, 30: 629–650.

Article  PubMed  CAS  Google Scholar 

Schuler MH, English AM, Xiao T, Campbell TJ, Shaw JM, Hughes AL. Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress. Mol Cell 2021, 81: 3786-3802.e13.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hughes JV, Johnson TC. Abnormal amino acid metabolism and brain protein synthesis during neural development. Neurochem Res 1978, 3: 381–399.

Article  PubMed  Google Scholar 

Polis B, Samson AO. Role of the metabolism of branched-chain amino acids in the development of Alzheimer’s disease and other metabolic disorders. Neural Regen Res 2020, 15: 1460–1470.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kimura H. Signaling molecules: Hydrogen sulfide and polysulfide. Antioxid Redox Signal 2015, 22: 362–376.

Article  PubMed  CAS  Google Scholar 

Boehning D, Snyder SH. Novel neural modulators. Annu Rev Neurosci 2003, 26: 105–131.

Article  PubMed  CAS  Google Scholar 

Kimura H. Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int 2013, 63: 492–497.

Article  PubMed  CAS  Google Scholar 

Dogaru BG, Munteanu C. The role of hydrogen sulfide (H(2)S) in epigenetic regulation of neurodegenerative diseases: A systematic review. Int J Mol Sci 2023, 24: 12555.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo BQ, Li HB, Ding SB. Blood homocysteine levels in children with autism spectrum disorder: An updated systematic review and meta-analysis. Psychiatry Res 2020, 291: 113283.

Article  PubMed  CAS  Google Scholar 

Xian P, Wang M, Xie R, Ma H, Zheng W, Kang J, et al. Mitochondrial dysfunction reveals H(2)S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects. Cell Metab 2025, 37: 2076-2092.e8.

Article  PubMed  CAS  Google Scholar 

Zheng WA, Wang M, Cui Y, Xu Q, Chen Y, Xian P, et al. Establishment of a two-hit mouse model of environmental factor induced autism spectrum disorder. Heliyon 2024, 10: e30617.

Article  PubMed  PubMed Central  Google Scholar 

Ma H, Cui Z, Guo X, Zhao Q, Zhang Y, Guan Y, et al. Corticotropin-releasing factor potentiates glutamatergic input and excitability of presympathetic neurons in the hypothalamus in spontaneously hypertensive rats. Neuropharmacology 2023, 230: 109506.

Article  PubMed  CAS  Google Scholar 

Varghese M, Keshav N, Jacot-Descombes S, Warda T, Wicinski B, Dickstein DL, et al. Autism spectrum disorder: Neuropathology and animal models. Acta Neuropathol 2017, 134: 537–566.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen JA, Peñagarikano O, Belgard TG, Swarup V, Geschwind DH. The emerging picture of autism spectrum disorder: Genetics and pathology. Annu Rev Pathol 2015, 10: 111–144.

Article  PubMed  CAS  Google Scholar 

Frye RE, Rincon N, McCarty PJ, Brister D, Scheck AC, Rossignol DA. Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis. Neurobiol Dis 2024, 197: 106520.

Article  PubMed  CAS  Google Scholar 

Castora FJ. Mitochondrial function and abnormalities implicated in the pathogenesis of ASD. Prog Neuropsychopharmacol Biol Psychiatry 2019, 92: 83–108.

Article  PubMed  CAS  Google Scholar 

Frye RE. Mitochondrial dysfunction in autism spectrum disorder: Unique abnormalities and targeted treatments. Semin Pediatr Neurol 2020, 35: 100829.

Article  PubMed  Google Scholar 

Paul BD, Snyder SH, Kashfi K. Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics. Redox Biol 2021, 38: 101772.

Article  PubMed  CAS  Google Scholar 

Zhang X, Xin Y, Chen Z, Xia Y, Xun L, Liu H. Sulfide-quinone oxidoreductase is required for cysteine synthesis and indispensable to mitochondrial health. Redox Biol 2021, 47: 102169.

Article  PubMed