The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling

Cai K, Zhang W, Su S, Yan H, Liu H, Zhu Y, Shang E, Guo S et al (2024) Salvia miltiorrhiza stem-leaf of total phenolic acid conversion products alleviate myocardial ischemia by regulating metabolic profiles, intestinal microbiota and metabolites. Biomed Pharmacother 177:117055. https://doi.org/10.1016/j.biopha.2024.117055

Cai Z, Luo Q, Yang X, Pu L, Zong H, Shi R, He P, Xu Y et al (2023) Overloaded axial stress activates the Wnt/β-Catenin pathway in nucleus pulposus cells of adult degenerative scoliosis combined with intervertebral disc degeneration. Mol Biol Rep 50(6):4791–4798. https://doi.org/10.1007/s11033-023-08390-9

Chang X, Cao Y, Hu ZL, Zhai Y, Zhang YY, Lv YF, Li CQ (2024) PHLDA2 overexpression facilitates senescence and apoptosis via the mitochondrial route in human nucleus pulposus cells by regulating Wnt/β-catenin signalingsignalling pathway. IUBMB Life 2024 76(10):788–802. https://doi.org/10.1002/iub.2829

Chen BA, Deng WC, Chen MY (2022) Acupuncture for pain control after degenerative lumbar spine surgery. Eur J Med Res 27(1):167. https://doi.org/10.1186/s40001-022-00797-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Deng Z, Yu Z, Chen Y, Yu T, Liang C, Ye Y, Huang Y et al (2024) The role of melatonergic system in intervertebral disc degeneration and its association with low back pain: a clinical study. PeerJ 12:e17464. https://doi.org/10.7717/peerj.17464

Ding L, Jiang Z, Wu J, Li D, Wang H, Lu W, Zeng Q, Xu G (2019) β-catenin signalling inhibits cartilage endplate chondrocyte homeostasis in vitro. Mol Med Rep 20(1):567–572. https://doi.org/10.3892/mmr.2019.10301

Fan Q, Wu H, Kong Q (2022) Superhydrophilic PLGA-graft-PVP/PC nanofiber membranes for the prevention of epidural adhesion. Int J Nanomed 17:1423–1435. https://doi.org/10.2147/ijn.S356250

Article  Google Scholar 

Gajos-Michniewicz A, Czyz M (2020) WNT signaling in melanoma. Int J Mol Sci 21(14):4852. https://doi.org/10.3390/ijms21144852

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo S, Ren Y, Chang R, He Y, Zhang D, Guan F, Yao M (2022) Injectable self-healing adhesive chitosan hydrogel with antioxidative, antibacterial, and hemostatic activities for rapid hemostasis and skin wound healing. ACS Appl Mater Interfaces 14(30):34455–34469

Jovanovic M, Marini JC (2024) Update on the genetics of Osteogenesis Imperfecta. Calcif Tissue Int. https://doi.org/10.1007/s00223-024-01266-5

Article  PubMed  PubMed Central  Google Scholar 

Kondo N, Yuasa T, Shimono K, Tung W, Okabe T, Yasuhara R, Pacifici M, Zhang Y et al (2011) Intervertebral disc development is regulated by Wnt/β-catenin signaling. Spine (Phila Pa 1976) 36(8):E513–518. https://doi.org/10.1097/BRS.0b013e3181f52cb5

Li R, Li W, Yao X (2024) The efficacy of gabapentin supplementation for pain control after lumbar laminectomy and discectomy: a meta-analysis study. Med 103(25):e37908. https://doi.org/10.1097/MD.0000000000037908

Article  Google Scholar 

Li Z, Cai F, Tang J, Xu Y, Guo K, Xu Z, Feng Y, Xi K et al (2023) Oxygen metabolism-balanced engineered hydrogel microspheres promote the regeneration of the nucleus pulposus by inhibiting acid-sensitive complexes. Bioact Mater 24:346–360. https://doi.org/10.1016/j.bioactmat.2022.12.025

Lorzadeh S, Kohan L, Ghavami S, Azarpira N (2021) Autophagy and the Wnt signaling pathway: a focus on Wnt/β-catenin signaling. Biochim Biophys Acta Mol Cell Res 1868(3):118926. https://doi.org/10.1016/j.bbamcr.2020.118926

Article  CAS  PubMed  Google Scholar 

Maleki Dana P, Hallajzadeh J, Asemi Z, Mansournia MA, Yousefi B (2021) Chitosan applications in studying and managing osteosarcoma. Int J Biol Macromol 169:321–329. https://doi.org/10.1016/j.ijbiomac.2020.12.058

Article  CAS  PubMed  Google Scholar 

McCann MR, Séguin CA (2016) Notochord cells in intervertebral disc development and degeneration. J Dev Biol 4(1):3. https://doi.org/10.3390/jdb4010003

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oichi T, Taniguchi Y, Oshima Y, Tanaka S, Saito T (2020) Pathomechanism of intervertebral disc egeneration. JOR Spine 3(1):e1076. https://doi.org/10.1002/jsp2.1076

Article  PubMed  PubMed Central  Google Scholar 

Peene L, Le Cacheux P, Sauter AR, Joshi GP, Beloeil H, Collaborators P W G (2021) Pain management after laminectomy: a systematic review and procedure-specific post-operative pain management (PROSPECT) recommendations. Eur Spine J 30(10):2925–2935. https://doi.org/10.1007/s00586-020-06661-8

Article  PubMed  Google Scholar 

Raoufi S, Baluchnejadmojarad T, Roghani M, Ghazanfari T, Khojasteh F, Mansouri M (2015) Antidiabetic potential of salvianolic acid B in multiple low-dose streptozotocin-induced diabetes. Pharm Biol 53(12):180318–180409. https://doi.org/10.3109/13880209.2015.1008148

Article  CAS  Google Scholar 

Routledge D, Scholpp S (2019) Mechanisms of intercellular Wnt transport. Development 146(10):dev176073. https://doi.org/10.1242/dev.176073

Article  CAS  PubMed  Google Scholar 

Sae-Jung S, Jirarattanaphochai K (2013) Prevention of peridural fibrosis using a cyclooxygenase-2 inhibitor (nonsteroidal anti-inflammatory drug) soaked in absorbable gelatin sponge: an experimental comparative animal model. Spine 38(16):E985-991. https://doi.org/10.1097/BRS.0b013e318297c795

Article  PubMed  Google Scholar 

Sandoval MA, Hernandez-Vaquero D (2008) Preventing peridural fibrosis with nonsteroidal anti-inflammatory drugs. Eur Spine J 17(3):451–455. https://doi.org/10.1007/s00586-007-0580-y

Article  PubMed  PubMed Central  Google Scholar 

Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang CW, Oginuma M, Saga Y et al (2009) Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord. Mech Dev 126(10):791–803. https://doi.org/10.1016/j.mod.2009.08.003

Vediappan RS, Mascarenhas A, Nguyen-Hoang A, Anne Fong S, Jukes A, Richter K, Bassiouni A, Patel S et al (2020) Prevention of peridural adhesions in spinal surgery: assessing safety and efficacy of Chitogel with deferiprone in a sheep model. J Clin Neurosci 72:378–385. https://doi.org/10.1016/j.jocn.2019.12.042

Xu Y, He J, He J (2022) Cyanidin attenuates the high hydrostatic pressure-induced degradation of cellular matrix of nucleus pulposus cell by blocking via blocking the Wnt/β-catenin signaling. Tissue Cell 76:101798. https://doi.org/10.1016/j.tice.2022.101798

Article  CAS  PubMed  Google Scholar 

Yaman ME, Ergül G, Güvenç Y, Öztürk Y, Erbay FK, Tolunay T, Şentürk S, Kırçıl C et al (2018) Evaluation of topical Dexmedetomidine administration in postlaminectomy epidural fibrosis rat model. Int J Surg 53:80–85. https://doi.org/10.1016/j.ijsu.2018.03.032

Yang F, Duan Y, Li Y, Zhu D, Wang Z, Luo Z, Zhang Y, Zhang G et al (2024) S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study. Mol Med 30(1):87. https://doi.org/10.1186/s10020-024-00853-4

Yang F, Liu W, Huang Y, Yang S, Shao Z, Cai X, Xiong L (2022) Regulated cell death: Implications for intervertebral disc degeneration and therapy. J Orthop Transl 37:163–172. https://doi.org/10.1016/j.jot.2022.10.009

Yang S, Zhang F, Ma J, Ding W (2020) Intervertebral disc agieing and degeneration: the antiapoptotic effect of oestrogen. Ageing Res Rev 57:100978. https://doi.org/10.1016/j.arr.2019.100978

Article  CAS  PubMed  Google Scholar 

Yang X, Sun Y, Li X, Zhang W (2022b) Rac1 regulates nucleus pulposus cell degeneration by activating the Wnt/β-catenin signaling pathway and promotes the progression of intervertebral disc degeneration. Am J Physiol Cell Physiol 322(3):C496–C507. https://doi.org/10.1152/ajpcell.00355.2021

Article  CAS  PubMed  Google Scholar 

Zhao H, Ming T, Tang S, Ren S, Yang H, Liu M, Tao Q, Xu H (2022) Wnt signaling in colorectal cancer: pathogenic role and therapeutic target. Mol Cancer 21(1):144. https://doi.org/10.1186/s12943-022-01616-7

Zhong Y, Wang J, Liang Z, Han T, Lu H, Hou Z (2024) Bibliometric and visualization analysis of research hotspots and frontiers in endoscopic lumbar laminectomy. J Pain Res 17:2165–2190. https://doi.org/10.2147/jpr.S450586

Article  PubMed  PubMed Central  Google Scholar 

Zhou R, Long H, Zhang B, Lao Z, Zheng Q, Wang T, Zhang Y, Wu Q et al (2019) Salvianolic acid B, an antioxidant derived from Salvia miltiorrhiza, protects mice against γ-radiation-induced damage through Nrf2/Bach1. Mol Med Rep 19(2):1309–1317. https://doi.org/10.3892/mmr.2018.9718

Zhu D, Chen S, Sheng P, Wang Z, Li Y, Kang X (2024) POSTN promotes nucleus pulposus cell senescence and extracellular matrix metabolism via activing Wnt/β-catenin and NF-κB signaling pathway in intervertebral disc degeneration. Cellular SignalingSignalling 121:111277. https://doi.org/10.1016/j.cellsig.2024.111277

Article  CAS  Google Scholar 

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