VEGFA is essential for the potentiation of ATRA on BMP9-induced osteogenesis of preadipocytes and osteoporotic fracture healing

Akiyama H, Tanaka T, Maeno T, Kanai H, Kimura Y, Kishi S, Kurabayashi M (2002) Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 cells. Invest Ophth Vis Sci 43(5):1367–74

Google Scholar 

Akiyama I, Yoshino O, Osuga Y, Shi J, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S, Kozuma S (2014) Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. Reprod Sci 21(4):477–482

Article  PubMed  Google Scholar 

Aryal R, Chen X, Fang C, Hu Y (2014) Bone morphogenetic protein-2 and vascular endothelial growth factor in bone tissue regeneration: new insight and perspectives. Orthop Surg 6(3):171–178

Article  PubMed  PubMed Central  Google Scholar 

Berendsen AD, Olsen BR (2015) Regulation of adipogenesis and osteogenesis in mesenchymal stem cells by vascular endothelial growth factor A. J Intern Med 277(6):674–680

Article  CAS  PubMed  Google Scholar 

Cheung WH, Miclau T, Chow SK, Yang FF, Alt V (2016) Fracture healing in osteoporotic bone. Injury 47(Suppl 2):S21–S26

Article  PubMed  Google Scholar 

Chien CY, Yuan TA, Cho CH, Chang FP, Mao WY, Wu RR, Lee HS, Shen CN (2016) All-trans retinoic acid ameliorates glycemic control in diabetic mice via modulating pancreatic islet production of vascular endothelial growth factor-A. Biochem Biophys Res Commun 477(4):874–880

Article  CAS  PubMed  Google Scholar 

Cui F, Wang X, Liu X, Dighe AS, Balian G, Cui Q (2010) VEGF and BMP-6 enhance bone formation mediated by cloned mouse osteoprogenitor cells. Growth Factors 28(5):306–317

Article  CAS  PubMed  Google Scholar 

Deckers MM, van Bezooijen RL, van der Horst G, Hoogendam J, van Der Bent C, Papapoulos SE, Löwik CW (2002) Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A. Endocrinology 143(4):1545–1553

Article  CAS  PubMed  Google Scholar 

Dou DD, Zhou G, Liu HW, Zhang J, Liu ML, Xiao XF, Fei JJ, Guan XL, Fan YB (2019) Sequential releasing of VEGF and BMP-2 in hydroxyapatite collagen scaffolds for bone tissue engineering: design and characterization. Int J Biol Macromol 123:622–628

Article  CAS  PubMed  Google Scholar 

Gesta S, Tseng Y, Kahn CR (2007) Developmental origin of fat: tracking obesity to its source. Cell 131(2):242–256

Article  CAS  PubMed  Google Scholar 

Hankenson KD, Gagne K, Shaughnessy M (2015) Extracellular signaling molecules to promote fracture healing and bone regeneration. Adv Drug Deliv Rev 94:3–12

Article  CAS  PubMed  Google Scholar 

Harris K, Zagar CA, Lawrence KV (2023) Osteoporosis: common questions and answers. Am Fam Physician 107(3):238–246

PubMed  Google Scholar 

Ji X, Chen D, Xu C, Harris SE, Mundy GR, Yoneda T (2000) Patterns of gene expression associated with BMP-2-induced osteoblast and adipocyte differentiation of mesenchymal progenitor cell 3T3-F442A. J Bone Miner Metab 18(3):132–139

Article  CAS  PubMed  Google Scholar 

Justesen J, Pedersen SB, Stenderup K, Kassem M (2004) Subcutaneous adipocytes can differentiate into bone-forming cells in vitro and in vivo. Tissue Eng 10(3–4):381–391

Article  CAS  PubMed  Google Scholar 

Kanczler JM, Ginty PJ, White L, Clarke NM, Howdle SM, Shakesheff KM, Oreffo RO (2010) The effect of the delivery of vascular endothelial growth factor and bone morphogenic protein-2 to osteoprogenitor cell populations on bone formation. Biomaterials 31(6):1242–1250

Article  CAS  PubMed  Google Scholar 

Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC (2004) Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 11(17):1312–1320

Article  CAS  PubMed  Google Scholar 

Kini AR, Peterson LA, Tallman MS, Lingen MW (2001) Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid. Blood 97(12):3919–3924

Article  CAS  PubMed  Google Scholar 

Kwon TG, Zhao X, Yang Q, Li Y, Ge C, Zhao G, Franceschi RT (2011) Physical and functional interactions between Runx2 and HIF-1α induce vascular endothelial growth factor gene expression. J Cell Biochem 112(12):3582–3593

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li B, Wang H, Qiu G, Su X, Wu Z (2016) Synergistic effects of vascular endothelial growth factor on bone morphogenetic proteins induced bone formation in vivo: influencing factors and future research directions. Biomed Res Int 2016:2869572

Article  PubMed  PubMed Central  Google Scholar 

Li J, Chen K, Li X, Zhang X, Zhang L, Yang Q, Xia Y, Xie C, Wang X, Tong J, Shen Y (2023) Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy. Cell Death Discov 9(1):418

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang C, Guo S, Yang L (2014) Effects of all-trans retinoic acid on VEGF and HIF-1α expression in glioma cells under normoxia and hypoxia and its anti-angiogenic effect in an intracerebral glioma model. Mol Med Rep 10(5):2713–2719

Article  PubMed  Google Scholar 

Liang C, Yang L, Guo S, Li R (2022) Downregulation of astrocyte elevated gene-1 expression combined with all-trans retinoic acid inhibits development of vasculogenic mimicry and angiogenesis in glioma. Curr Med Sci 42(2):397–406

Article  CAS  PubMed  Google Scholar 

Liang K, Du Y, Chen L, Wang L, Li R, Yan Z, Liu Y (2020) Contrary roles of Wnt/β-Catenin signaling in BMP9-induced osteogenic and adipogenic differentiation of 3T3-L1 preadipocytes. Cell Biochem Biophys 78(3):347–356

Article  CAS  PubMed  Google Scholar 

Liu Y, Liu Y, Zhang R, Wang X, Huang F, Yan Z, Nie M, Huang J, Wang Y, Wang Y, Chen L, Yin L, He B, Deng Z (2014) All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways. Int J Biochem Cell Biol 47:47–56

Article  CAS  PubMed  Google Scholar 

Liu Z, Li Y, Yang J, Huang J, Luo C, Zhang J, Yan W, Ao Y (2021) Bone morphogenetic protein 9 enhances osteogenic and angiogenic responses of human amniotic mesenchymal stem cells cocultured with umbilical vein endothelial cells through the PI3K/AKT/m-TOR signaling pathway. Aging Albany NY 13(22):24829–24849

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo J, Deng ZL, Luo X, Tang N, Song WX, Chen J, Sharff KA, Luu HH, Haydon RC, Kinzler KW, Vogelstein B, He TC (2007) A protocol for rapid generation of recombinant adenoviruses using the AdEasy system. Nat Protoc 2(5):1236–1247

Article  CAS  PubMed  Google Scholar 

Maeno T, Tanaka T, Sando Y, Suga T, Maeno Y, Nakagawa J, Hosono T, Sato M, Akiyama H, Kishi S, Nagai R, Kurabayashi M (2002) Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through Sp1 and Sp3 sites in human bronchioloalveolar carcinoma cells. Am J Respir Cell Mol Biol 26(2):246–253

Article  CAS  PubMed  Google Scholar 

Manning BD, Toker A (2017) AKT/PKB signaling: navigating the network. Cell 169(3):381–405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murakami J, Ishii M, Suehiro F, Ishihata K, Nakamura N, Nishimura M (2017) Vascular endothelial growth factor-C induces osteogenic differentiation of human mesenchymal stem cells through the ERK and RUNX2 pathway. Biochem Biophys Res Commun 484(3):710–718

Article  CAS  PubMed  Google Scholar 

Park SR, Oreffo RO, Triffitt JT (1999) Interconversion potential of cloned human marrow adipocytes in vitro. Bone 24(6):549–554

Article  CAS  PubMed 

Comments (0)

No login
gif