Preparatory Activity Indexes Motor Memory in the Motor Cortex

Churchland MM, Cunningham JP, Kaufman MT, Ryu SI, Shenoy KV. Cortical preparatory activity: Representation of movement or first cog in a dynamical machine? Neuron 2010, 68: 387–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Liu Y, Wang ZA, Colonell J, Liu LD, Hou H. Brain-wide neural activity underlying memory-guided movement. Cell 2024, 187: 676-691.e16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davare M, Andres M, Cosnard G, Thonnard JL, Olivier E. Dissociating the role of ventral and dorsal premotor cortex in precision grasping. J Neurosci 2006, 26: 2260–2268.

Article  PubMed  PubMed Central  Google Scholar 

Shinotsuka T, Tanaka YR, Terada SI, Hatano N, Matsuzaki M. Layer 5 intratelencephalic neurons in the motor cortex stably encode skilled movement. J Neurosci 2023, 43: 7130–7148.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richardson AG, Overduin SA, Valero-Cabre A, Padoa-Schioppa C, Pascual-Leone A, Bizzi E, et al. Disruption of primary motor cortex before learning impairs memory of movement dynamics. J Neurosci 2006, 26: 12466–12470.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun X, O’Shea DJ, Golub MD, Trautmann EM, Vyas S, Ryu SI, et al. Cortical preparatory activity indexes learned motor memories. Nature 2022, 602: 274–279.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JH, Daie K, Li N. A combinatorial neural code for long-term motor memory. Nature 2025, 637: 663–672.

Article  CAS  PubMed  Google Scholar 

Kamigaki T, Dan Y. Delay activity of specific prefrontal interneuron subtypes modulates memory-guided behavior. Nat Neurosci 2017, 20: 854–863.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makino H, Ren C, Liu H, Kim AN, Kondapaneni N, Liu X, et al. Transformation of cortex-wide emergent properties during motor learning. Neuron 2017, 94: 880-890.e8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gallego JA, Perich MG, Chowdhury RH, Solla SA, Miller LE. Long-term stability of cortical population dynamics underlying consistent behavior. Nat Neurosci 2020, 23: 260–270.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, Chen TW, Guo ZV, Gerfen CR, Svoboda K. A motor cortex circuit for motor planning and movement. Nature 2015, 519: 51–56.

Article  CAS  PubMed  Google Scholar 

Li N, Daie K, Svoboda K, Druckmann S. Robust neuronal dynamics in premotor cortex during motor planning. Nature 2016, 532: 459–464.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michaels JA, Kashefi M, Zheng J, Codol O, Weiler J, Kersten R, et al. Sensory expectations shape neural population dynamics in motor circuits. Nature 2025, 648: 668–677.

Article  CAS  PubMed  Google Scholar 

Vyas S, O’Shea DJ, Ryu SI, Shenoy KV. Causal role of motor preparation during error-driven learning. Neuron 2020, 106: 329-339.e4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meirhaeghe N, Riehle A, Brochier T. Parallel movement planning is achieved via an optimal preparatory state in motor cortex. Cell Rep 2023, 42: 112136.

Article  CAS  PubMed  Google Scholar 

Paz R, Boraud T, Chen N, Bergman H, Vaadia E. Preparatory activity in motor cortex reflects learning of local visuomotor skills. Nat Neurosci 2003, 6: 882–890.

Article  CAS  PubMed  Google Scholar 

Omrani M, Kaufman MT, Hatsopoulos NG, Cheney PD. Perspectives on classical controversies about the motor cortex. J Neurophysiol 2017, 118: 1828–1848.

Article  PubMed  PubMed Central  Google Scholar 

Fridman EA, Hanakawa T, Chung M, Hummel F, Leiguarda RC, Cohen LG. Reorganization of the human ipsilesional premotor cortex after stroke. Brain 2004, 127: 747–758.

Article  PubMed  Google Scholar 

Lu Y, Lin Z, Li M, Zhuang Y, Nie B, Lei J, et al. Three-phase enriched environment improves post-stroke gait dysfunction via facilitating neuronal plasticity in the bilateral sensorimotor cortex: A multimodal MRI/PET analysis in rats. Neurosci Bull 2024, 40: 719–731.

Article  CAS  PubMed  Google Scholar 

Liao WY, Opie GM, Ziemann U, Semmler JG. Modulation of dorsal premotor cortex differentially influences I-wave excitability in primary motor cortex of young and older adults. J Physiol 2023, 601: 2959–2974.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif