Poulter NR, Prabhakaran D, Caulfield M, Hypertension. Lancet. 2015;386(9995):801–12.

Article  PubMed  Google Scholar 

Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52.

Article  PubMed  Google Scholar 

Geldsetzer P, Manne-Goehler J, Marcus ME, Ebert C, Zhumadilov Z, Wesseh CS, et al. The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults. Lancet. 2019;394(10199):652–62.

Article  PubMed  Google Scholar 

Egan BM, Zhao Y, Axon RN. US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. JAMA. 2010;303(20):2043–50.

Article  CAS  PubMed  Google Scholar 

Chow CK, Teo KK, Rangarajan S, Islam S, Gupta R, Avezum A, et al. Prevalence, awareness, treatment, and control of hypertension in rural and urban communities in high-, middle-, and low-income countries. JAMA. 2013;310(9):959–68.

Article  CAS  PubMed  Google Scholar 

Tocci G, Nati G, Cricelli C, Parretti D, Lapi F, Ferrucci A, et al. Prevalence and control of hypertension in the general practice in italy: updated analysis of a large database. J Hum Hypertens. 2017;31(4):258–62.

Article  CAS  PubMed  Google Scholar 

(NCD-RisC) NRFC. Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys. Lancet. 2019;394(10199):639–51.

Article  Google Scholar 

Mancia G, Zambon A, Soranna D, Merlino L, Corrao G. Factors involved in the discontinuation of antihypertensive drug therapy: an analysis from real life data. J Hypertens. 2014;32(8):1708–15. discussion 16.

Article  CAS  PubMed  Google Scholar 

Tocci G, Presta V, Citoni B, Figliuzzi I, Bianchi F, Ferrucci A, et al. Blood pressure target achievement under monotheraphy: a Real-Life appraisal. High Blood Press Cardiovasc Prev. 2020;27(6):587–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Del Pinto R, Agabiti Rosei C, Borghi C, Cipollini F, Cottone S, De Giorgi GA, et al. May measure month 2022 in italy: A focus on Fixed-dose Combination, therapeutic Adherence, and medical inertia in a nationwide survey. High Blood Press Cardiovasc Prev 2024;31(3):309–320

Cicero AFG, Fogacci F, Tocci G, Ventura F, Presta V, Grandi E, et al. Awareness of major cardiovascular risk factors and its relationship with markers of vascular aging: data from the Brisighella heart study. Nutr Metab Cardiovasc Dis. 2020;30(6):907–14.

Article  CAS  PubMed  Google Scholar 

Tocci G, Muiesan ML, Parati G, Agabiti Rosei E, Ferri C, Virdis A, et al. Trends in prevalence, awareness, treatment, and control of blood pressure recorded from 2004 to 2014 during world hypertension day in Italy. J Clin Hypertens (Greenwich). 2016;18(6):551–6.

Article  PubMed  Google Scholar 

Rea F, Corrao G, Merlino L, Mancia G. Initial antihypertensive treatment strategies and therapeutic inertia. Hypertension. 2018;72(4):846–53.

Article  CAS  PubMed  Google Scholar 

Corrao G, Parodi A, Nicotra F, Zambon A, Merlino L, Cesana G, et al. Better compliance to antihypertensive medications reduces cardiovascular risk. J Hypertens. 2011;29(3):610–8.

Article  CAS  PubMed  Google Scholar 

Volpe M, Rosei EA, Ambrosioni E, Cottone S, Cuspidi C, Borghi C, et al. 2012 consensus document of the Italian society of hypertension (SIIA): strategies to improve blood pressure control in italy: from global cardiovascular risk stratification to combination therapy. High Blood Press Cardiovasc Prev. 2013;20(1):45–52.

Article  CAS  PubMed  Google Scholar 

Mancia Chairperson G, Kreutz Co-Chair R, Brunström M, Burnier M, Grassi G, Januszewicz A et al. 2023 ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European society of hypertension endorsed by the European renal association (ERA) and the international society of hypertension (ISH). J Hypertens. 2023;41(12):1874–2071.

McEvoy JW, McCarthy CP, Bruno RM, Brouwers S, Canavan MD, Ceconi C, et al. 2024 ESC guidelines for the management of elevated blood pressure and hypertension. Eur Heart J. 2024;45(38):3912–4018.

Article  PubMed  Google Scholar 

Jones DW, Ferdinand KC, Taler SJ, Johnson HM, Shimbo D, Abdalla M, AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC et al. /NMA/PCNA/SGIM Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults: a Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Hypertension. 2025;152:e114–e218.

Vrints C, Andreotti F, Koskinas KC, Rossello X, Adamo M, Ainslie J, et al. 2024 ESC guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415–537.

Article  CAS  PubMed  Google Scholar 

Volpe M, Tocci G. Redefining blood pressure targets in high-risk patients? Lessons from coronary endpoints in recent randomized clinical trials. Am J Hypertens. 2011;24(10):1060–8.

Article  CAS  PubMed  Google Scholar 

Collaboration BPLTT. Pharmacological blood pressure Lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. Lancet. 2021;397(10285):1625–36.

Article  Google Scholar 

Arguedas JA, Leiva V, Wright JM. Blood pressure targets in adults with hypertension. Cochrane Database Syst Rev. 2020;12(12):CD004349.

PubMed  PubMed Central  Google Scholar 

Baffour-Awuah B, Dieberg G, Pearson MJ, Smart NA. Blood pressure control in older adults with hypertension: a systematic review with meta-analysis and meta-regression. Int J Cardiol Hypertens. 2020;6:100040.

Article  PubMed  PubMed Central  Google Scholar 

Verdecchia P, Angeli F, Cavallini C, Mazzotta G, Garofoli M, Martire P, et al. The optimal blood pressure target for patients with coronary artery disease. Curr Cardiol Rep. 2010;12(4):302–6.

Article  PubMed  Google Scholar 

Vidal-Petiot E, Ford I, Greenlaw N, Ferrari R, Fox KM, Tardif JC, et al. Cardiovascular event rates and mortality according to achieved systolic and diastolic blood pressure in patients with stable coronary artery disease: an international cohort study. Lancet. 2016;388(10056):2142–52.

Article  PubMed  Google Scholar 

Kamishima K, Ogawa H, Jujo K, Yamaguchi J, Hagiwara N. Relationships between blood pressure Lowering therapy and cardiovascular events in hypertensive patients with coronary artery disease and type 2 diabetes mellitus: the HIJ-CREATE sub-study. Diabetes Res Clin Pract. 2019;149:69–77.

Article  CAS  PubMed  Google Scholar 

collaboration SwgaECr. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe. Eur Heart J. 2021;42(25):2439–54.

Article  Google Scholar 

collaboration S-OwgaECr. SCORE2-OP risk prediction algorithms: estimating incident cardiovascular event risk in older persons in four geographical risk regions. Eur Heart J. 2021;42(25):2455–67.

Article  Google Scholar 

Collaboration S-DWGECR. SCORE2-Diabetes: 10-year cardiovascular risk Estimation in type 2 diabetes in Europe. Eur Heart J. 2023;44(28):2544–56.

Article  Google Scholar 

Major outcomes in. high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: the antihypertensive and Lipid-Lowering treatment to prevent heart attack trial (ALLHAT). JAMA. 2002;288(23):2981–97.

Article  Google Scholar 

Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding Perindopril as required versus Atenolol adding Bendroflumethiazide as required, in the Anglo-Scandinavian cardiac outcomes Trial-Blood pressure Lowering arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet. 2005;366(9489):895–906.

Article  PubMed  Google Scholar 

Jamerson K, Weber MA, Bakris GL, Dahlof B, Pitt B, Shi V, et al. Benazepril plus amlodipine or Hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359(23):2417–28.

Article  CAS  PubMed  Google Scholar 

Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122(3):290–300.

Article  PubMed  Google Scholar 

Law MR, Wald NJ, Morris JK, Jordan RE. Value of low dose combination treatment with blood pressure Lowering drugs: analysis of 354 randomised trials. BMJ. 2003;326(7404):1427.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park S, Shin ES, Ihm SH, Lee HY. Optimizing systolic blood pressure targets for elderly hypertensive patients: a meta-analysis of mortality, cardiovascular outcomes, and adverse events. Clin Hypertens. 2025;31:e25.

Article  PubMed