Intraglandular Botulinum Toxin Injection for Sialorrhea in the Neurologic Intensive Care Unit

Hockstein NG, Samadi DS, Gendron K, Handler SD. Sialorrhea: A Management Challenge. Am Fam Physician. 2004;69(11):2628–35.

PubMed  Google Scholar 

Marik PE. Aspiration Pneumonitis and Aspiration Pneumonia. N Engl J Med. 2001;344(9):665–71.

Article  CAS  PubMed  Google Scholar 

Hughes A, Lambert EM. Drooling and Aspiration of Saliva. Otolaryngol Clin North Am. 2022;55(6):1181–94.

Article  PubMed  Google Scholar 

Cook D, De Jonghe B, Brochard L, Brun-Buisson C. Influence of Airway Management on Ventilator-Associated PneumoniaEvidence From Randomized Trials. JAMA. 1998;279(10):781–7.

Article  CAS  PubMed  Google Scholar 

Mestre T, Freitas E, Basndwah A, Lopez M, Shinawi H, Oliveira L et al. GLYCOPAR: A randomized, placebo-controlled, two-arm parallel-group superiority phase II study of glycopyrrolate for moderate-to-severe sialorrhea in Parkinson’s disease (2697). Neurology [Internet]. 2020 Apr 14 [cited 2023 Sep 1];94(15 Supplement). Available from: https://n.neurology.org/content/94/15_Supplement/2697

Mier RJ, Bachrach SJ, Lakin RC, Barker T, Childs J, Moran M. Treatment of Sialorrhea With Glycopyrrolate: A Double-blind, Dose-Ranging Study. Arch Pediatr Adolesc Med. 2000;154(12):1214–8.

Article  CAS  PubMed  Google Scholar 

Bachrach SJ, Walter RS, Trzcinski K. Use of Glycopyrrolate and Other Anticholinergic Medications for Sialorrhea in Children with Cerebral Palsy. Clin Pediatr (Phila). 1998;37(8):485–90.

Article  CAS  PubMed  Google Scholar 

Chan KH, Liang C, Wilson P, Higgins D, Allen GC. Long-term safety and efficacy data on botulinum toxin type A: an injection for sialorrhea. JAMA Otolaryngol– Head Neck Surg. 2013;139(2):134–8.

Article  PubMed  Google Scholar 

Ondo WG, Hunter C, Moore W. A double-blind placebo-controlled trial of botulinum toxin B for sialorrhea in Parkinson’s disease. Neurology. 2004;62(1):37–40.

Article  CAS  PubMed  Google Scholar 

Verma A, Steele J. Botulinum toxin improves sialorrhea and quality of living in bulbar amyotrophic lateral sclerosis. Muscle Nerve. 2006;34(2):235–7.

Article  CAS  PubMed  Google Scholar 

Isaacson SH, Ondo W, Jackson CE, Trosch RM, Molho E, Pagan F, et al. Safety and Efficacy of RimabotulinumtoxinB for Treatment of Sialorrhea in Adults: A Randomized Clinical Trial. JAMA Neurol. 2020;77(4):461–9.

Article  PubMed  PubMed Central  Google Scholar 

Jongerius PH, Hoogen FJA, van van den, Limbeek J, Gabreëls FJ, van Hulst K, Rotteveel JJ. Effect of Botulinum Toxin in the Treatment of Drooling: A Controlled Clinical Trial. Pediatrics. 2004;114(3):620–7.

Article  PubMed  Google Scholar 

Vashishta R, Nguyen SA, White DR, Gillespie MB. Botulinum Toxin for the Treatment of Sialorrhea: A Meta-analysis. Otolaryngol Neck Surg. 2013;148(2):191–6.

Article  Google Scholar 

Kang Y, Chun MH, Lee SJ. Evaluation of salivary aspiration in brain-injured patients with tracheostomy. Ann Rehabil Med. 2013;37(1):96–102.

Article  PubMed  PubMed Central  Google Scholar 

Jost WH, Friedman A, Michel O, Oehlwein C, Slawek J, Bogucki A, et al. SIAXI: Placebo-controlled, randomized, double-blind study of incobotulinumtoxinA for sialorrhea. Neurology. 2019;92(17):e1982–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lagalla G, Millevolte M, Capecci M, Provinciali L, Ceravolo MG. Botulinum toxin type A for drooling in Parkinson’s disease: a double-blind, randomized, placebo-controlled study. Mov Disord Off J Mov Disord Soc. 2006;21(5):704–7.

Article  Google Scholar 

Mancini F, Zangaglia R, Cristina S, Sommaruga MG, Martignoni E, Nappi G, et al. Double-blind, placebo-controlled study to evaluate the efficacy and safety of botulinum toxin type A in the treatment of drooling in parkinsonism. Mov Disord Off J Mov Disord Soc. 2003;18(6):685–8.

Article  Google Scholar 

Dogu O, Apaydin D, Sevim S, Talas DU, Aral M. Ultrasound-guided versus blind intraparotid injections of botulinum toxin-A for the treatment of sialorrhoea in patients with Parkinson’s disease. Clin Neurol Neurosurg. 2004;106(2):93–6.

Article  PubMed  Google Scholar 

Lipp A, Trottenberg T, Schink T, Kupsch A, Arnold G. A randomized trial of botulinum toxin A for treatment of drooling. Neurology. 2003;61(9):1279–81.

Article  CAS  PubMed  Google Scholar 

Tan EK. Botulinum toxin treatment of sialorrhea: comparing different therapeutic preparations. Eur J Neurol. 2006;13(s1):60–4.

Article  PubMed  Google Scholar 

Comella C, Hast M, Hanschmann A. Pooled Safety Analysis of IncobotulinumtoxinA in the Treatment of Neurological Disorders in Adults (P12-11.007). Neurology [Internet]. 2023 Apr 25 [cited 2023 Sep 3];100(17 Supplement 2). Available from: https://n.neurology.org/content/100/17_Supplement_2/1578

Guidubaldi A, Fasano A, Ialongo T, Piano C, Pompili M, Mascianà R, et al. Botulinum toxin A versus B in sialorrhea: a prospective, randomized, double-blind, crossover pilot study in patients with amyotrophic lateral sclerosis or Parkinson’s disease. Mov Disord Off J Mov Disord Soc. 2011;26(2):313–9.

Article  Google Scholar 

Evatt ML, Chaudhuri KR, Chou KL, Cubo E, Hinson V, Kompoliti K, et al. Dysautonomia Rating Scales in Parkinson’s Disease: Sialorrhea, Dysphagia, and Constipation—Critique and Recommendations by Movement Disorders Task Force on Rating Scales for Parkinson’s Disease. Mov Disord Off J Mov Disord Soc. 2009;24(5):635–46.

Article  Google Scholar 

Rodrigues B, Nóbrega AC, Sampaio M, Argolo N, Melo A. Silent saliva aspiration in Parkinson’s disease. Mov Disord. 2011;26(1):138–41.

Article  PubMed  Google Scholar 

Armstrong JR, Mosher BD. Aspiration pneumonia after stroke: intervention and prevention. Neurohospitalist. 2011;1(2):85–93.

Article  PubMed  PubMed Central  Google Scholar 

Heuschmann PU, Kolominsky-Rabas PL, Misselwitz B, Hermanek P, Leffmann C, Janzen RWC, et al. Predictors of In-Hospital Mortality and Attributable Risks of Death After Ischemic Stroke: The German Stroke Registers Study Group. Arch Intern Med. 2004;164(16):1761–8.

Article  PubMed  Google Scholar 

Faria J, Harb J, Hilton A, Yacobucci D, Pizzuto M. Salivary botulinum toxin injection may reduce aspiration pneumonia in neurologically impaired children. Int J Pediatr Otorhinolaryngol. 2015;79(12):2124–8.

Article  PubMed  Google Scholar 

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